| Drug ID: | Drug10 |
|---|---|
| Drug Name: | Azathioprine |
| CID: | 2265 |
| DrugBank ID: | DB00993 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03370601, , NCT02413047, , NCT06213857, , NCT02281799, , NCT03101800, , NCT04882683, , NCT03151525, , NCT00984568, , NCT02579733, , NCT01817972 |
| Molecular Formula: | C9H7N7O2S |
| Molecular Weight: | 277.27 g/mol |
| Isomeric SMILES: | CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-] |
| Synonyms: | azathioprine; 446-86-6; Azothioprine; Azathioprin; Azamun; Azanin; Azatioprin; Azasan; Ccucol; Imurek |
| Phase 0: | 3 |
| Phase 1: | 7 |
| Phase 2: | 38 |
| Phase 3: | 59 |
| Phase 4: | 44 |
| Description: | An immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt80 | 2265 | Azathioprine | 5243 | ABCB1 | Homo sapiens (human) | 17262810 | ABCB1 gene polymorphism affects the susceptibility to azathioprine |
| dt81 | 2265 | Azathioprine | 8647 | ABCB11 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCB11 mRNA |
| dt82 | 2265 | Azathioprine | 5244 | ABCB4 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCB4 mRNA |
| dt83 | 2265 | Azathioprine | 1244 | ABCC2 | Homo sapiens (human) | 22623647 | Azathioprine results in increased expression of ABCC2 mRNA |
| dt84 | 2265 | Azathioprine | 1244 | ABCC2 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC2 mRNA |
| dt85 | 2265 | Azathioprine | 8714 | ABCC3 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC3 mRNA |
| dt86 | 2265 | Azathioprine | 10257 | ABCC4 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC4 mRNA |
| dt87 | 2265 | Azathioprine | 9429 | ABCG2 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCG2 mRNA |
| dt88 | 2265 | Azathioprine | 64240 | ABCG5 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCG5 mRNA |
| dt89 | 2265 | Azathioprine | 63874 | ABHD4 | Homo sapiens (human) | 22623647 | Azathioprine results in increased expression of ABHD4 mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05584228 | Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease | NA | NOT_YET_RECRUITING | Nantes University Hospital | Crohn Disease | DRUG: Azathioprine + infliximab|PROCEDURE: Intest… | Details |
| NCT05456776 | Azathioprine Linked With Impaired Intestinal Epithelial Postoperative Regeneration in Crohn's Disease | NULL | COMPLETED | Centre of Postgraduate Medical Education | Inflammatory Bowel Diseases | None | Details |
| NCT05321485 | The Effect of MedicijnWijs on Adherence to Azathioprine Therapy in Adolescents With IBD | NA | UNKNOWN | Maxima Medical Center | Inflammatory Bowel Diseases|Crohn Disease|Ulcerat… | OTHER: MedicijnWijs | Details |
| NCT07138898 | Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty | PHASE2 | NOT_YET_RECRUITING | NYU Langone Health | Rheumatic Disease | DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Hydr… | Details |
| NCT05040464 | Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial | PHASE3 | RECRUITING | Centre Hospitalier Universitaire, Amiens | Crohn Disease|Azathioprine|Methotrexate | DRUG: AZA capsules|DRUG: MTX|BIOLOGICAL: blood sa… | Details |
| NCT04882683 | Clinical Study of Cord Blood Mononuclear Cells on Treatment of Hormone-resistant or Hormone-dependent Ulcerative Colitis | NA | UNKNOWN | Shandong Qilu Stem Cells Engineering Co., Ltd. | Ulcerative Colitis | DRUG: Prednisone|DRUG: Azathioprine|DRUG: Adalimu… | Details |
| NCT04761952 | N-3 Polyunsaturated Fatty Acids Prevent Postoperative Recurrence of Crohn's Disease | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Inflammatory Bowel Diseases|Crohn Disease|Polyuns… | DRUG: azathioprine|DRUG: infliximab|DRUG: N-3 Pol… | Details |
| NCT04160325 | Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery | NA | UNKNOWN | Zhu Weiming | Crohn Disease | DIETARY_SUPPLEMENT: postoperative 3-month exclusi… | Details |
| NCT03681652 | Post-Operative Crohn's Disease Outcome in Children | NULL | RECRUITING | Schneider Children's Medical Center, Israel | Crohn Disease | DRUG: Azathioprine|DRUG: Anti-TNF Drug | Details |
| NCT03580876 | Addition of Azathioprine in IBD Patients With Immunogenic Failure | PHASE4 | UNKNOWN | Védrines, Philippe, M.D. | Clinical Failure After Switch | DRUG: addition of azathioprine|DRUG: Switch to a … | Details |
| NCT03393247 | The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on CD | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: infliximab and azathioprine combination at … | Details |
| NCT03370601 | Evaluation of the Clinical and Immunological Impact of Two Therapeutic Strategies in Chronic Inflammatory Diseases | NA | TERMINATED | University Hospital, Lille | Inflammatory Bowel Diseases | DRUG: Infliximab|DRUG: Mercaptopurine|DRUG: Azath… | Details |
| NCT03185611 | Effectiveness of Rifaximin Combined With Thiopurine on Preventing Postoperative Recurrence in Crohn's Disease | PHASE3 | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: Rifaximin|DRUG: Azathioprine | Details |
| NCT03151525 | Two Therapeutic Strategies for the Maintenance of Remission in Patients With Ulcerative Colitis | PHASE4 | UNKNOWN | Istituto Clinico Humanitas | Colitis, Ulcerative | DRUG: Azathioprine|DRUG: Infliximab | Details |
| NCT03101800 | Beneficial and Harmful Effects of Azathioprine and Allopurinol Versus Standard Azathioprine Therapy for Patients With Ulcerative Colitis | PHASE3 | UNKNOWN | Hvidovre University Hospital | Colitis, Ulcerative|Colitis Ulcerative Exacerbati… | DRUG: Azathioprine and Allopurinol|DRUG: Azathiop… | Details |
| NCT02998827 | Thalidomide Results in Diminished Ovarian Reserve in Reproductive Age Female IBD Patients | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: Thalidomide|DRUG: infliximab, azathioprine|… | Details |
| NCT02929706 | Pre-genotype NUDT 15 R139C on Reducing Thiopurine-induced Leucopenia in Inflammatory Bowel Disease | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Thiopurine-induced Leukopenia | GENETIC: Pre-genotype NUDT15 and optimize azathio… | Details |
| NCT02852694 | Reduce Risk for Crohn's Disease Patients | PHASE4 | COMPLETED | PIBD-Net | Crohn's Disease | DRUG: Methotrexate|DRUG: Adalimumab|DRUG: Azathio… | Details |
| NCT02579733 | Azathioprine Based on Endoscopy After Clinical Remission in Moderate to Severe Ulcerative Colitis | PHASE4 | TERMINATED | Kyungpook National University Hospital | Ulcerative Colitis | DRUG: Azathioprine|DRUG: Placebo | Details |
| NCT02517684 | Top-down Infliximab Study in Kids With Crohn's Disease | PHASE4 | COMPLETED | Erasmus Medical Center | Crohn's Disease | DRUG: Infliximab|DRUG: Prednisolone|OTHER: Exclus… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S02 | Immunosuppression | Classic immunosuppressive drugs | azathioprine; 6-mercaptopurine; methotrexate; ciclosporin-A; tacrolimus | Ciclosporin-A and tacrolimus bind to specific intracellular… | Details |
Finding Predictors of Azathioprine-Induced Pancreatitis in Patients With Inflam…
PMID: 35584388
Year: 2022
Relationship Type:
Treatment
Score: 9.5
OBJECTIVES: Azathioprine (AZA)-induced pancreatitis (AIP) is a common, idiosyncratic adverse effect whose incidence and risk factors data in inflamma…
Azathioprine and Acenocoumarol Drug Interaction in Patients with Crohn's Diseas…
PMID: 35469571
Year: 2023
Relationship Type:
Association
Score: 9.5
BACKGROUND: Acenocoumarol is an anticoagulant with numerous drug reactions. We report here, an unusual interaction between acenocoumarol and azathiop…
Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug…
PMID: 35450035
Year: 2022
Relationship Type:
Treatment
Score: 9.5
Despite the growing number of new drugs approved for the treatment of inflammatory bowel disease (IBD), the long-term clinical use of thiopurine ther…
Mucosal healing with methotrexate versus azathioprine treatment in pediatric Cr…
PMID: 35373937
Year: 2022
Relationship Type:
Treatment
Score: 9.5
BACKGROUND/OBJECTIVES: The current treatment goal for inflammatory bowel disease (IBD) is achievement of mucosal healing (MH). While established with…
Persistently normal blood tests in patients taking methotrexate for RA or azath…
PMID: 35256384
Year: 2022
Relationship Type:
Association
Score: 9.5
BACKGROUND: Disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate and azathioprine, are commonly used to treat rheumatoid arthritis…
HLA variants associated with azathioprine-induced pancreatitis in patients with…
PMID: 35120281
Year: 2022
Relationship Type:
Association
Score: 9.5
The immunosuppressant drug azathioprine is associated with a 4% risk of acute pancreatitis in patients with inflammatory bowel disease (IBD). Studies…
Parenteral Methotrexate Is Efficient in the Treatment of Azathioprine Refractor…
PMID: 35115294
Year: 2022
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: There is limited data in the literature analyzing the efficacy of methotrexate in Crohn's disease used after thiopurine analogs. We aimed…
Sweet Syndrome Associated With Crohn's Disease Developed After a Combo Therapy …
PMID: 35111438
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Sweet syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. The exact pathogenesis of Sweet syndrome is un…
NUDT15 intermediate metabolisers are associated with lower loss of response in …
PMID: 35032047
Year: 2022
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: NUDT15 polymorphisms are associated with leukopenia during treatment with thiopurines. However, data regarding its effect on treatment ou…
Discontinuation of Azathioprine could be considered in pediatric patients with …
PMID: 35017546
Year: 2022
Relationship Type:
Treatment
Score: 9.5
Few studies have demonstrated treatment strategies about the duration and cessation of medications in patients with Crohn's disease (CD). We investig…
Azathioprine-induced alopecia: a rare adverse event, early marker of myelotoxic…
PMID: 34517716
Year: 2022
Relationship Type:
Treatment
Score: 9.5
Though not exempt from adverse events, azathioprine (AZA) is an inexpensive and effective drug in the induction and maintenance treatment of patients…
Simultaneous Monitoring of Azathioprine Metabolites in Erythrocytes of Crohn's …
PMID: 34159374
Year: 2022
Relationship Type:
Treatment
Score: 9.5
The conversion of azathioprine (AZA) to active 6-thioguanine nucleotides (6-TGN) is essential for its clinical efficacy; however, another metabolite …
Noninvasive Monitoring After Azathioprine Withdrawal in Patients With Inflammat…
PMID: 34139332
Year: 2021
Relationship Type:
Treatment
Score: 9.5
BACKGROUND & AIMS: There is uncertainty regarding the optimal duration of treatment with azathioprine (AZA) in ulcerative colitis (UC) and Crohn's di…
Ustekinumab is more effective than azathioprine to prevent endoscopic postopera…
PMID: 33951350
Year: 2021
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Preventing postoperative recurrence (POR) is a major concern in Crohn's disease (CD). While azathioprine is an option, no data is availab…
Azathioprine-induced toxoplasma gondii infection in a patient with Crohn's dise…
PMID: 33950972
Year: 2021
Relationship Type:
Treatment
Score: 9.5
INTRODUCTION: Azathioprine (AZA) has been widely used for the treatment of various immune-related diseases and has become a mainstay in the treatment…
CMV pneumonitis in a patient with Crohn's disease taking azathioprine
PMID: 33893128
Year: 2021
Relationship Type:
Treatment
Score: 9.5
This case report discusses the rare presentation of cytomegalovirus (CMV) pneumonitis in a young patient with moderately severe Crohn's disease manag…
Redox imbalance in Crohn's disease patients is modulated by Azathioprine
PMID: 33882797
Year: 2021
Relationship Type:
Treatment
Score: 9.5
BACKGROUND: Crohn's disease (CD) is a chronic inflammatory disease without a specific cause. Inflammation in these patients can disturb the oxidants/…
Development of a HPLC-DAD stability-indicating method and compatibility study o…
PMID: 33687392
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Adherence in chronic diseases is a major problem which can be combated by prescribing fixed-dose combinations in the therapy of the disease. Thus, a …
Intrahepatic cholestasis of pregnancy associated with azathioprine: A case seri…
PMID: 33601075
Year: 2021
Relationship Type:
Association
Score: 9.5
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is characterised by otherwise unexplained maternal pruritus, increased serum bile acid concen…
Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration …
PMID: 33532511
Year: 2021
Relationship Type:
Treatment
Score: 9.5
Posterior reversible encephalopathy syndrome is a rare syndrome characterized by brain edema and neurological symptoms, often resulting from several …