Therapeutic Target Details
| Target ID: | T16 |
| Target Name: | Niemann-Pick C1-like protein 1 |
| Synonyms: | Niemann-Pick C1-like protein 1 precursor; NPC1L1 |
| GENE: | NPC1L1 |
| Action: | inhibitor |
| Class: | Membrane other |
| UniProtKB ID: | Q9UHC9 |
| Entry Name: | NPCL1_HUMAN |
| Related Drugs: | Ezetimibe |
| Mechanism: | Duodenal NPC1L1 expression was decreased in NAFLD and was negatively correlated with LXR expression in PMN cells. The livers of Ad‑L1 mice represent a more human‑like state for the study of hepatic autophagy. Hepatic expression of human NPC1L1 resulted in an inhibition of autophagy; it may contribute to alcoholic fatty liver disease in humans. |
| Reference (PMIDs): | 29466845; 31432115 |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B001101 | CHEMBL112570 | Small molecule | CHOLESTEROL | 386.66 | C27H46O | NEUTRAL | Details |
| B001129 | CHEMBL1138 | Small molecule | EZETIMIBE | 409.43 | C24H21F2NO3 | NEUTRAL | Details |
| B002250 | CHEMBL1243244 | Small molecule | -- | 402.66 | C27H46O2 | NEUTRAL | Details |
| B002595 | CHEMBL1277915 | Small molecule | -- | 418.66 | C27H46O3 | NEUTRAL | Details |
| B002599 | CHEMBL1278089 | Small molecule | CHOLESTAN-3beta,5alpha,6beta-TRIOL | 420.68 | C27H48O3 | NEUTRAL | Details |
| B002600 | CHEMBL1278177 | Small molecule | 7-OXOCHOLESTEROL | 400.65 | C27H44O2 | NEUTRAL | Details |
| B085493 | CHEMBL1629728 | Small molecule | -- | 609.79 | C32H43N5O5S | NEUTRAL | Details |
| B085494 | CHEMBL1629869 | Small molecule | -- | 546.71 | C32H42N4O4 | NEUTRAL | Details |
| B085495 | CHEMBL1629878 | Small molecule | -- | 520.63 | C29H36N4O5 | NEUTRAL | Details |
| B085496 | CHEMBL1629879 | Small molecule | -- | 534.66 | C30H38N4O5 | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|