| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Antioxidative effect of Periplaneta americana extract on dextran sulfate sodium…
PMID: 37334466
Year: 2023
Relationship Type:
Target Validation
Score: 5.8
CONTEXT: Periplaneta americana L. (Blattariae) is used as a treatment for ulcerative colitis (UC) in Chinese traditional medicine. OBJECTIVE: To eval…
A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulf…
PMID: 37302524
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Necroptosis, a new form of programmed cell death, is involved in the pathogenesis of ulcerative colitis (UC). Inhibition of necroptosis represents an…
Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatme…
PMID: 37289403
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get activa…
Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Cro…
PMID: 37261910
Year: 2023
Relationship Type:
Target Validation
Score: 5.8
Ulcerative colitis (UC), Crohn's disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with nonsatisfactory therapeutic in…
Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Ag…
PMID: 37239571
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been tho…
IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit i…
PMID: 37214856
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Unchecked chronic inflammation is the underlying cause of many diseases, ranging from inflammatory bowel disease to obesity and neurodegeneration. Gi…
Emerging roles of host and microbial bioactive lipids in inflammatory bowel dis…
PMID: 37191284
Year: 2023
Relationship Type:
Target Validation
Score: 5.8
The intestinal tract harbors diverse microorganisms, host- and microbiota-derived metabolites, and potentially harmful dietary antigens. The epitheli…
Intestinal activating transcription factor 4 regulates stress-related behaviora…
PMID: 37126693
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Chronic stress induces depression- and anxiety-related behaviors, which are common mental disorders accompanied not only by dysfunction of the brain …
Geniposidic acid attenuates DSS-induced colitis through inhibiting inflammation…
PMID: 37098758
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Geniposidic acid (GPA) is a bioactive compound isolated from Gardenia jasminoides Ellis (Rubiaceae) that has long been used to treat arthritis, jaund…
Biosynthetic Enzyme-guided Disease Correlation Connects Gut Microbial Metabolit…
PMID: 36993324
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
The trillions of microorganisms inhabiting the human gut are intricately linked to human health. At the species abundance level, correlational studie…
Differences in Whole-Blood Transcriptional Profiles in Inflammatory Bowel Disea…
PMID: 36982892
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Vedolizumab is efficacious in the treatment of Crohn's disease (CD) and ulcerative colitis (UC). However, a significant proportion of patients presen…
Recent advances in the development of RIPK2 modulators for the treatment of inf…
PMID: 36959850
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Receptor-interacting serine/threonine kinase 2 (RIPK2) is a vital immunomodulator that plays critical roles in nucleotide-binding oligomerization dom…
Cortisone-loaded stearoyl ascorbic acid based nanostructured lipid carriers all…
PMID: 36958119
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Ulcerative colitis is a chronic inflammatory disease which poorly affects the colon and spreads toward the rectum over time. Cortisone (CRT) is a cor…
Treatment of autoimmunity: The impact of disease-modifying therapies in multipl…
PMID: 36924922
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
More than 10 disease-modifying therapies (DMT) are approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for …
TIPE-2 ameliorates inflammatory bowel disease in mice via inhibiting STAT3 and …
PMID: 36848962
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, th…
Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis i…
PMID: 36806346
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
ETHNOPHARMACOLOGICAL RELEVANCE: Piper wallichii (family: Piperaceae), a folk herbal medicine with anti-inflammatory and anti-thrombotic properties, h…
Development of Spleen Targeting H(2)S Donor Loaded Liposome for the Effective S…
PMID: 36744655
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Nanoparticles are primarily taken up by immune cells after systemic administration. Thus, they are considered an ideal drug delivery vehicle for immu…
The role of Akkermansia muciniphila in inflammatory bowel disease: Current know…
PMID: 36685588
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, is a chronic relapsing gastrointestinal inflammatory disease mediated …
Sophorolipids produced by Yarrowia lipolytica grown on Moringa oleifera oil cak…
PMID: 36680771
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVES: Toll-like receptor-4 (TLR-4) activation plays a major role in triggering oxidative stress (OS) and inflammation implicated in the pathoge…
Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classi…
PMID: 36662167
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: There is an unmet medical need for biomarkers that capture host and environmental contributions in inflammatory bowel diseases (IBDs). Th…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||