| Trial ID: | L0570 |
| Source ID: | IRCT2015052322381N1
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| Associated Drug: |
Curcumin
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| Title: |
Evaluation of effect of Curcumin on the serum levels of 12-inflammatory cytokines and highly sensitive C-reactive protein level in the patients with Non-alcoholic fatty liver disease (A double-blind, randomized, placebo-controlled trial)
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| Acronym: |
--
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| Status: |
Not Recruiting
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| Study Results: |
No Results Available
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| Results: |
--
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| Conditions: |
NAFLD. <br>nonalcoholic steatohepatitis;K75.8
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| Interventions: |
Intervention 1: Curcumin Phytosome (Meriva) with dose 250 mg/day (phospholipidated curcumin, 250 mg equivalent to 50 mg curcumin). Intervention 2: Curcumin C3 complexTM (500 mg) plus BioperineTM (5 mg, patented extract obtained from black pepper fruits (P
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| Outcome Measures: |
NAFLD grade. Timepoint: Before intervention and two months after intervention. Method of measurement: Sonography.;Tumor necrosis factor alpha (TNF-a). Timepoint: Before intervention and two months after intervention. Method of measurement: ELISA.;High-sensitivity C-reactive Protein (hs-CRP). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto-analyzer BT-2000.;Interleukin 6 (IL-6). Timepoint: Before intervention and two months after intervention. Method of measurement: ELISA.;Interleukin 10 (IL-10). Timepoint: Before intervention and two months after intervention. Method of measurement: ELISA.;Monocyte Chemoattractant Protein-1 (MCP-1). Timepoint: Before intervention and two months after intervention. Method of measurement: ELISA.Aspartate Aminotransferase (AST). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Alanine Aminotransferase (ALT). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Alkaline Phosphatase (ALP). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Fasting blood sugar (FBS). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Triglyceride (TG). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Total cholesterol (TC). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;High-density lipoprotein cholesterol (HDL-C). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.;Low-density lipoprotein cholesterol (HDL-C). Timepoint: Before intervention and two months after intervention. Method of measurement: Auto Analyzer BT-2000.
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| Sponsor/Collaborators: |
Neyshabour University of Medical Sciences
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| Gender: |
All
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| Age: |
15 years65 years
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| Phases: |
Phase 3
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| Enrollment: |
43
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| Study Type: |
interventional
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| Study Designs: |
Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Two letters were prepared and written on two sheets ?€?A?€? for ?€?curcumin?€? and ?€?B?€? for ?€?control.?€? AABB, AB
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| Start Date: |
17/09/2016
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| Completion Date: |
--
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| Results First Posted: |
--
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| Last Update Posted: |
5 November 2019
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| Locations: |
Iran (Islamic Republic of)
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| URL: |
http://en.irct.ir/trial/19311
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