| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dex…
PMID: 37704122
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Shen-Ling-Bai-Zhu-San (SLBZS) is a classic formula for strengthening the spleen and dispelling dampness, which has sh…
Epithelial TNF controls cell differentiation and CFTR activity to maintain inte…
PMID: 37643009
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The gastrointestinal tract relies on the production, maturation, and transit of mucin to protect against pathogens and to lubricate the epithelial li…
GPR35-mediated kynurenic acid sensing contributes to maintenance of gut microbi…
PMID: 37423235
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. Metabolites and their sensors play an important role …
The molecular insights of bile acid homeostasis in host diseases
PMID: 37422071
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Bile acids (BAs) function as detergents promoting nutrient absorption and as hormones regulating nutrient metabolism. Most BAs are key regulatory fac…
Modulation of stem cell fate in intestinal homeostasis, injury and repair
PMID: 37342221
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The mammalian intestinal epithelium constitutes the largest barrier against the external environment and makes flexible responses to various types of…
Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for…
PMID: 37265165
Year: 2024
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: Therapeutic drug monitoring provides important guidance for treatment of patients with inflammatory bowel disease (IBD) and could help to…
Macrophages in intestinal homeostasis and inflammatory bowel disease
PMID: 37069320
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be drivers of inflammation in the context of inflammatory bowe…
Ginseng-Containing Sijunzi Decoction Ameliorates Ulcerative Colitis by Orchestr…
PMID: 36883990
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) has become a global epidemic, and the lack of an effective cure highlights the necessity and urgency to explore novel therapi…
Impact of IBD-Associated Dysbiosis on Bacterial Quorum Sensing Mediated by Acyl…
PMID: 36499731
Year: 2022
Relationship Type:
Clinical Research
Score: 5.3
Intestinal dysbiosis is a key feature in the pathogenesis of inflammatory bowel disease (IBD). Acyl-homoserine lactones (AHL) are bacterial quorum-se…
Microplastics perturb colonic epithelial homeostasis associated with intestinal…
PMID: 36410465
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
A great amount of the population died due to living or working in an unhealthy environment, highlighting the critical role of environmental pollutant…
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in i…
PMID: 36270778
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is stil…
Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiti…
PMID: 36211988
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Homoharringtonine (HHT) exhibits an anti-inflammatory activity. The potential protective effects and mechanisms of HHT on dextran sulfate sodium- (DS…
Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid…
PMID: 36054406
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The correlation of bile acid (BA) metabolism disorder with the pathogenesis of ulcerative colitis (UC) is realized nowadays. Farnesoid X receptor (FX…
Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice
PMID: 36048018
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Group 3 innate lymphoid cells (ILC3s) are crucial for the maintenance of host-microbiota homeostasis in gastrointestinal mucosal tissues. The mechani…
Sympathetic Innervation Modulates Mucosal Immune Homeostasis and Epithelial Hos…
PMID: 36010681
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal mucosal cells, such as resident macrophages and epithelial cells, express adrenergic receptors and are receptive to norepinephrine, the pr…
NF-κB Inducing Kinase Regulates Intestinal Immunity and Homeostasis
PMID: 35833111
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal immunity and homeostasis are maintained through the regulation of cytokine trafficking, microbiota, necrosis and apoptosis. Intestinal imm…
Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1…
PMID: 35585977
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
TNFalpha converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and …
EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keep…
PMID: 35493520
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
EpCAM deficiency causes congenital tufting enteropathy (CTE) which is considered as one kinds of very early onset inflammatory bowel disease (IBD). H…
Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice
PMID: 35357446
Year: 2022
Relationship Type:
Correlation Studies
Score: 5.3
The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomato…
Cyclic GMP-AMP synthase contributes to epithelial homeostasis in intestinal inf…
PMID: 35344224
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) represents a set of idiopathic and chronic inflammatory diseases of the gastrointestinal tract. Central to the patho…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||