| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Genetic insight into the relationship between inflammatory bowel disease and Cl…
PMID: 39436105
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if ge…
Peripheral Blood Immune Cells from Individuals with Parkinson's Disease or Infl…
PMID: 39229100
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Parkinson's Disease (PD) is a multisystem disorder in which dysregulated neuroimmune crosstalk and inflammatory relay via the gut-blood-brain axis ha…
Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent …
PMID: 39212594
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn's Disease (CD) strictures…
Adipose-derived stem cell-based anti-inflammatory paracrine factor regulation f…
PMID: 39173953
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Stem cell-based therapies offer promising avenues for treating inflammatory diseases owing to their immunomodulatory properties. However, challenges …
RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the…
PMID: 39137882
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Group 3 innate lymphoid cells (ILC3s) are abundant in the developing or healthy intestine to critically support tissue homeostasis in response to mic…
Reciprocal regulation of protein arginine deiminase 2 and 4 expression in the c…
PMID: 39070530
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Neutrophils express protein arginine deiminase 2 and PAD4, both of which mediate the citrullination of target proteins to induce production of neutro…
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Color…
PMID: 38981023
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, bo…
Inflammatory proteins may mediate the causal relationship between gut microbiot…
PMID: 38905376
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.8
This research investigates the causal relationships among gut microbiota, inflammatory proteins, and inflammatory bowel disease (IBD), including croh…
Lipocalin-2-mediated intestinal epithelial cells pyroptosis via NF-κB/NLRP3/GSD…
PMID: 38844113
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) characterized by intestinal epithelium damage. Recently, Lipocalin-2 (LCN2) has b…
Stromal-Like Cells Are Found in Peripheral Blood of Patients With Inflammatory …
PMID: 38829958
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.8
INTRODUCTION: Recent studies have identified a critical role of stromal-immune cell interactions in immunity and immune tolerance. Transcriptomic pro…
Safety, tolerability, and pharmacokinetics of single- and multiple-ascending do…
PMID: 38769747
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Olamkicept selectively inhibits the cytokine interleukin-6 (IL-6) trans-signaling pathway without blocking the classic pathway and is a promising imm…
Multiple Mucosal Ulcers Induced by Ixekizumab: A Case Report
PMID: 38742650
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVES: Ixekizumab, an interleukin (IL)-17A inhibitor, exerts its therapeutic effects in psoriasis by inhibiting the interleukin (IL)-17 signalin…
Profiling the patient with inflammatory bowel disease in the relationship betwe…
PMID: 38723769
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
INTRODUCTION: Normal quality of life is an ultimate target in the therapeutic approach to inflammatory bowel diseases (IBD), encompassing Crohn's dis…
Exploration of the potential causative genes for inflammatory bowel disease: Tr…
PMID: 38617957
Year: 2024
Relationship Type:
Target Validation
Score: 5.8
BACKGROUND: Inflammatory bowel disease (IBD) poses a complex challenge due to its intricate underlying mechanisms, and curative treatments remain elu…
Gut Microbiome and Transcriptomic Changes in Cigarette Smoke-Exposed Mice Compa…
PMID: 38612871
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Chronic obstructive pulmonary disease (COPD) patients and smokers have a higher incidence of intestinal disorders. The aim of this study was to gain …
Etanercept-synthesizing adipose-derived stem cell secretome: A promising therap…
PMID: 38577094
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, with tumor necrosis factor (TNF)-alph…
Activation of angiogenin expression in macrophages by lipopolysaccharide via th…
PMID: 38567413
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD manageme…
IBDTransDB: a manually curated transcriptomic database for inflammatory bowel d…
PMID: 38564306
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory Bowel Disease (IBD) therapies are ineffective in at least 40% patients, and transcriptomic datasets have been widely used to reveal the …
Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease …
PMID: 38526083
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
hiPSC-derived intestinal organoids are epithelial structures that self-assemble from differentiated cells into complex 3D structures, representative …
Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by…
PMID: 38474305
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Patients with inflammatory bowel disease (IBD) who experience long-term chronic inflammation of the colon are at an increased risk of developing colo…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||