Therapeutic Target Details
| Target ID: | T39 |
| Target Name: | Glutathione S-transferase Mu 2 |
| Synonyms: | GSTM2; GST4 |
| GENE: | GSTM2 |
| Action: | agonist |
| Class: | Enzyme |
| UniProtKB ID: | P28161 |
| Entry Name: | GSTM2_HUMAN |
| Related Drugs: | None |
| Mechanism: | These data demonstrated that hepatocyte GSTM2 is an endogenous suppressor that protects against NASH progression by blocking ASK1 N-terminal dimerization and phosphorylation. Activating GSTM2 holds promise as a therapeutic strategy for NASH. |
| Reference (PMIDs): | 34656650 |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0563 | DB02458 | experimental | small molecule | S-(2,4-dinitrophenyl)glutathione | Target associated | Details |
| R0580 | DB03310 | approved; experimental; investigational | small molecule | Glutathione disulfide | Target associated | Details |
| R0613 | DB04701 | experimental | small molecule | S-Methyl glutathione | Target associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B002150 | CHEMBL1234570 | Small molecule | -- | 297.34 | C12H15N3O4S | NEUTRAL | Details |
| B086074 | CHEMBL167468 | Small molecule | -- | 192.0 | C6H3Cl2NO2 | NEUTRAL | Details |
| B095290 | CHEMBL1743209 | Small molecule | -- | 352.47 | C20H32O5 | ACID | Details |
| B095291 | CHEMBL1743210 | Small molecule | AMINOCHROME | 149.15 | C8H7NO2 | NEUTRAL | Details |
| B095292 | CHEMBL1743218 | Small molecule | -- | 195.17 | C9H9NO4 | ZWITTERION | Details |
| B116667 | CHEMBL2430532 | Small molecule | -- | 287.3 | C13H9N3O3S | NEUTRAL | Details |
| B116668 | CHEMBL2430537 | Small molecule | -- | 273.27 | C12H7N3O3S | NEUTRAL | Details |
| B118147 | CHEMBL301229 | Small molecule | -- | 425.51 | C19H27N3O6S | ZWITTERION | Details |
| B125230 | CHEMBL3335620 | Small molecule | -- | 382.32 | C11H13F3N6O4S | BASE | Details |
| B125398 | CHEMBL3352898 | Small molecule | -- | 331.31 | C14H9N3O5S | ACID | Details |