| Trial ID: | L0490 |
| Source ID: | IRCT20090609002017N32
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| Associated Drug: |
Oleoylethanolamide
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| Title: |
Assessment of oleoylethanolamide supplementation on the expression of SIRT1, AMPK, PGC-1a, PPAR-?, CEBP-a, CEBP- ??, IL-6, and IL-10 genes, serum IL-6, IL-10, and NRG-4 levels, and body composition in obese patients with non-alcoholic fatty liver diseas
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| Acronym: |
--
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| Status: |
Not Recruiting
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| Study Results: |
No Results Available
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| Results: |
--
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| Conditions: |
Non-alcoholic fatty liver disease. <br>Fatty (change of) liver, not elsewhere classified;K76.0
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| Interventions: |
Intervention 1: Intervention group: daily 2 capsules including 125 mg oleoylethanolamide. Intervention 2: Control group: daily 2 capsules including 125 mg placebo.
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| Outcome Measures: |
Gene expression of IL-6. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of IL-10. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time- PCR.;Serum levels of IL-6. Timepoint: before intervention, and 3 months after intervention. Method of measurement: By laboratory ELISA kits.;Serum levels of IL-10. Timepoint: Before intervention, and 3months after intervention. Method of measurement: By laboratory ELISA kits.;Serum levels of NRG-4. Timepoint: Before intervention, and 3months after intervention. Method of measurement: By laboratory ELISA kits.;Gene expression of SIRT1. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of AMPK. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of PGC-1a. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of PPAR-?. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of CEBP-a. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.;Gene expression of CEBP-??. Timepoint: before intervention, and 3 months after intervention. Method of measurement: Real time-PCR.Body composition. Timepoint: Before intervention, and 3 months after intervention. Method of measurement: Measurement of body composition, including fat mass, fat free mass and total body water determination using bioelectrical impedance analyser (BIA).
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| Sponsor/Collaborators: |
Vice chancellor for research , Tabriz University of Medical Sciences, Nutrition Research Center
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| Gender: |
All
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| Age: |
20 years50 years
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| Phases: |
Not applicable
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| Enrollment: |
60
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| Study Type: |
interventional
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| Study Designs: |
Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Samples are assigned to intervention and control groups using simple random design, Blinding description: In this stu
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| Start Date: |
11/08/2018
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| Completion Date: |
--
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| Results First Posted: |
--
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| Last Update Posted: |
26 May 2021
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| Locations: |
Iran (Islamic Republic of)
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| URL: |
http://en.irct.ir/trial/31612
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