| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effect…
PMID: 28221249
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: The precise mechanisms controlling homing of T effector (Teff) cells to the inflamed gut in Crohn's disease (CD) are still unclear, and c…
Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating…
PMID: 27982094
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, th…
Demethyleneberberine alleviates inflammatory bowel disease in mice through regu…
PMID: 27900412
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVE: The activation of NF-kappaB signaling and unbalance of T-helper (Th) cells have been reported to play a key role in the pathogenesis of co…
Different tissue phagocytes sample apoptotic cells to direct distinct homeostas…
PMID: 27828940
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and…
High fat diet exacerbates dextran sulfate sodium induced colitis through distur…
PMID: 27567245
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Erratum in Sci Rep. 2020 Nov 10;10(1):19885. Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and pr…
Deficiency in Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1: A Nov…
PMID: 27253662
Year: 2017
Relationship Type:
Target Validation
Score: 5.8
OBJECTIVE: Early-onset inflammatory bowel diseases can result from a wide spectrum of rare mendelian disorders. Early molecular diagnosis is crucial …
Recent Advances and Understanding of Using Probiotic-Based Interventions to Res…
PMID: 27227298
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
The importance of the microbiome in health and disease has galvanized interest in using manipulations of the gastrointestinal ecosystem to prevent an…
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epitheli…
PMID: 26655906
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Microbial pattern molecules in the intestine play immunoregulatory roles via diverse pattern recognition receptors. However, the role of the cytosoli…
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th…
PMID: 26561545
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
IL-1R-associated kinase (IRAK) 1 is an important component of the IL-1R and TLR signaling pathways, which influence Th cell differentiation. In this …
Immunopathogenesis of inflammatory bowel diseases: functional role of T cells a…
PMID: 26458165
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel diseases (IBD) are believed to arise from a complex interplay of environmental factors, genetic susceptibility, epithelial barrier…
MicroRNAs and the regulation of intestinal homeostasis
PMID: 25324861
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
The mammalian intestinal tract is a unique site in which a large portion of our immune system and the 10(14) commensal organisms that make up the mic…
C/EBP homologous protein inhibits tissue repair in response to gut injury and i…
PMID: 24850428
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
Loss of intestinal epithelial cell (IEC) homeostasis and apoptosis negatively affect intestinal barrier function. Uncontrolled activation of the unfo…
Immuno-inhibitory PD-L1 can be induced by a peptidoglycan/NOD2 mediated pathway…
PMID: 22397822
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
Peptidoglycan (PGN) is a ubiquitous bacterial membrane product that, despite its well known pro-inflammatory properties, has also been invoked in imm…
Prognosis of lymphoma in patients following treatment with 6-mercaptopurine/aza…
PMID: 22241664
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammatory disorders of the gastrointestinal tract, and includes two major …
A humanized monoclonal antibody targeting the β7 integrin selectively blocks in…
PMID: 21232034
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND AND PURPOSE: rhuMAb Beta7 is a humanized anti-human beta7 monoclonal antibody currently in phase I in inflammatory bowel disease. rhuMAb B…
Intestinal dendritic cells: their role in bacterial recognition, lymphocyte hom…
PMID: 20222140
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.8
Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the bal…
Genistein maintains intestinal homeostasis in colitis mice via activating GPR30…
PMID: 40684867
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.5
Genistein (GEN) is a natural polyphenolic compound widely present in leguminous plants, which has many biological functions such as anti-inflammatory…
Restraint Stress Disrupted Intestinal Homeostasis via 5-HT/HTR7/Wnt/β-Catenin/N…
PMID: 40362261
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.5
Stress may aggravate the development of inflammatory bowel disease and irritable bowel syndrome, in which the number of enterochromaffin (EC) cells a…
cGAS-STING signaling pathway in intestinal homeostasis and diseases
PMID: 37781354
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.5
The intestinal mucosa is constantly exposed to commensal microbes, opportunistic pathogens, toxins, luminal components and other environmental stimul…
Identification of Cholesterol Homeostasis Related Genes and Potential Pathogene…
PMID: 40645380
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND AND AIMS: Cholesterol metabolism (CM) plays essential roles in human disease. Ulcerative colitis (UC) is a chronic inflammatory bowel dise…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||