Investigational Drugs

Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.

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     PPAR
29 records.
Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D009 ALS-L1023 Chemical drug -- PPARA / Angiogenesis Anti-inflammatory Under clinical trials Details
D033 Bezafibrate Chemical drug DB01393 PPARA agonist; PPARD agonist; PPARG agonist; NR1I2 partial agonist Improve insulin resistance; Anti-inflammatory Under clinical trials Details
D092 Curcumin Chemical drug DB11672 PPARG; COX inhibitor Anticancer agent; NSAID Under clinical trials Details
D105 DHA Chemical drug DB03756 PPARA ligand; PPARG ligand Anti-inflammatory Under clinical trials Details
D119 Elafibranor Chemical drug DB05187 PPARA; PPARD; PPARG Anti-inflammatory Failed in clinical trials Details
D125 Epanova Chemical drug DB11133 PPARG ligand; PPARA activator Enhance lipid metabolism Under clinical trials Details
D133 Fenofibrate Chemical drug DB01039 PPARA agonist; NR1I2 partial agonist Anti-inflammatory Under clinical trials Details
D137 Fish oil Biological drug DB13961 -- -- Under clinical trials Details
D149 Gemcabene Chemical drug DB05123 ACC inhibitor; apo C-III inhibitor; CRP inhibitor; CCR2 receptor antagonist; CCR5 receptor antagonist; lipoprotein A inhibitor; PPAR agonist; sulfatase inhibitor Enhance lipid metabolism; Anti-fibrosis Failed in clinical trials Details
D200 Lanifibranor Chemical drug DB14801 PPARD agonist; PPARA agonist; PPARG agonist Dermatological drug Advanced in clinical trials Details
D208 Lobeglitazone Chemical drug DB09198 PPARG activator Improve insulin resistance Under clinical trials Details
D237 Nesinaact Chemical drug -- CD26 antigen inhibitor; PPARG agonist Improve insulin resistance Under clinical trials Details
D253 Oleoylethanolamide Chemical drug DB16495 -- -- Under clinical trials Details
D258 Omega 3 PUFA Chemical drug DB11133 PPARG ligand; PPARA activator Hypolipidemic drug Under clinical trials Details
D265 Pemafibrate Chemical drug DB15212 PPARA modulator Anti-inflammatory Under clinical trials Details
D267 Perindopril Chemical drug DB00790 ACE inhibitor Antihypertensive drug Under clinical trials Details
D275 Pioglitazone Chemical drug DB01132 PPARG agonist Improve insulin resistance Advanced in clinical trials Details
D311 Rosiglitazone Chemical drug DB00412 PPARG agonist; PPARA; PPARD Improve insulin resistance Failed in clinical trials Details
D321 Saroglitazar Chemical drug DB13115 PPARA agonist; PPARG agonist Antidiabetic drug Approved in India Details
D360 Telmisartan Chemical drug DB00966 PPARG partial agonist Improve insulin resistance Under clinical trials Details
D378 Troglitazone Chemical drug DB00197 PPARG agonist; PPARD; PPARA Improve insulin resistance Under investigation Details
D381 Ursodeoxycholic acid Chemical drug DB01586 AKR1C2 inducer Anti-inflammatory Under clinical trials Details
D382 Vigabatrin Chemical drug DB01080 GABBR1 agonist; ABAT inhibitor Antiepileptic drug Under clinical trials Details
D406 Gemfibrozil Chemical drug DB01241 PPARA agonist; SLCO1B1 inhibitor; SLC22A8 inhibitor; SLCO2B1 inhibitor; SLCO1B3 inhibitor Hypolipidemic drug Under investigation Details
D451 Selonsertib + Firsocostat, Cilofexor, Fenofibrate or Vascepa Combinatory -- ASK1 inhibitor & ACC inhibitor & FXR agonist & PPAR-α activator & icosapent ethyl -- Under clinical trials Details
D454 Vitamin E + Saraglitazar + Lifestyle Changes Combinatory -- PPARα/γ agonist Antioxidant Under clinical trials Details
D523 Capparis Spinosa Fruit pickle Herbal medicine -- -- -- Under clinical trials Details
D527 EPA/DHA Supplement DB11133 -- -- Under clinical trials Details
D571 GW7647 Miscellany -- PPARα agonist Anti-diabetic drugs Under investigation Details