| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
"Shield" Armed Programmable Probiotics Harboring α-Aminoadipate Aminotransferas…
PMID: 40116595
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered o…
A transcriptional atlas of gut-innervating neurons reveals activation of interf…
PMID: 40101721
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Enteric infections often cause long-term sequelae, including persistent gastrointestinal symptoms, such as pain, discomfort, or irritable bowel syndr…
Adipose-Derived Mesenchymal Stem Cell Exosomes Encapsulating siIL1R2 Facilitate…
PMID: 40035289
Year: 2025
Relationship Type:
Correlation Studies
Score: 5.8
BACKGROUND: Interleukin-1 receptor 2 (IL1R2) and C-C motif chemokine receptor 2 (CCR2) as critical mediators of immune modulation and inflammation. T…
Identification of the key tryptophan metabolic characteristics of Lactiplantiba…
PMID: 40022314
Year: 2025
Relationship Type:
Target Validation
Score: 5.8
Lactiplantibacillus plantarum can activate aryl hydrocarbon receptor (AHR) signaling in the gut by metabolizing tryptophan, thereby counteracting inf…
Innovative Gastrointestinal Drug Delivery Systems: Nanoparticles, Hydrogels, an…
PMID: 40018918
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Over the past decade, new technologies have emerged to increase intrinsic potency, enhance bioavailability, and improve targeted delivery of drugs. M…
Human colon stem cells are the principal epithelial responders to bacterial ant…
PMID: 39975165
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal epithelial cells (IECs) are capable of mounting an adequate antimicrobial inflammatory response to pathogens while tolerating commensals. …
Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon…
PMID: 39974918
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: Total abdominal colectomy (TAC) with a staged ileal pouch-anal anastomosis (IPAA) is a common surgical treatment for ulcerative …
Microbiota-derived IPA alleviates intestinal mucosal inflammation through upreg…
PMID: 39956891
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the …
Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transc…
PMID: 39878512
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
In the gut, microRNAs (miRNAs) produced by intestinal epithelial cells are secreted into the lumen and can shape the composition and function of the …
Akkermansia muciniphila relieves inflammatory response in DSS-induced ulcerativ…
PMID: 39841217
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) remains an intractable and relapsing disease featured by intestinal inflammation. The anti-UC activity of Akkermansia mucinip…
Sometimes Small Is Beautiful: Discovery of the Janus Kinases (JAK) and Signal T…
PMID: 39827247
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The Janus kinase/signal transducer and activator of transfection (JAK/STAT) system is comprised of multiple cell surface receptors, receptor tyrosine…
Specialized pro-resolving lipid mediators in gut immunophysiology: from dietary…
PMID: 39819646
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE OF REVIEW: This review aims to examine recent research on the role of specialized pro-resolving mediators (SPMs) in the regulation of gut imm…
Unusual Phospholipids from Morganella morganii Linked to Depression
PMID: 39818770
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
A multifactorial association study detected a probable causal connection between the prevalence of Morganella morganii in the gut microbiome and the …
Peripheral blood immune cells from individuals with Parkinson's disease or infl…
PMID: 39805368
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Parkinson's Disease (PD) is a multisystem disorder in which dysregulated neuroimmune crosstalk and inflammatory relay via the gut-blood-brain axis ha…
Molecular dynamics simulations to decipher the hotspots at the allosteric site …
PMID: 39799875
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Human 5-lipoxygenase (LOX) is a non-heme, Fe-containing LOX which catalyses the conversion of arachidonic acid (AA) to leukotriene A(4) (LTA(4)). LTA…
Identification of Biomarkers Related to Liquid-Liquid Phase Separation for Ulce…
PMID: 39791167
Year: 2025
Relationship Type:
Target Validation
Score: 5.8
BACKGROUND: Liquid-Liquid Phase Separation (LLPS) is a process involved in the formation of established organelles and various condensates that lack …
Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolo…
PMID: 39554759
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE: Inflammatory bowel disease (IBD) is a serious disease that affects the metabolism and inflammatory responses of human beings. From the persp…
Revolutionizing IBD research with on-chip models of disease modeling and drug s…
PMID: 39523166
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) comprises chronic inflammatory conditions with complex mechanisms and diverse manifestations, posing significant cli…
Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut m…
PMID: 39477928
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
The trillions of microorganisms inhabiting the human gut are intricately linked to human health. While specific microbes have been associated with di…
Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulati…
PMID: 39459904
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) includes patients affected by Crohn's disease or ulcerative colitis. IBD is thought to be a chronic immune-mediated …
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||