| Trial ID: | L0703 |
| Source ID: | KCT0004923
|
| Associated Drug: |
Empagliflozin
|
| Title: |
Effects of GLP-1 Receptor Agonists on Bile Acid Metabolism and Intestinal Microorganisms: Identification of Association with Nonalcoholic Fatty Liver
|
| Acronym: |
--
|
| Status: |
Recruiting
|
| Study Results: |
No Results Available
|
| Results: |
--
|
| Conditions: |
;Endocrine, nutritional and metabolic disease
|
| Interventions: |
Drug : For type 2 diabetes patients with insufficient blood glucose control with metformin and sulfonlyurea 2 therapy, the drug is 1:1 randomly assigned to the group Dulaglutide (GLP-1 receptor agonist) and Empaglifluzin (SGLT2 inhibitor) and the drug is
|
| Outcome Measures: |
Change in severity of fatty liverChanges in body mass index, waist circumference and body mass;Comparison before and after treatment of fasting blood glucose, glycated albumin, glycated hemoglobin;internal fat area change;Changes in insulin resistance and secretion;Change of Lipid profile;Change of AST, ALT, Total bilirubin;Change of hs-crp, leptin, adiponectin, TNF-a, IL-6;Change of primary bile acid and secondary bile acid;Comparison of microbial cluster changes in intestinal excretion
|
| Sponsor/Collaborators: |
Kyung Hee University Hosipital at Gangdong
|
| Gender: |
All
|
| Age: |
20(Year)75(Year)
|
| Phases: |
Not applicable
|
| Enrollment: |
22
|
| Study Type: |
Interventional Study
|
| Study Designs: |
Primary Purpose : Treatment, Intervention Model : Parallel, Blinding/Masking : Open, Allocation : RCT
|
| Start Date: |
16/04/2020
|
| Completion Date: |
--
|
| Results First Posted: |
16/04/2020
|
| Last Update Posted: |
21 April 2020
|
| Locations: |
Korea, Republic of
|
| URL: |
http://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=15999
|
