| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
PMID: 40613233
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its p…
Coptis chinensis-derived extracellular vesicle-like nanoparticles delivered miR…
PMID: 40517238
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic disorder marked by persistent inflammation and damage to the intestinal mucosa. Despite sig…
The impact of climate, weather, seasonal transitions, and diurnal rhythms on gu…
PMID: 40450648
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
The influence of meteorological environmental factors such as climate change, weather alterations, seasonal transitions, and diurnal cycles on human …
α1,3 Fucosyltransferase VII Improves Intestinal Immune Homeostasis in Inflammat…
PMID: 40180293
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND & AIMS: Regulatory T cells (Tregs) play a critical role in maintaining tissue immune homeostasis, but they are relatively insufficient at …
Transcription factor ELF-1 protects against colitis by maintaining intestinal e…
PMID: 40057592
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. …
Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Ma…
PMID: 40047584
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) compromises the intestinal barrier and disrupts gut microbiota, impacting liver function via the gut-liver axis, whi…
Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- …
PMID: 40034858
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal epithelium regeneration and homeostasis must be tightly regulated. Alteration of epithelial homeostasis is a major contributing factor to …
Chemotaxis-driven hybrid liposomes recover intestinal homeostasis for targeted …
PMID: 39961435
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is closely linked to the dysregulation of intestinal homeostasis, accompanied by intestinal epithelial barrier destr…
Yeast-Inspired Orally-Administered Nanocomposite Scavenges Oxidative Stress and…
PMID: 39943645
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Excessive oxidative stress, dysregulated immune homeostasis, and disruption of the intestinal epithelial barrier are crucial features of inflammatory…
Gut-homing and intestinal TIGIT(neg)CD38(+) memory T cells acquire an IL-12-ind…
PMID: 39586377
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
CD4(+) memory T cell (T(M)) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis…
Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute…
PMID: 39545264
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The im…
Homocysteine aggravates intestinal inflammation through promotion of 5-LOX and …
PMID: 39506850
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Homocysteine (Hcy) is a pro-inflammatory molecule that has the potential to induce oxidative damage to cells and stimulate the release of…
Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel dise…
PMID: 39095853
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Monocytes and macrophages play an indispensable role in maintaining intestinal homeostasis and modulating mucosal immune responses in inf…
Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut…
PMID: 38987259
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on …
The intestinal microbial metabolite acetyl l-carnitine improves gut inflammatio…
PMID: 38369215
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal symbiotic bacteria play a key role in the regulation of immune tolerance in inflammatory bowel disease (IBD) hosts. However, the bacterial…
Transcription factor EB modulates the homeostasis of reactive oxygen species in…
PMID: 38342419
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Transcription factor EB (TFEB), a master lysosomal biogenesis and autophagy regulator, is crucial for cellular homeostasis, and its abnormality is re…
Immune cell-derived signals governing epithelial phenotypes in homeostasis and …
PMID: 38320941
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regula…
Cortical structural changes of morphometric similarity network in early-onset s…
PMID: 38049797
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring the association …
Adaptive Nanoparticle-Mediated Modulation of Mitochondrial Homeostasis and Infl…
PMID: 37930276
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Infected bone defects (IBDs) exhibit impaired healing due to excessive inflammation triggered by pathogen-associated molecular patterns (PAMPs) from …
Plasma-Activated Solutions Mitigates DSS-Induced Colitis via Restoring Redox Ho…
PMID: 37870220
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Ulcerative colitis is a chronic disease that increases the risk of developing colorectal cancer. Conventional medications are limited by drug deliver…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||