Repositioning Candidate Details
| Candidate ID: | R0060 |
| Source ID: | DB00173 |
| Source Type: | approved; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Adenine |
| Synonyms: | 6-Aminopurine; Adenin; Adenine; Vitamin B4 |
| Molecular Formula: | C5H5N5 |
| SMILES: | NC1=C2NC=NC2=NC=N1 |
| Structure: |
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| DrugBank Description: | A purine base and a fundamental unit of adenine nucleotides. |
| CAS Number: | 73-24-5 |
| Molecular Weight: | 135.1267 |
| DrugBank Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance |
| DrugBank Pharmacology: | Adenine (sometimes known as vitamin B4) combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP . These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids. A modified form of adenosine monophosphate (cyclic AMP) is an imporant secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes. Adenosine (adenine with a ribose group) causes transient heart block in the AV node of the heart. In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. Certain SVTs can be successfully terminated with adenosine. |
| DrugBank MoA: | Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), which drives many cellular metabolic processes by transferring chemical energy between reactions. |
| Targets: | Adenine phosphoribosyltransferase; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Acetyl-CoA carboxylase 2; Low molecular weight phosphotyrosine protein phosphatase; Peroxisomal trans-2-enoyl-CoA reductase; A/G-specific adenine glycosylase; Nucleoside deoxyribosyltransferase-I; SRSF protein kinase 2; Holliday junction ATP-dependent DNA helicase RuvB; DNA; S-methyl-5'-thioadenosine phosphorylase; Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |