| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Therapeutic Potential for Sphingolipids in Inflammatory Bowel Disease and Color…
PMID: 38398179
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD), characterized by chronic inflammation in the intestinal tract, increases the risk for the development of colorectal…
Lymphocytic colitis can be transcriptionally divided into channelopathic and in…
PMID: 38366868
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: The pathobiology of the non-destructive inflammatory bowel disease (IBD) lymphocytic colitis (LC) is poorly understood. We aimed to defin…
Investigation of the material basis and mechanism of Lizhong decoction in ameli…
PMID: 38159822
Year: 2024
Relationship Type:
Target Validation
Score: 5.8
ETHNOPHARMACOLOGICAL RELEVANCE: Lizhong decoction (LZD), a classical herbal prescription recorded by Zhang Zhongjing in Treatise on Febrile and Misce…
Marine phospholipid nanoliposomes: A promising therapeutic approach for inflamm…
PMID: 38113752
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Promising findings have been emerged from studies utilizing n3 polyunsaturated fatty acids (PUFA) supplementation in animal models of inflammatory bo…
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative…
PMID: 38110964
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Nanoplastics (NPs) are omnipresent in our lives as a new type of pollution with a tiny size. It can enter organisms from the environment,…
Discovery of a novel GPR35 agonist with high and equipotent species potency for…
PMID: 37976806
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
The G protein-coupled receptor 35 (GPR35) has been identified as a potential target in the treatment of inflammatory bowel disease (IBD). However, th…
Arabinogalactan Alleviates Lipopolysaccharide-Induced Intestinal Epithelial Bar…
PMID: 37895018
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal epithelial barrier (IEB) damage is an important aspect in inflammatory bowel disease (IBD). The objective of this study was to explore the…
Phosphatidylserine-functionalized liposomes-in-microgels for delivering geniste…
PMID: 37877170
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Ulcerative colitis (UC) is an inflammatory disease involving ulcers in the colon and rectum. The conventional treatments for UC still have many limit…
Favipiravir Protects Enterocytes From Cell Death After Inflammatory Storm
PMID: 37873040
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Over the past years, inflammatory bowel disease (IBD) treatment has become more targeted, anticipating the use of immune-modifying therapies at an ea…
Design, Synthesis, anti-inflammatory activity Evaluation, preliminary explorati…
PMID: 37852423
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Most clinical drugs used to treat inflammation have serious gastrointestinal, renal, and cardiovascular side effects during long-term treatment. The …
α-Lipoic acid alleviates dextran sulfate sodium salt-induced ulcerative colitis…
PMID: 37850313
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disease with severe diarrhea, fatigue and weight loss. alpha-Lip…
Scytosiphon lomentaria fucoidan ameliorates DSS-induced colitis in dietary fibe…
PMID: 37820918
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
The prevalence of ulcerative colitis (UC) poses a serious threat to human health. This study showed that fiber-deficient diet (FD) increased the susc…
Anti-Inflammatory Effects of Synthetic Peptides Based on Glucocorticoid-Induced…
PMID: 37759516
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Glucocorticoids (GCs) are commonly used to treat autoimmune and inflammatory diseases, but their clinical effects and long-term use can lead to serio…
Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA
PMID: 37605735
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
PURPOSE: The abnormal activation of NLRP3 inflammasome is related to the occurrence and development of ulcerative colitis (UC). However, the ideal dr…
Cell membrane nanomaterials composed of phospholipids and glycoproteins for dru…
PMID: 37532186
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) is a serious chronic intestinal disorder with an increasing global incidence. However, current treatment strategies,…
P044 A Profile of New Start IBD Patients on Multiple Advanced/Biologic Therapies
PMID: 37461962
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD), consisting of ulcerative colitis (UC) and Crohn's disease (CD), is a chronic relapsing and life-threatening inflam…
LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcr…
PMID: 37454278
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Various extracellular matrix (ECM) reshaping events are involved in inflammatory bowel disease (IBD). LAMB3 is a vital subunit of laminin…
The Involvement of Intestinal Tryptophan Metabolism in Inflammatory Bowel Disea…
PMID: 37447212
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify th…
Mirabegron alleviates acetic acid-induced colitis in rats: Role of adiponectin …
PMID: 37414241
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
The prevalence of the debilitating chronic disease ulcerative colitis (UC) is increasing significantly. Mirabegron is a selective beta-3 adrenergic r…
Topotecan alleviates acetic acid-induced ulcerative colitis in rats via attenua…
PMID: 37414139
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
AIMS: Ulcerative colitis is characterized as a chronic immune-mediated inflammatory condition, affecting the intestinal gastroenteric tissue. Previou…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||