Investigational Drug Details
| Drug ID: | D083 |
| Drug Name: | CLA |
| Synonyms: | Conjugated linoleic acid; 6-O-methyl erythromycin; 6-O-methylerythromycin; 6-O-methylerythromycin A; CLA; Clarithromycin |
| Type: | Chemical drug |
| DrugBank ID: | DB01211 |
| DrugBank Description: | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. |
| PubChem ID: | 5282796 |
| CasNo: | 1839-11-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | C(CC=CC=CCCCCCC)CCCCCC(=O)O |
| Structure: |
|
| InChiKey: | JBYXPOFIGCOSSB-UHFFFAOYSA-N |
| Molecular Weight: | 280.452 |
| DrugBank Targets: | 50S ribosomal protein L10 inhibitor; Potassium voltage-gated channel subfamily H member 2; Solute carrier organic anion transporter family member 1B1; Solute carrier organic anion transporter family member 1B3 |
| DrugBank MoA: | Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. |
| DrugBank Pharmacology: | Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (<i>Staphylococcus aureus, S. pneumoniae, and S. pyogenes</i>) and gram-negative aerobic bacteria (<i>Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis</i>), many anaerobic bacteria, some mycobacteria, and some other organisms including <i>Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma</i>, and <i>Borrelia</i>. Other aerobic bacteria that clarithromycin has activity against include <i>C. pneumoniae and M. pneumoniae</i>. Clarithromycin has an in-vitro activity that is similar or greater than that of erythromycin against erythromycin-susceptible organisms. Clarithromycin is usually bacteriostatic, but may be bactericidal depending on the organism and the drug concentration. |
| DrugBank Indication: | An alternative medication for the treatment of acute otitis media caused by <i>H. influenzae, M. catarrhalis, or S. pneumoniae</i> in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible <i>Streptococcus pyogenes</i>, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by <i>Toxoplasma gondii</i> (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for <i>Mycobacterium avium</i> complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection). |
| Targets: | KCNH2; SLCO1B1; SLCO1B3 |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (IRCT2014020516491N1) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0039 | NCT01277094 | Phase 1 | Completed | No Results Available | April 2011 | November 2, 2016 | Details |
| L0061 | NCT01006889 | Phase 4 | Completed | Has Results | January 2008 | September 28, 2016 | Details |
| L0066 | NCT02649465 | Phase 4 | Completed | No Results Available | November 11, 2015 | July 2, 2021 | Details |
| L0073 | NCT05203367 | Phase 1 | Not yet recruiting | No Results Available | February 25, 2022 | January 24, 2022 | Details |
| L0081 | NCT03068065 | Phase 4 | Completed | No Results Available | May 2014 | March 1, 2017 | Details |
| L0083 | NCT03681457 | Phase 1 | Completed | No Results Available | September 24, 2018 | December 14, 2020 | Details |
| L0111 | NCT02826525 | Phase 1 | Completed | No Results Available | July 18, 2016 | April 1, 2021 | Details |
| L0126 | NCT04859322 | Not applicable | Recruiting | No Results Available | February 8, 2021 | April 30, 2021 | Details |
| L0135 | NCT04857437 | Phase 1 | Completed | No Results Available | May 13, 2021 | November 15, 2021 | Details |
| L0162 | NCT04639414 | Phase 4 | Recruiting | No Results Available | March 26, 2021 | January 20, 2022 | Details |
| L0175 | NCT03205150 | Phase 2 | Completed | Has Results | October 4, 2017 | October 8, 2021 | Details |
| L0196 | NCT04971785 | Phase 2 | Recruiting | No Results Available | August 9, 2021 | March 11, 2022 | Details |
| L0204 | NCT04880031 | Phase 2 | Recruiting | No Results Available | September 30, 2021 | February 18, 2022 | Details |
| L0212 | NCT03053050 | Phase 3 | Terminated | Has Results | February 13, 2017 | June 29, 2020 | Details |
| L0214 | NCT03053063 | Phase 3 | Terminated | Has Results | January 30, 2017 | May 7, 2020 | Details |
| L0228 | NCT02970942 | Phase 2 | Completed | Has Results | November 30, 2016 | November 16, 2021 | Details |
| L0230 | EUCTR2020-005187-63-ES | Phase 2 | Authorised | No Results Available | 01/09/2021 | 7 September 2021 | Details |
| L0232 | NCT04483947 | Phase 1 | Recruiting | No Results Available | 06/07/2020 | 24 January 2022 | Details |
| L0234 | IRCT20171102037178N2 | Phase 3 | Recruiting | No Results Available | 11/03/2018 | 26 March 2018 | Details |
| L0237 | NCT04140123 | Phase 1/Phase 2 | Completed | No Results Available | June 23, 2020 | October 11, 2021 | Details |
| L0262 | NCT02913105 | Phase 2 | Terminated | Has Results | October 24, 2016 | January 5, 2021 | Details |
| L0263 | NCT03976687 | Phase 1 | Completed | No Results Available | June 11, 2019 | September 25, 2020 | Details |
| L0291 | NCT04137055 | Phase 1 | Completed | No Results Available | November 19, 2019 | July 28, 2021 | Details |
| L0294 | NCT04913090 | Phase 1 | Recruiting | No Results Available | May 31, 2021 | June 4, 2021 | Details |
| L0295 | NCT05143905 | Phase 1 | Recruiting | No Results Available | December 6, 2021 | March 15, 2022 | Details |
| L0308 | NCT03392779 | Phase 1 | Completed | No Results Available | January 5, 2018 | August 13, 2019 | Details |
| L0311 | NCT02891408 | Phase 1 | Completed | Has Results | September 23, 2016 | December 17, 2020 | Details |
| L0313 | NCT02654002 | Phase 1 | Completed | Has Results | January 20, 2016 | October 12, 2020 | Details |
| L0337 | NCT04146805 | Phase 1 | Completed | No Results Available | January 10, 2020 | June 4, 2021 | Details |
| L0344 | NCT04142424 | Phase 1 | Completed | No Results Available | October 28, 2019 | November 26, 2021 | Details |
| L0352 | NCT02808312 | Phase 1 | Completed | Has Results | July 13, 2016 | January 7, 2021 | Details |
| L0370 | DRKS00027573 | Not applicable | Not Recruiting | No Results Available | 14/01/2022 | 7 February 2022 | Details |
| L0371 | IRCT20091114002709N58 | Phase 3 | Recruiting | No Results Available | 11/01/2022 | 7 February 2022 | Details |
| L0372 | IRCT20220104053626N1 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 11/01/2022 | 7 February 2022 | Details |
| L0376 | EUCTR2020-004986-38-NL | Phase 3 | Authorised | No Results Available | 30/09/2021 | 13 December 2021 | Details |
| L0377 | EUCTR2020-004986-38-HU | Phase 3 | Authorised | No Results Available | 01/09/2021 | 15 November 2021 | Details |
| L0378 | EUCTR2020-004986-38-DE | Phase 3 | Authorised | No Results Available | 13/08/2021 | 2 March 2022 | Details |
| L0380 | EUCTR2020-004986-38-FR | Phase 3 | Authorised | No Results Available | 09/07/2021 | 10 January 2022 | Details |
| L0381 | IRCT20170628034786N4 | Phase 3 | Not Recruiting | No Results Available | 04/07/2021 | 12 July 2021 | Details |
| L0383 | EUCTR2020-003566-39-IT | Phase 2 | Authorised | No Results Available | 07/06/2021 | 30 August 2021 | Details |
| L0392 | ACTRN12621000255886 | Phase 1 | Not Recruiting | No Results Available | 10/03/2021 | 18 October 2021 | Details |
| L0394 | EUCTR2019-001983-31-ES | Phase 2 | Authorised | No Results Available | 17/02/2021 | 7 June 2021 | Details |
| L0395 | IRCT20180412039283N1 | Phase 3 | Not Recruiting | No Results Available | 16/02/2021 | 22 February 2021 | Details |
| L0396 | EUCTR2020-005187-63-HU | Phase 2 | Authorised | No Results Available | 11/02/2021 | 26 April 2021 | Details |
| L0400 | EUCTR2019-001983-31-PL | Phase 2 | Authorised | No Results Available | 29/12/2020 | 21 July 2021 | Details |
| L0408 | EUCTR2019-003048-63-FR | Phase 2 | Authorised | No Results Available | 18/09/2020 | 23 November 2020 | Details |
| L0409 | IRCT20190701044062N3 | Phase 3 | Recruiting | No Results Available | 16/09/2020 | 6 October 2020 | Details |
| L0413 | EUCTR2019-003048-63-DE | Phase 2 | Authorised | No Results Available | 04/09/2020 | 13 December 2021 | Details |
| L0420 | EUCTR2019-001983-31-GB | Phase 2 | Authorised | No Results Available | 05/08/2020 | 30 November 2020 | Details |
| L0422 | EUCTR2019-001983-31-FR | Phase 2 | Authorised | No Results Available | 04/08/2020 | 10 May 2021 | Details |
| L0426 | EUCTR2019-004775-39-SK | Phase 2 | Authorised | No Results Available | 01/06/2020 | 7 February 2022 | Details |
| L0434 | IRCT20150819023685N2 | Phase 3 | Not Recruiting | No Results Available | 22/02/2020 | 24 March 2020 | Details |
| L0438 | EUCTR2019-003876-38-GB | Phase 2 | Authorised | No Results Available | 04/02/2020 | 13 July 2020 | Details |
| L0439 | EUCTR2019-003876-38-DE | Phase 2 | Not Recruiting | No Results Available | 03/02/2020 | 8 November 2021 | Details |
| L0441 | ChiCTR2000029144 | Not applicable | Not Recruiting | No Results Available | 15/01/2020 | 20 January 2020 | Details |
| L0442 | IRCT20190701044062N2 | Phase 2/Phase 3 | Recruiting | No Results Available | 13/01/2020 | 24 February 2020 | Details |
| L0443 | IRCT20121216011763N42 | Not applicable | Recruiting | No Results Available | 10/01/2020 | 24 February 2020 | Details |
| L0447 | IRCT20140107016123N14 | Not applicable | Recruiting | No Results Available | 04/12/2019 | 17 December 2019 | Details |
| L0449 | IRCT20191124045488N1 | Phase 2 | Recruiting | No Results Available | 29/11/2019 | 17 December 2019 | Details |
| L0452 | EUCTR2019-001897-27-FR | Phase 2 | Authorised | No Results Available | 07/10/2019 | 18 May 2020 | Details |
| L0453 | EUCTR2019-002073-56-FR | Phase 4 | Authorised | No Results Available | 20/09/2019 | 1 February 2020 | Details |
| L0454 | EUCTR2019-002073-56-GB | Phase 3 | Authorised | No Results Available | 17/09/2019 | 11 March 2020 | Details |
| L0457 | IRCT20180802040678N2 | Phase 3 | Recruiting | No Results Available | 13/08/2019 | 7 October 2019 | Details |
| L0458 | IRCT20190602043787N1 | Phase 2/Phase 3 | Recruiting | No Results Available | 09/08/2019 | 7 October 2019 | Details |
| L0459 | ISRCTN12833814 | Not applicable | Not Recruiting | No Results Available | 07/08/2019 | 14 September 2020 | Details |
| L0462 | IRCT20190714044196N1 | Phase 3 | Not Recruiting | No Results Available | 31/07/2019 | 7 October 2019 | Details |
| L0465 | EUCTR2018-004012-22-FR | Phase 3 | Authorised | No Results Available | 03/06/2019 | 10 December 2019 | Details |
| L0476 | EUCTR2018-003443-31-CZ | Phase 2 | Authorised | No Results Available | 05/03/2019 | 2 March 2022 | Details |
| L0480 | IRCT20180908040972N1 | Phase 3 | Recruiting | No Results Available | 19/01/2019 | 29 January 2019 | Details |
| L0482 | IRCT20170628034786N2 | Phase 3 | Recruiting | No Results Available | 16/01/2019 | 29 January 2019 | Details |
| L0486 | IRCT20161205031252N10 | Phase 2/Phase 3 | Recruiting | No Results Available | 22/11/2018 | 14 January 2019 | Details |
| L0488 | IRCT20180824040857N1 | Phase 2 | Not Recruiting | No Results Available | 24/10/2018 | 6 October 2020 | Details |
| L0490 | IRCT20090609002017N32 | Not applicable | Not Recruiting | No Results Available | 11/08/2018 | 26 May 2021 | Details |
| L0492 | IRCT20180412039284N2 | Not applicable | Not Recruiting | No Results Available | 19/07/2018 | 11 September 2018 | Details |
| L0493 | EUCTR2017-004365-27-GB | Phase 2 | Not Recruiting | No Results Available | 04/07/2018 | 16 December 2019 | Details |
| L0496 | EUCTR2017-004365-27-FR | Phase 2 | Not Recruiting | No Results Available | 02/07/2018 | 10 December 2019 | Details |
| L0498 | EUCTR2017-003172-32-GB | Phase 2 | Not Recruiting | No Results Available | 16/05/2018 | 9 November 2020 | Details |
| L0502 | IRCT20170722035222N2 | Not applicable | Recruiting | No Results Available | 18/04/2018 | 21 May 2018 | Details |
| L0506 | IRCT20161023030445N2 | Phase 3 | Recruiting | No Results Available | 26/03/2018 | 30 April 2018 | Details |
| L0508 | IRCT20140307016876N3 | Phase 3 | Recruiting | No Results Available | 25/02/2018 | 26 March 2018 | Details |
| L0512 | IRCT20100123003140N15 | Phase 2/Phase 3 | Recruiting | No Results Available | 14/01/2018 | 22 February 2018 | Details |
| L0514 | IRCT20160920029889N1 | Phase 3 | Not Recruiting | No Results Available | 09/01/2018 | 22 February 2018 | Details |
| L0520 | IRCT2017103030489N2 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 16/11/2017 | 22 February 2018 | Details |
| L0521 | IRCT2017102537007N1 | Not applicable | Not Recruiting | No Results Available | 12/11/2017 | 22 February 2018 | Details |
| L0530 | IRCT2014110511763N18 | Not applicable | Not Recruiting | No Results Available | 18/01/2015 | 22 February 2018 | Details |
| L0532 | EUCTR2009-015927-94-GB | Phase 4 | Not Recruiting | Has Results | 17/03/2010 | 25 November 2019 | Details |
| L0536 | IRCT20200304046692N1 | Not applicable | Not Recruiting | No Results Available | 11/03/2020 | 24 March 2020 | Details |
| L0537 | CTRI/2020/03/023814 | Not applicable | Not Recruiting | No Results Available | 06/03/2020 | 24 November 2021 | Details |
| L0539 | CTRI/2020/02/023426 | Not applicable | Not Recruiting | No Results Available | 18/02/2020 | 24 November 2021 | Details |
| L0540 | IRCT2017053034222N1 | Phase 3 | Recruiting | No Results Available | 28/06/2017 | 26 March 2018 | Details |
| L0541 | IRCT2017060212789N14 | Phase 3 | Not Recruiting | No Results Available | 12/06/2017 | 22 February 2018 | Details |
| L0543 | IRCT2016061228411N1 | Phase 2 | Not Recruiting | No Results Available | 31/05/2017 | 22 February 2018 | Details |
| L0544 | IRCT2017012031423N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 22/05/2017 | 22 February 2018 | Details |
| L0548 | DRKS00005767 | Phase 3 | Not Recruiting | No Results Available | 10/05/2017 | 7 February 2022 | Details |
| L0549 | IRCT201701162709N39 | Not applicable | Not Recruiting | No Results Available | 06/05/2017 | 22 February 2018 | Details |
| L0551 | IRCT201702209662N12 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 25/04/2017 | 22 February 2018 | Details |
| L0552 | IRCT201701172709N44 | Phase 3 | Not Recruiting | No Results Available | 10/04/2017 | 13 July 2020 | Details |
| L0553 | EUCTR2016-002965-67-NL | Phase 2 | Authorised | No Results Available | 29/03/2017 | 17 July 2017 | Details |
| L0555 | IRCT2017011514333N65 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 09/03/2017 | 22 February 2018 | Details |
| L0556 | EUCTR2016-000499-83-NL | Phase 2 | Not Recruiting | Has Results | 06/03/2017 | 3 November 2020 | Details |
| L0557 | EUCTR2016-004566-26-DE | Phase 3 | Authorised | No Results Available | 22/02/2017 | 9 October 2017 | Details |
| L0558 | IRCT2016102530489N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 06/02/2017 | 22 February 2018 | Details |
| L0561 | EUCTR2016-002833-31-GB | Not applicable | Not Recruiting | Has Results | -- | -- | Details |
| L0562 | IRCT201610269472N11 | Phase 2 | Recruiting | No Results Available | 22/11/2016 | 22 February 2018 | Details |
| L0568 | IRCT201610069014N121 | Phase 2 | Not Recruiting | No Results Available | 08/10/2016 | 22 February 2018 | Details |
| L0569 | EUCTR2016-001979-70-BE | Phase 2 | Not Recruiting | No Results Available | 23/09/2016 | 2 June 2020 | Details |
| L0575 | EUCTR2015-004473-32-DE | Not applicable | Not Recruiting | No Results Available | -- | -- | Details |
| L0576 | IRCT2016060628299N1 | Not applicable | Not Recruiting | No Results Available | 13/07/2016 | 22 February 2018 | Details |
| L0585 | EUCTR2015-005215-33-SK | Phase 2 | Not Recruiting | No Results Available | 10/05/2016 | 11 May 2020 | Details |
| L0587 | EUCTR2015-004336-35-ES | Phase 2 | Not Recruiting | No Results Available | 18/03/2016 | 28 February 2019 | Details |
| L0590 | IRCT2014101811763N17 | Not applicable | Not Recruiting | No Results Available | 04/02/2016 | 22 February 2018 | Details |
| L0592 | EUCTR2015-005385-38-BE | Phase 3 | Not Recruiting | No Results Available | 29/01/2016 | 16 November 2020 | Details |
| L0593 | JPRN-UMIN000020544 | Not selected | Not Recruiting | No Results Available | 13/01/2016 | 21 May 2019 | Details |
| L0596 | IRCT201511143320N12 | Not applicable | Not Recruiting | No Results Available | 24/12/2015 | 22 February 2018 | Details |
| L0599 | IRCT2015010720595N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 16/11/2015 | 22 February 2018 | Details |
| L0610 | IRCT2015042020951N2 | Not applicable | Not Recruiting | No Results Available | 12/05/2015 | 22 February 2018 | Details |
| L0614 | IRCT2015012520781N1 | Not applicable | Not Recruiting | No Results Available | 04/04/2015 | 22 February 2018 | Details |
| L0616 | EUCTR2014-003107-29-DE | Phase 2 | Not Recruiting | No Results Available | 28/01/2015 | 28 February 2019 | Details |
| L0618 | EUCTR2013-004605-38-AT | Phase 2 | Not Recruiting | No Results Available | 02/12/2014 | 14 November 2016 | Details |
| L0622 | IRCT201408312709N29 | Phase 3 | Not Recruiting | No Results Available | 11/10/2014 | 22 February 2018 | Details |
| L0626 | IRCT2014070218321N1 | Not applicable | Not Recruiting | No Results Available | 04/08/2014 | 22 February 2018 | Details |
| L0629 | IRCT2014020816528N1 | Not applicable | Not Recruiting | No Results Available | 03/05/2014 | 22 February 2018 | Details |
| L0639 | IRCT2013071313069N2 | Phase 3 | Not Recruiting | No Results Available | 22/09/2013 | 22 February 2018 | Details |
| L0641 | EUCTR2013-002984-24-AT | Not applicable | Not Recruiting | No Results Available | 31/07/2013 | 16 February 2015 | Details |
| L0643 | IRCT2012122911920N1 | Not applicable | Not Recruiting | No Results Available | 19/05/2013 | 22 February 2018 | Details |
| L0649 | IRCT2012110911220N1 | Not applicable | Not Recruiting | No Results Available | 16/11/2012 | 22 February 2018 | Details |
| L0651 | EUCTR2012-000295-42-BE | Phase 2 | Not Recruiting | No Results Available | 16/08/2012 | 22 August 2016 | Details |
| L0654 | EUCTR2012-000975-18-DE | Not applicable | Not Recruiting | No Results Available | 03/07/2012 | 27 October 2014 | Details |
| L0655 | EUCTR2012-001975-36-IT | Not applicable | Authorised | No Results Available | 14/06/2012 | 7 January 2013 | Details |
| L0657 | IRCT201202233320N7 | Not applicable | Not Recruiting | No Results Available | 04/05/2012 | 22 February 2018 | Details |
| L0658 | EUCTR2011-003010-17-IT | Not applicable | Authorised | No Results Available | 07/03/2012 | 24 April 2012 | Details |
| L0664 | IRCT201105026361N1 | Phase 2 | Not Recruiting | No Results Available | 16/11/2011 | 22 February 2018 | Details |
| L0673 | EUCTR2010-021515-17-GB | Not applicable | Not Recruiting | No Results Available | 08/10/2010 | 5 November 2012 | Details |
| L0674 | EUCTR2009-015166-62-GB | Phase 3 | Not Recruiting | Has Results | 08/10/2010 | 30 June 2019 | Details |
| L0677 | EUCTR2009-016761-29-GB | Phase 2 | Not Recruiting | No Results Available | 16/04/2010 | 10 December 2019 | Details |
| L0679 | EUCTR2008-002325-37-DE | Not applicable | Authorised | No Results Available | 04/08/2009 | 19 March 2012 | Details |
| L0680 | EUCTR2009-012916-41-DE | Not applicable | Not Recruiting | No Results Available | 24/07/2009 | 24 July 2012 | Details |
| L0689 | EUCTR2008-002361-31-FR | Not applicable | Authorised | No Results Available | 27/06/2008 | 28 August 2012 | Details |
| L0693 | EUCTR2007-002114-19-GB | Not applicable | Not Recruiting | No Results Available | 13/12/2007 | 19 March 2012 | Details |
| L0694 | EUCTR2007-002114-19-DE | Not applicable | Not Recruiting | No Results Available | 30/11/2007 | 7 January 2013 | Details |
| L0695 | EUCTR2007-005089-12-FR | Not applicable | Authorised | No Results Available | 04/10/2007 | 19 March 2012 | Details |
| L0696 | EUCTR2007-003012-61-PT | Not applicable | Not Recruiting | No Results Available | 17/08/2007 | 19 March 2012 | Details |
| L0697 | EUCTR2007-003013-14-PT | Not applicable | Not Recruiting | No Results Available | 17/08/2007 | 11 September 2012 | Details |
| L0701 | IRCT20200419047137N1 | Not applicable | Recruiting | No Results Available | 05/05/2020 | 18 May 2020 | Details |
| L0706 | CTRI/2020/02/023250 | Phase 3 | Not Recruiting | No Results Available | 11/02/2020 | 24 November 2021 | Details |
| L0708 | IRCT20191009045043N1 | Phase 2/Phase 3 | Recruiting | No Results Available | 20/01/2020 | 24 February 2020 | Details |
| L0710 | IRCT20150706023083N3 | Phase 3 | Recruiting | No Results Available | 29/12/2019 | 13 January 2020 | Details |
| L0711 | IRCT20120718010333N5 | Phase 3 | Not Recruiting | No Results Available | 25/12/2019 | 26 May 2021 | Details |
| L0713 | IRCT20190103042219N1 | Not applicable | Not Recruiting | No Results Available | 14/12/2019 | 17 December 2019 | Details |
| L0714 | IRCT20150205020965N5 | Phase 3 | Not Recruiting | No Results Available | 13/12/2019 | 17 August 2020 | Details |
| L0715 | IRCT20150205020965N4 | Phase 3 | Not Recruiting | No Results Available | 13/12/2019 | 6 October 2020 | Details |
| L0716 | CTRI/2019/12/022339 | Phase 3/Phase 4 | Not Recruiting | No Results Available | 12/12/2019 | 24 November 2021 | Details |
| L0717 | IRCT20191015045113N1 | Phase 3 | Not Recruiting | No Results Available | 08/12/2019 | 17 December 2019 | Details |
| L0718 | IRCT20121216011763N39 | Not applicable | Not Recruiting | No Results Available | 26/11/2019 | 17 December 2019 | Details |
| L0719 | IRCT20120415009472N20 | Phase 2 | Recruiting | No Results Available | 12/11/2019 | 17 December 2019 | Details |
| L0720 | IRCT20190901044662N1 | Not applicable | Not Recruiting | No Results Available | 07/11/2019 | 17 December 2019 | Details |
| L0724 | IRCT20150802023468N6 | Phase 2 | Not Recruiting | No Results Available | 28/10/2019 | 5 November 2019 | Details |
| L0726 | IRCT20120415009472N19 | Phase 2 | Recruiting | No Results Available | 14/10/2019 | 5 November 2019 | Details |
| L0730 | IRCT20150706023083N2 | Phase 3 | Not Recruiting | No Results Available | 23/09/2019 | 5 November 2019 | Details |
| L0736 | IRCT20181119041701N1 | Phase 3 | Not Recruiting | No Results Available | 05/07/2019 | 26 August 2019 | Details |
| L0743 | IRCT20180903040941N1 | Not applicable | Recruiting | No Results Available | 03/06/2019 | 26 August 2019 | Details |
| L0744 | EUCTR2018-004484-31-ES | Phase 2 | Authorised | No Results Available | 24/05/2019 | 30 June 2019 | Details |
| L0749 | IRCT20170206032417N4 | Not applicable | Recruiting | No Results Available | 28/04/2019 | 21 May 2019 | Details |
| L0754 | CTRI/2019/04/018550 | Not applicable | Not Recruiting | No Results Available | 10/04/2019 | 24 November 2021 | Details |
| L0755 | CTRI/2019/03/018039 | Phase 2/Phase 3 | Recruiting | No Results Available | 12/03/2019 | 24 November 2021 | Details |
| L0756 | IRCT20181023041431N1 | Phase 3 | Recruiting | No Results Available | 09/03/2019 | 25 March 2019 | Details |
| L0758 | CTRI/2018/03/012723 | Not applicable | Recruiting | No Results Available | 21/03/2018 | 24 November 2021 | Details |
| L0768 | IRCT20110530006652N2 | Phase 3 | Not Recruiting | No Results Available | 07/02/2019 | 18 May 2020 | Details |
| L0769 | EUCTR2018-004484-31-GB | Phase 2 | Authorised | No Results Available | 31/01/2019 | 10 December 2019 | Details |
| L0774 | IRCT20150124020765N2 | Phase 3 | Recruiting | No Results Available | 06/01/2019 | 29 January 2019 | Details |
| L0779 | IRCT20180404039187N2 | Phase 3 | Not Recruiting | No Results Available | 23/11/2018 | 14 January 2019 | Details |
| L0780 | IRCT20180404039187N1 | Phase 2/Phase 3 | Recruiting | No Results Available | 22/11/2018 | 14 January 2019 | Details |
| L0791 | NCT03627819 | Not applicable | Not recruiting | No Results Available | 18/07/2018 | 12 December 2020 | Details |
| L0792 | IRCT20170430033730N2 | Not applicable | Not Recruiting | No Results Available | 02/07/2018 | 11 September 2018 | Details |
| L0795 | IRCT20180513039634N1 | Phase 3 | Recruiting | No Results Available | 13/06/2018 | 16 July 2018 | Details |
| L0796 | IRCT20090804002288N13 | Not applicable | Not Recruiting | No Results Available | 06/06/2018 | 16 July 2018 | Details |
| L0799 | IRCT20130126012278N3 | Phase 2 | Not Recruiting | No Results Available | 21/02/2018 | 26 March 2018 | Details |
| L0807 | IRCT2017042824198N2 | Phase 3 | Recruiting | No Results Available | 19/11/2017 | 22 February 2018 | Details |
| L0816 | IRCT201705309472N13 | Phase 2/Phase 3 | Recruiting | No Results Available | 26/07/2017 | 22 February 2018 | Details |
| L0822 | IRCT2016040318124N3 | Phase 3 | Not Recruiting | No Results Available | 28/04/2017 | 22 February 2018 | Details |
| L0825 | IRCT201405251485N13 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 14/03/2017 | 22 February 2018 | Details |
| L0826 | IRCT2017012232109N1 | Phase 2 | Not Recruiting | No Results Available | 12/03/2017 | 22 February 2018 | Details |
| L0830 | IRCT2017011531958N1 | Phase 2 | Not Recruiting | No Results Available | 20/02/2017 | 22 February 2018 | Details |
| L0837 | NCT02974374 | Phase 1 | Not recruiting | No Results Available | 11/10/2016 | 8 January 2018 | Details |
| L0839 | IRCT2016082429508N1 | Phase 2 | Not Recruiting | No Results Available | 20/09/2016 | 22 February 2018 | Details |
| L0840 | IRCT2016080614882N4 | Not applicable | Not Recruiting | No Results Available | 17/09/2016 | 22 February 2018 | Details |
| L0842 | IRCT2015122125641N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 31/08/2016 | 22 February 2018 | Details |
| L0845 | EUCTR2016-000685-39-GB | Phase 2 | Not Recruiting | No Results Available | 22/07/2016 | 8 June 2020 | Details |
| L0846 | IRCT2016042827652N1 | Phase 3 | Not Recruiting | No Results Available | 04/05/2016 | 22 February 2018 | Details |
| L0851 | IRCT201511233664N16 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 08/02/2016 | 22 February 2018 | Details |
| L0853 | IRCT2016010411991N3 | Not applicable | Not Recruiting | No Results Available | 22/01/2016 | 22 February 2018 | Details |
| L0854 | IRCT2015122525641N2 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 16/01/2016 | 22 February 2018 | Details |
| L0861 | IRCT2015092924262N1 | Not applicable | Not Recruiting | No Results Available | 25/10/2015 | 22 February 2018 | Details |
| L0870 | IRCT201503273320N11 | Not applicable | Not Recruiting | No Results Available | 27/07/2015 | 18 June 2018 | Details |
| L0872 | IRCT2015062922977N1 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 20/07/2015 | 22 February 2018 | Details |
| L0873 | IRCT201506222480N6 | Phase 3 | Not Recruiting | No Results Available | 12/07/2015 | 22 February 2018 | Details |
| L0874 | IRCT201312132480N5 | Phase 3 | Not Recruiting | No Results Available | 11/07/2015 | 22 February 2018 | Details |
| L0875 | IRCT201503163320N10 | Not applicable | Not Recruiting | No Results Available | 02/07/2015 | 22 February 2018 | Details |
| L0883 | NCT02491229 | Not applicable | Not recruiting | No Results Available | 03/02/2015 | 25 January 2016 | Details |
| L0887 | IRCT2014110819853N1 | Not applicable | Not Recruiting | No Results Available | 18/12/2014 | 22 February 2018 | Details |
| L0889 | NTR4913 | Not applicable | Not Recruiting | No Results Available | -- | -- | Details |
| L0893 | ChiCTR-TRC-14004660 | Post-market | Not Recruiting | No Results Available | 21/09/2014 | 18 April 2017 | Details |
| L0894 | IRCT2013102015083N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 01/09/2014 | 22 February 2018 | Details |
| L0899 | IRCT2014020516491N1 | Not applicable | Not Recruiting | No Results Available | 09/06/2014 | 22 February 2018 | Details |
| L0903 | NCT02690792 | Not applicable | Not recruiting | No Results Available | 17/03/2014 | 12 December 2020 | Details |
| L0909 | IRCT2013071313984N1 | Phase 2 | Not Recruiting | No Results Available | 18/12/2013 | 22 February 2018 | Details |
| L0922 | IRCT2013021012421N1 | Phase 2 | Not Recruiting | No Results Available | 05/05/2013 | 22 February 2018 | Details |
| L0927 | ACTRN12612001135808 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 24/10/2012 | 13 January 2020 | Details |
| L0938 | EUCTR2012-001371-37-DK | Phase 4 | Not Recruiting | No Results Available | 09/07/2012 | 10 December 2019 | Details |
| L0946 | IRCT201111022709N20 | Not applicable | Not Recruiting | No Results Available | 26/12/2011 | 22 February 2018 | Details |
| L0952 | IRCT201102235893N1 | Not applicable | Not Recruiting | No Results Available | 30/07/2011 | 22 February 2018 | Details |
| L0954 | IRCT201105084849N2 | Phase 3 | Not Recruiting | No Results Available | 28/05/2011 | 22 February 2018 | Details |
| L0963 | EUCTR2009-015703-13-DE | Not applicable | Not Recruiting | No Results Available | 02/11/2009 | 17 December 2012 | Details |
| L0967 | EUCTR2008-008275-34-GB | Phase 3 | Not Recruiting | No Results Available | 06/07/2009 | 25 November 2019 | Details |
| L0991 | NCT04091061 | Phase 1 | Completed | Has Results | October 3, 2019 | April 13, 2021 | Details |
| L0999 | EUCTR2019-002324-32-BE | Phase 2 | -- | -- | 2019/12/13 | -- | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | Details |
| A00023 | 35251371 | Dis Markers | Dose-Response Associations of Metabolic Score for Insulin Resistance Index with Nonalcoholic Fatty Liver Disease among a Nonobese Chinese Population: Retrospective Evidence from a Population-Based Cohort Study. | Details |
| A00029 | 35250856 | Front Endocrinol (Lausanne) | Not Enough Fat: Mouse Models of Inherited Lipodystrophy. | Details |
| A00034 | 35249505 | Curr Drug Saf | Pioglitazone, Bladder Cancer and the Presumption of Innocence. | Details |
| A00035 | 35249343 | Ann Palliat Med | Serum level of free thyroxine is an independent risk factor for non-alcoholic fatty liver disease in euthyroid people. | Details |
| A00065 | 35233386 | J Clin Transl Hepatol | Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease. | Details |
| A00078 | 35229183 | Pediatr Radiol | Diagnostic performance of ultrasound hepatorenal index for the diagnosis of hepatic steatosis in children. | Details |
| A00088 | 35223941 | Front Nutr | Cumulative Betel Quid Chewing and the Risk of Significant Liver Fibrosis in Subjects With and Without Metabolic Syndrome. | Details |
| A00101 | 35219732 | Eur J Pharmacol | mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis. | Details |
| A00111 | 35216753 | Lancet Digit Health | Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study. | Details |
| A00121 | 35213002 | Methods Mol Biol | Analysis of the Sphingolipidome in NAFLD. | Details |
| A00155 | 35206988 | Healthcare (Basel) | Effects of Different Scan Projections on the Quantitative Ultrasound-Based Evaluation of Hepatic Steatosis. | Details |
| A00157 | 35204710 | Biomolecules | Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases. | Details |
| A00158 | 35204522 | Diagnostics (Basel) | A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer. | Details |
| A00163 | 35203662 | Biomedicines | The Concept of Indeterminable NASH Inducted by Preoperative Diet and Metabolic Surgery: Analyses of Histopathological and Clinical Features. | Details |
| A00180 | 35196341 | PLoS One | The impact of background liver disease on the long-term prognosis of very-early-stage HCC after ablation therapy. | Details |
| A00208 | 35185803 | Front Endocrinol (Lausanne) | Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease. | Details |
| A00218 | 35180651 | Pathol Res Pract | Stage-dependent expression of fibrogenic markers in alcohol-related liver disease. | Details |
| A00220 | 35178663 | Hepatol Int | Distinctive clinical and genetic features of lean vs overweight fatty liver disease using the UK Biobank. | Details |
| A00247 | 35167194 | J Diabetes Investig | Fatty liver with metabolic disorder, such as metabolic dysfunction-associated fatty liver disease, indicates high risk for developing diabetes mellitus. | Details |