| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Application of Comparative Transcriptional Genomics to Identify Molecular Targe…
PMID: 26085826
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
INTRODUCTION: The incidence of Inflammatory Bowel Diseases (IBD) is rising and overall epidemiology is changing. Goals of IBD therapy are also fast …
Direct retrospective comparison of adalimumab and infliximab in preventing earl…
PMID: 25820017
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: The precise role of microRNAs in inflammatory disease is not clear. The present study investigated the effect of microRNA (miR-146b) wit…
Development of therapies for autoimmune disease at Stanford: a tale of multiple…
PMID: 24771483
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 6.3
The title of this contribution on Immunology at Stanford is purposely ambiguous. One goal is the development of safe and effective therapy for autoim…
Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccha…
PMID: 22251620
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 6.3
Resveratrol, a polyphenol abundantly found in grapes and red wine, exhibits beneficial health effects due to its anti-inflammatory properties. In the…
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
PMID: 21887730
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic infla…
Alternative activation of macrophages by IL-4 requires SHIP degradation
PMID: 21469115
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 6.3
Alternatively activated macrophages are critical in host defense against parasites and are protective in inflammatory bowel disease, but contribute t…
Dipeptidyl peptidase in autoimmune pathophysiology
PMID: 21404914
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 6.3
CD26 is a 110-kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) activity that is expressed on various cell types and has many b…
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may p…
PMID: 21217010
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 6.3
We have previously demonstrated that IL-7 is essential for the persistence of colitis as a survival factor of colitogenic IL-7Ralpha-expressing memor…
Impact of lipoteichoic acid modification on the performance of the probiotic La…
PMID: 20731672
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: The proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18 are central players in the pathogenesis of inflammatory bowel disea…
Expression of inflammatory and insulin signaling genes in adipose tissue in res…
PMID: 20444921
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 6.3
CONTEXT: The mechanisms behind postoperative insulin resistance and impaired glucose utilization are not fully understood. OBJECTIVE: In this study, …
Solid lipid nanoparticles as anti-inflammatory drug delivery system in a human …
PMID: 20138213
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a markedly increased risk to develop colon cancer, but there are only limited data a…
Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, p…
PMID: 19572372
Year: 2010
Relationship Type:
Therapeutic Applications
Score: 6.3
BACKGROUND: Resolvin E1 (RvE1), an endogenous lipid mediator derived from eicosapentaenoic acid, has been identified in local inflammation during the…
Combined therapeutic approach: inflammatory bowel diseases and peripheral or ax…
PMID: 19468996
Year: 2009
Relationship Type:
Mechanism Investigation
Score: 6.3
Comment in Inflamm Bowel Dis. 2009 May;15(5):769-71. Abdominal pain is a common symptom of inflammatory bowel disease (IBD: Crohn's disease, ul…
Irritable pouch syndrome is associated with depressiveness and can be different…
PMID: 17712839
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Disruption of the intestinal homeostasis and tolerance towards the resident microbiota is a major mechanism involved in the development …
Molecular phylogeography of endangered sharp-snouted pitviper (Deinagkistrodon …
PMID: 17643319
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 6.3
An alteration in the character and function of platelets is manifested in patients with inflammatory diseases, and these alterations have been disso…
Impact of parental relationships in maximum lod score affected sib-pair method
PMID: 12432507
Year: 2002
Relationship Type:
Mechanism Investigation
Score: 6.3
As a result of extensive clinical and basic research, the pivotal role of tumour necrosis factor (TNF) in the pathogenesis of chronic inflammatory d…
Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated l…
PMID: 10520846
Year: 1999
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Platelet-activating factor (PAF), a potent proinflammatory phospholipid mediator, has been implicated in inducing intestinal inflammatio…
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-med…
PMID: 34876703
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.0
BACKGROUND & AIMS: Although interactions between enteric glial cells (EGCs) and enteric mast cells have been demonstrated to play an important role …
Deciphering the microbiome-metabolome landscape of an inflammatory bowel diseas…
PMID: 40679059
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequen…
Genetically engineered sericin hydrogels for the delivery of human adiponectin …
PMID: 40659150
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Ulcerative colitis (UC) is one type of inflammatory bowel diseases, and adiponectin (APN) is a potential therapeutic protein drug for treating UC. Ho…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||