| Outcome Measures: |
Change in liver fat content as measured by MRI-PDFF( proton density fat fraction). <Time frame: 24 weeks, comparison of arm A and B>Important secondary endpoint<br>Change in liver stiffness as measured by MR elastography. <Time frame: 24 weeks, comparison of arm A and B><br><br>Secondary endpoint<br>1.% change of liver fat content as measured by MRI-PDFF. <Time frame: 24 weeks, comparison of arm A and B><br>2.Change in, and % change of liver fat content as measured by MRI-PDFF. <Time frame: 24 weeks, comparison of before and after ><br>3.Change in, and % change of liver fat content as measured by MRI-PDFF. <Time frame: 48 weeks, comparison of arm A and B, and before and after ><br>4.% Change of liver stiffness as measured by MR elastography. <Time frame: 24 weeks, comparison of arm A and B><br>5.Change in, and % Change of liver stiffness as measured by MR elastography. <Time frame: 24 weeks, comparison of before and after ><br>6.Change in, and % change of liver stiffness as measured by MR elastography. <Time frame: 48 weeks, comparison of arm A and B, and before and after ><br>7.Change in, and % change of following parameters. <Time frame: 24, and 48 weeks, comparison of arm A and B, and before and after ><br>8.Change in, and % change of following parameters from 24 to 48 weeks. <Comparison of week 24 and 48, and arm A and B ><br>9.Incidence of adverse events<br><br><Parameters><br>ALT, AST, gamma-GTP, PT, TP, Alb, ChE, type IV collagen 7S, P-III-P, hyaluronic acid<br>Body weight, body mass index, west circumference, blood pressure<br>HbA1c, fasting blood glucose, glycoalbumin, insulin, HOMA-R, CPI<br>TC, HDL-C, LDL-C, TG, RLP-C<br>Serum creatinine, eGFR<br>White blood cell, red blood cell, hemoglobin, hematocrit, platelet<br>Total ketone, beta-hydroxybutyric acid, acetoacetic acid<br>Uric acid<br>BUN, Na, K, P, Ca, Mg, Fe, ferritin, bilirubin fraction<br>Urine sugar, urinary ketone body, urinary albumin<br>Visceral fat area<br>Fat accumulation content of intrahepatic<br>Body fat mass, fat-free mass, muscle mass <Arbitrary parameters>
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