| Outcome Measures: |
Changes in QOL score (The CLDQ-NASH Instrument, Fatigue impact scale ) after interventions for 48 weeks1) Changes in QOL score (The CLDQ-NASH Instrument, Fatigue impact scale ) after 12,24,36,48 week of intervention<br>2) Changes in the parameters described below after 12,24,36,48 week of intervention<br>: body weight, grip strength, SMI, Kihon Check List for Frailty, blood test (liver function, insulin, sugar metabolism, blood count, renal function, electrolyte)<br>3) Changes in the parameters described below after 48 week of intervention.<br>: Computed Tomography (Skeletal muscle mass, skeletal muscle mass (lean fat), intramuscular fat mass, body fat mass)<br>4) Changes in the parameters described below after 24,48 week of intervention<br>: blood test (fibrosis, inflammation), imaging analysis, ultrasonography<br>5) Changes between the end of the study drug administration and 3 weeks after the study drug administration<br>: body weight, grip strength, SMI, QOL score (The CLDQ-NASH Instrument, Fatigue impact scale ), Kihon Check List for Frailty, blood test (liver function, insulin, sugar metabolism, blood count, renal function, electrolyte)<br>6) Active group: Correlation analysis between the changes of QOL score and other parameters at baseline or changes in those<br>7) Active group: Comparison between the subjects with improvement in QOL and ones without improvement in QOL.
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