| Trial ID: | L0732 |
| Source ID: | NCT04074889
|
| Associated Drug: |
Probiotic
|
| Title: |
Study of the Effect of Probiotics on the Clinical Outcomes and Gut Microenvironment in Patients With Non-alcoholic Fatty Liver Disease: a Randomised Controlled Trial
|
| Acronym: |
--
|
| Status: |
Recruiting
|
| Study Results: |
No Results Available
|
| Results: |
--
|
| Conditions: |
Non-Alcoholic Fatty Liver Disease
|
| Interventions: |
Dietary Supplement: (Microbial cell preparation) Probiotics;Other: Placebo
|
| Outcome Measures: |
Mean difference in hepatic steatosis scoreMean difference in hepatic fibrosis score;Mean difference in hepatic steatosis, inflammation and fibrosis scores;Microbiota composition of small intestine;Mean difference of immunoreactivity score of zona occludens-1 (ZO-1: indicator of intestinal permeability) and CD4+,CD8+, IL-8 (indicator of intestinal mucosal immune system).;Mean difference in mRNA expression of genes related to inflammation (IL-6, TNF-alpha, IFN-gamma)
|
| Sponsor/Collaborators: |
Universiti Kebangsaan Malaysia Medical Centre
|
| Gender: |
All
|
| Age: |
18 Yearsnan
|
| Phases: |
Not applicable
|
| Enrollment: |
48
|
| Study Type: |
Interventional
|
| Study Designs: |
Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor).
|
| Start Date: |
29/08/2019
|
| Completion Date: |
--
|
| Results First Posted: |
--
|
| Last Update Posted: |
12 December 2020
|
| Locations: |
Malaysia
|
| URL: |
https://clinicaltrials.gov/show/NCT04074889
|
