| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Hongyuyin attenuates intestinal fibrosis in ulcerative colitis in mice revealed…
PMID: 40594739
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease affecting the gastrointestinal tract. Hongyuyin (HYY), a traditional Chinese bo…
[Ecliptasaponin A ameliorates DSS-induced colitis in mice by suppressing M1 mac…
PMID: 40579143
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVES: To investigate the effect of ecliptasaponin A (ESA) for alleviating dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD)…
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon…
PMID: 40571096
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND & AIMS: Total abdominal colectomy (TAC) with a staged ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative co…
Improving the patient care pathway and multidisciplinary management are major c…
PMID: 40530932
Year: 2025
Relationship Type:
Target Validation
Score: 5.8
Hidradenitis suppurativa (HS) is a chronic inflammatory disease resulting from the close interplay between genetic predisposition, dysregulation of t…
Milk-derived exosomes exert anti-inflammatory activity in lipopolysaccharide-in…
PMID: 40502622
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammation is a protective response that occurs when the body is injured and is a primary pathological process that occurs in certain diseases, suc…
Targeting to High-Density Lipoprotein Cholesterol: New Insights for Inflammator…
PMID: 40484317
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: The anti-inflammatory and vasoprotective properties of high-density lipoprotein cholesterol (HDL-C) make it best known in cardiovascular …
Advanced oral drug delivery systems for gastrointestinal targeted delivery: the…
PMID: 40448152
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Oral administration has long been considered the most convenient method of drug delivery, requiring minimal expertise and invasiveness. Unlike inject…
Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in in…
PMID: 40440295
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The destruction of intestinal mucosal mechanical barrier homeostasis caused by excessive apoptosis of intestinal epithelial cells (IECs) is an import…
Investigating the molecular mechanisms associated with ulcerative colitis throu…
PMID: 40433374
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by dysregulated immune responses, resulting in sustained inflammat…
Transcriptomic signatures of host immune responses in aphthous ulcers, the earl…
PMID: 40386941
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Crohn's disease is a chronic, transmural inflammatory disease of the human gut. Changes in the fecal microbial composition and dysbiosis are consiste…
Verapamil inhibits TXNIP-dependent NLRP3 Inflammasome activation in an ulcerati…
PMID: 40359884
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a long-term inflammatory bowel disease (IBD) associated with significant morbidity. It is marked by inflammation and damag…
A Multimodal Therapeutic Strategy for Inflammatory Bowel Disease Using MicroRNA…
PMID: 40324972
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Dysregulated microRNAs (miRNAs) have significant potential as diagnostic tools for various chronic diseases; however, their therapeutic applications …
Integrating transcriptomics, metabolomics, and microbiomics to explore the mech…
PMID: 40324703
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
ETHNOPHARMACOLOGICAL RELEVANCE: Atractylodes lancea (Thunb.) DC. is used in China as a folk medicine for gastrointestinal disorder treatment, and its…
Beta-Sitosterol-Conjugated Sinapic Acid-Engineered Nanoliposome: Biomucoadhesiv…
PMID: 40298241
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Developing oral drug delivery systems is promising for ulcerative colitis (UC). However, the key challenges, including formulation degradation under …
Triple biologic therapy for refractory Crohn's disease
PMID: 40251965
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Despite significant advances in the therapeutic management of Crohn's disease (CD), a subset of patients remains refractory to available …
Role of gut microbiota and mesenteric adipose tissue in the pathology of Crohn'…
PMID: 40248060
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
This editorial comments on the article by Wu et al in the World Journal of Gastroenterology. The article explored the relationship between mesenteric…
Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multipl…
PMID: 40242025
Year: 2025
Relationship Type:
Target Validation
Score: 5.8
BACKGROUND: Clinically, Qing-Re-Hua-Shi Decoction (QRHSD) has been clinically used to treat ulcerative colitis (UC) with satisfactory outcomes and mi…
Akkermansia muciniphila Protects Against Trinitrobenzene Sulfonic Acid Induced …
PMID: 40209092
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Inflammatory bowel disease is a long-standing inflammatory disorder that influences the intestinal tract. The intent of this research is …
Implications of hippocampal excitatory amino acid transporter 2 in modulating a…
PMID: 40203955
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) is characterized by chronic inflammation and significantly impairs quality of life through anxiety-like behaviors an…
Discovery of Potent and Balanced Dual RIPK2 and 3 Inhibitors as a New Strategy …
PMID: 40131099
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) and RIPK3 have been demonstrated to be promising targets for treating multiple inflamm…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||