| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Guanylin and uroguanylin: a promising nexus in intestinal electrolyte and fluid…
PMID: 35158329
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal guanyl peptides like guanylin and uroguanylin are the potent regulators of fluid-ion homeostasis. They are secreted from various cells of …
Point-of-Care Testing and Home Testing: Pragmatic Considerations for Widespread…
PMID: 34995530
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Breaking through the biologic therapy efficacy plateau for inflammatory bowel disease requires the strategic development of personalized biomarkers i…
Excessive Apoptosis in Ulcerative Colitis: Crosstalk Between Apoptosis, ROS, ER…
PMID: 34871402
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is characterized by the damage of mucosal epithelium an…
Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in mai…
PMID: 34493329
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the i…
The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastrointestin…
PMID: 34054805
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
The large surfaces of gastrointestinal (GI) organs are well adapted to their diverse tasks of selective nutritional uptake and defense against the ex…
MALAT1 Maintains the Intestinal Mucosal Homeostasis in Crohn's Disease via the …
PMID: 33677577
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Intestinal homeostasis disorder is critical for developing Crohn's disease [CD]. Maintaining mucosal barrier integrity is essent…
Expression of MAdCAM-1 and Gut-homing T Cells in Inflamed Pouch Mucosa
PMID: 33675360
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Pouchitis is a common complication following formation of an ileal pouch-anal anastomosis [IPAA] after proctocolectomy for ulcer…
Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune…
PMID: 33593426
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Lactobacillus reuteri strains are widely used as probiotics to prevent and treat inflammatory bowel disease by modulating the host's immu…
Single Nucleotide Polymorphisms Associated With Gut Homeostasis Influence Risk …
PMID: 33328979
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Research is increasingly focusing on gut inflammation as a contributor to Parkinson's disease (PD). Such gut inflammation is proposed to arise from a…
The novel ECF56 SigG1-RsfG system modulates morphological differentiation and m…
PMID: 33303917
Year: 2020
Relationship Type:
Correlation Studies
Score: 5.3
Obesity is a major health problem worldwide. Overweight and obesity directly affect health-related quality of life and also have an important econom…
Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fat…
PMID: 33051755
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
The rapid renewal of intestinal epithelium is mediated by a pool of stem cells, located at the bottom of crypts, giving rise to highly proliferative …
Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced …
PMID: 33022343
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a relapsing inflammatory disease that still demands for effective remedies due to various …
Retinoid-Related Orphan Receptor RORγt in CD4(+) T-Cell-Mediated Intestinal Hom…
PMID: 32735890
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Retinoic acid-related orphan receptor (ROR)-gammat, the master transcription factor of the Th17 subset of CD4(+) Th cells, is a promising target for …
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 an…
PMID: 32457736
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, local…
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLK…
PMID: 32362323
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Pathways controlling intestinal epithelial cell (IEC) death regulate gut immune homeostasis and contribute to the pathogenesis of inflammatory bowel …
Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis
PMID: 32304780
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a…
Neuro-Immune Circuits Regulate Immune Responses in Tissues and Organ Homeostasis
PMID: 32265899
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
The dense innervation of the gastro-intestinal tract with neuronal networks, which are in close proximity to immune cells, implies a pivotal role of …
Therapeutic Potential of Lipoxin A(4) in Chronic Inflammation: Focus on Cardiom…
PMID: 32259087
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Several studies have shown that failure to resolve inflammation may contribute to the progression of many chronic inflammatory disorders. It has been…
Thiol-disulfide homeostasis: an integrated approach with biochemical and clinic…
PMID: 32233181
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins an…
Regulating colonic dendritic cells by commensal glycosylated large surface laye…
PMID: 31619761
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Microbial interaction with the host through sensing receptors, including SIGNR1, sustains intestinal homeostasis against pathogenic inflammation. The…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||