| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Transcriptional and Epigenetic Regulation of Gasdermins
PMID: 34537234
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Gasdermins (GSDM) are a family of six homologous proteins (GSDMA to E and Pejvakin) in humans. GSDMA-E are pore-forming proteins targeting the plasma…
The Complex Relationship Between Microbiota, Immune Response and Creeping Fat i…
PMID: 34528668
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
In the last decade, there has been growing interest in the pathological involvement of hypertrophic mesenteric fat attached to the serosa of the infl…
The complex relationship between diet, symptoms, and intestinal inflammation in…
PMID: 34435688
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that consists of Crohn's disease (CD) and ulcerati…
Primaquine Diphosphate, a Known Antimalarial Drug, Blocks Vascular Leakage Acti…
PMID: 34149436
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Endothelial barrier integrity is important for vascular homeostasis, and hyperpermeability participates in the progression of many pathological state…
Single- and Multiple-Dose Pharmacokinetics and Pharmacodynamics of PN-943, a Ga…
PMID: 33942566
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 6.3
PN-943 is an orally stable, gastrointestinal-restricted peptide that binds specifically to alpha4ss7 integrin on leukocytes, blocking leukocyte traff…
Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondest…
PMID: 33930606
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND AND AIMS: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA seque…
DSS-induced colitis is associated with adipose tissue dysfunction and disrupted…
PMID: 33674694
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Disruption of the intestinal mucosal barrier integrity is a pathogenic process in inflammatory bowel disease (IBD) development, and is therefore con…
Network Analysis of Common Genes and Transcriptional Factors between Celiac Dis…
PMID: 33564383
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND Understanding the associations among different disorders remarkably improves their diagnosis and treatments. Celiac disease is the most co…
Innate Cells: The Alternative Source of IL-17 in Axial and Peripheral Spondyloa…
PMID: 33488572
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Spondyloarthritis (SpA) is a chronic inflammatory rheumatism characterized by inflammation of sacroiliac joints, peripheral joints, and spine. The As…
Role of Forkhead box O3a transcription factor in autoimmune diseases
PMID: 33412391
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Forkhead box O3a (FOXO3a) transcription factor, the most important member of Forkhead box O family, is closely related to cell proliferation, apoptos…
Comparative Evaluation of Conventional Stool Testing and Multiplex Molecular Pa…
PMID: 33386740
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
AIM: The incidence and clinical manifestations of inflammatory bowel disease (IBD) are thought to have gender differences, which suggests that the e…
Down-regulation of miR-215 attenuates lipopolysaccharide-induced inflammatory i…
PMID: 33146403
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Ulcerative colitis (UC) is a risk factor for carcinogenesis of colorectal cancer, which is associated with disruption of the epithelial barrier and d…
A highly efficient hybrid peptide ameliorates intestinal inflammation and mucos…
PMID: 33058296
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Intestinal inflammatory disorders, such as inflammatory bowel disease, are major contributors to mortality and morbidity in humans and animals worldw…
Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-indu…
PMID: 33021853
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that signal using endogenous acetylcholine (ACh) and the agonist, nicotine.…
CDKN2B-AS1: An Indispensable Long Non-coding RNA in Multiple Diseases
PMID: 32767927
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: In view of the roles of long non-coding RNA CDKN2B antisense RNA 1 (CDKN2BAS1) in various human diseases, we investigated the function of…
IL-37d Negatively Regulates NLRP3 Transcription via Receptor-mediated Pathway a…
PMID: 32582954
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Interleukin-37 (IL-37) is a new negative immune regulator. It has 5 splicing forms, IL-37a-e, and most research mainly focuses on IL-37b …
Anti-colitic effects of Physalin B on dextran sodium sulfate-induced BALB/c mic…
PMID: 32442587
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
ETHNOPHARMACOLOGICAL RELEVANCE: Physalin B is one of the main active withanolide existed in Physalis alkekengi L. var. franchetii (Mast.) Makino, a f…
Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviat…
PMID: 32417423
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
ETHNOPHARMACOLOGICAL RELEVANCE: Huang-lian-Jie-du decoction (HLJDD) is a traditional Chinese medicine prescription for clearing away heat, purging fi…
Inhibition of 5-Lipoxygenase-Derived Leukotrienes and Hemiketals as a Novel Ant…
PMID: 32306507
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
SCOPE: Urolithins (Uro), gut microbial metabolites derived from ellagic acid (EA), reach significant concentrations in the human colon. Uro-A exerts …
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of…
PMID: 32198438
Year: 2020
Relationship Type:
Target Validation
Score: 6.3
Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules that can promote the rapid and selective proteasome-mediated degradat…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||