| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regul…
PMID: 37903267
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in …
Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis v…
PMID: 37749885
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis enables the establishment of a harmonious gut microenvironmen…
Primary colonic MALT lymphoma associated with Crohn's disease: Case report and …
PMID: 37251745
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
KEY CLINICAL MESSAGE: To date, the pathogenic mechanisms of the association between Crohn's disease and MALT lymphoma are ambiguous and yet remain to…
Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic T…
PMID: 36613488
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Akkermansia muciniphila is a mucosal symbiont considered a gut microbial marker in healthy individuals, as its relative abundance is significantly re…
Glutamine alleviates intestinal injury in a murine burn sepsis model by maintai…
PMID: 36566008
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal intraepithelial lymphocytes (IELs) play a sentinel role in the mucosal immune system because of their unique anatomical location in the ep…
Regulatory T cell homeostasis: Requisite signals and implications for clinical …
PMID: 36470337
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Novel biologics are currently being tested in clinical trials for the treatment of autoimmune diseases and the prevention of transplant allograft rej…
Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and L…
PMID: 36145301
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel diseases (IBDs) are characterized by chronic inflammatory disorders that are a result of an abnormal immune response mediated by a…
Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology
PMID: 35707544
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Group 2 innate lymphoid cells (ILC2s) were identified in 2010 as a novel lymphocyte subset lacking antigen receptors, such as T-cell or B-cell recept…
Role of Interleukin-17A in the Pathomechanisms of Periodontitis and Related Sys…
PMID: 35371044
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Periodontitis is a chronic inflammatory and destructive disease caused by periodontal microbial infection and mediated by host immune response. As th…
Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation With Neutrop…
PMID: 34643647
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
IMPORTANCE: Pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND) is a monogenic autoinflammatory disorder with autosomal dominant i…
The Multifaceted Role of Serotonin in Intestinal Homeostasis
PMID: 34502396
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide rang…
Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease
PMID: 34299236
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Complex interactions between the environment and the mucosal immune system underlie inflammatory bowel disease (IBD). The involved cytok…
How the AHR Became Important in Intestinal Homeostasis-A Diurnal FICZ/AHR/CYP1A…
PMID: 32784381
Year: 2020
Relationship Type:
Drug Development
Score: 5.8
Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydro…
High-mobility Group Box 1 Facilitates CD4 T Cell Self-aggregation Via Integrin …
PMID: 32130404
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: High-mobility group box 1 (HMGB1) is one of the delayed pro-inflammatory cytokines produced in the later stages of pathogenesis and plays…
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling…
PMID: 31211700
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Resident microbiota activate regulatory cells that modulate intestinal inflammation and promote and maintain intestinal homeostasis. IL-10 is a key m…
Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in In…
PMID: 30544952
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory bowel disease, rheumatoid arthritis, and chronic kidney disea…
Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoi…
PMID: 29737384
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
The gastrointestinal tract is the primary site of exposure to a multitude of microbial, environmental, and dietary challenges. As a result, immune re…
Essential immunologic orchestrators of intestinal homeostasis
PMID: 29440266
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
Over the past 25 years, substantial advances have been made in our understanding of the cellular and molecular pathways that are essential to maintai…
Maintenance of macrophage transcriptional programs and intestinal homeostasis b…
PMID: 28783698
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Epigenetic "readers" that recognize defined posttranslational modifications on histones have become desirable therapeutic targets for cancer and infl…
Homology modeling and in silico prediction of Ulcerative colitis associated pol…
PMID: 28578011
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Cytosolic pattern recognition receptors play key roles in innate immune response. Nucleotide binding and oligomerisation domain containing protein 1 …
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||