Therapeutic Target Details
| Target ID: | T19 |
| Target Name: | Acetyl-CoA carboxylase 2 |
| Synonyms: | ACC-beta; ACC2; ACCB; ACACB |
| GENE: | ACACB |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | O00763 |
| Entry Name: | ACACB_HUMAN |
| Related Drugs: | Firsocostat |
| Mechanism: | Acetyl-CoA carboxylases (ACCs) catalyse the committed step in DNL through the conversion of acetyl-CoA to malonyl-CoA. Furthermore, the product of this reaction, malonyl-CoA, is a signalling molecule that suppresses fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1. Thus, ACC inhibition could reduce hepatic lipid accumulation by suppressing DNL and stimulating fatty acid oxidation. ACC inhibitors improve hepatic steatosis and insulin sensitivity but increase plasma concentrations of triglyceride in mice, rats and humans. |
| Reference (PMIDs): | 26976583 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0037 | DB00121 | approved; investigational; nutraceutical | small molecule | Biotin | Target associated | Details |
| R0060 | DB00173 | approved; nutraceutical | small molecule | Adenine | Target associated | Details |
| R0572 | DB02859 | experimental | small molecule | Soraphen A | Target associated | Details |
| R0591 | DB03781 | experimental | small molecule | 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid | Target associated | Details |
| R1132 | DB07870 | experimental | small molecule | Haloxyfop-P | Target associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000230 | CHEMBL1076223 | Small molecule | -- | 607.8 | C37H45N5O3 | NEUTRAL | Details |
| B000700 | CHEMBL1088860 | Small molecule | -- | 405.45 | C23H23N3O4 | NEUTRAL | Details |
| B000703 | CHEMBL1088893 | Small molecule | -- | 455.52 | C26H25N5O3 | NEUTRAL | Details |
| B000704 | CHEMBL1088894 | Small molecule | -- | 455.52 | C26H25N5O3 | NEUTRAL | Details |
| B000707 | CHEMBL1088921 | Small molecule | -- | 468.51 | C27H24N4O4 | NEUTRAL | Details |
| B000715 | CHEMBL1089138 | Small molecule | -- | 389.46 | C23H23N3O3 | NEUTRAL | Details |
| B000716 | CHEMBL1089139 | Small molecule | -- | 391.43 | C22H21N3O4 | NEUTRAL | Details |
| B000721 | CHEMBL1089180 | Small molecule | -- | 391.43 | C21H21N5O3 | NEUTRAL | Details |
| B000722 | CHEMBL1089181 | Small molecule | -- | 434.5 | C24H26N4O4 | NEUTRAL | Details |
| B000723 | CHEMBL1089206 | Small molecule | -- | 392.42 | C21H20N4O4 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | Details |
| A12201 | 30564000 | J Clin Exp Hepatol | Genetic and Epigenetic Culprits in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | Details |
| A26753 | 19832698 | Clin Sci (Lond) | Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. | Details |