| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Rotavirus Reprograms Multiple Interferon Receptors and Restricts Their Intestin…
PMID: 31896593
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Rotaviruses (RV) cause acute severe diarrhea in the absence of substantial intestinal inflammation. They are also highly infectious in their homologo…
RM, a novel resveratrol derivative, attenuates inflammatory responses induced b…
PMID: 31835082
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Although the novel resveratrol derivative RM has therapeutic potential for the treatment of inflammatory bowel disease, little is currently known reg…
Beclomethasone dipropionate in microscopic colitis: Results of an exploratory o…
PMID: 31700631
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
A complex bidirectional communication system exists between the gastrointestinal tract and the brain. Initially termed the "gut-brain axis" it is no…
Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccha…
PMID: 31473900
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
Immune-mediated diseases (IMDs) arise when tolerance is lost and chronic inflammation is targeted towards healthy tissues. Despite their growing pr…
Miltefosine treatment reduces visceral hypersensitivity in a rat model for irri…
PMID: 31467355
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and …
Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection…
PMID: 31442399
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitio…
Anhedonia in irritable bowel syndrome and in inflammatory bowel diseases and it…
PMID: 30628137
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
INTRODUCTION: Glucagon like-peptide 1 receptor (GLP-1R) agonists diminish appetite and may contribute to the weight loss in inflammatory bowel disea…
Lipidic prodrug approach for improved oral drug delivery and therapy
PMID: 30320896
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
In the past, a prodrug design was used as a last option to improve bioavailability through controlling transport, distribution, metabolism, or other …
Predicting Risk of Postoperative Disease Recurrence in Crohn's Disease: Patient…
PMID: 29982468
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
Background: Enterochromaffin cells (EC) synthesize and release 5-HT and ATP to trigger or modulate gut neural reflexes and transmit information abou…
Panax notoginseng for Inflammation-Related Chronic Diseases: A Review on the Mo…
PMID: 29976083
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
Panax notoginseng (P. notoginseng) is a well-known and commonly used Chinese herbal medicine in Asian countries. As one of the major species in the P…
[Medication regularity and potential targets of Professor XU Jing-fan's prescri…
PMID: 29676106
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and qualit…
Design of a "Mini" Nucleic Acid Probe for Cooperative Binding of an RNA-Repeate…
PMID: 29334465
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
This study aims to evaluate the in vitro cytotoxic and anti-migratory effects of Ficus deltoidea L. on prostate cancer cells, identify the active co…
Administration of Protein Kinase D1 Induces a Protective Effect on Lipopolysacc…
PMID: 29225991
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.3
The vagus nerve (VN) is the longest nerve of the organism and a major component of the parasympathetic nervous system which constitutes the autonomi…
Quantifying connectivity between local Plasmodium falciparum malaria parasite p…
PMID: 29077712
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.3
Advances in human genetics have dramatically expanded our understanding of complex heritable diseases. Genome-wide association studies have identifi…
A Systems Pharmacology Approach to Determine Active Compounds and Action Mechan…
PMID: 28446747
Year: 2017
Relationship Type:
Target Validation
Score: 6.3
Xipayi Kui Jie'an (KJA), a type of traditional Uygur medicine (TUM), has shown promising therapeutic effects in Ulcerative colitis (UC). Owing to the…
Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multipl…
PMID: 27499754
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.3
Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl fumarate (DMF) is utilized as an oral drug to treat this disease …
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators o…
PMID: 27177092
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 6.3
To develop a nanoparticulate drug carrier for targeting of the inflamed intestinal mucosa, amphiphilic hyaluronic acid (HA) conjugates were synthesi…
Specific members of the predominant gut microbiota predict pouchitis following …
PMID: 26423113
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.3
A growing body of evidence suggests that activation of nuclear factor kappa B (NF-κB) signaling pathways is among the inflammatory mechanism involve…
Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Commun…
PMID: 26224864
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilit…
Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inf…
PMID: 26167076
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
AIM: To investigate the inhibitory effects and mechanism of high mobility group box (HMGB)1 A-box in lipopolysaccharide (LPS)-induced intestinal infl…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||