| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic T…
PMID: 36613488
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Akkermansia muciniphila is a mucosal symbiont considered a gut microbial marker in healthy individuals, as its relative abundance is significantly re…
Differentially Expressed Cell Cycle Genes and STAT1/3-Driven Multiple Cancer En…
PMID: 36497125
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Psoriasis is a persistent T-cell-supported inflammatory cutaneous disorder, which is defined by a significant expansion of basal cells in the epiderm…
[Review of classical prescriptions in treatment of ulcerative colitis]
PMID: 36471997
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis(UC) is a continuous inflammatory bowel disease with the main clinical manifestations of abdominal pain, diarrhea, and mucous blood…
[Mechanism of Shenling Baizhu Powder in alleviation of ulcerative colitis in mi…
PMID: 36471940
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
High-throughput transcriptome sequencing was used to study the mechanism of Shenling Baizhu Powder(SLBZP) in the alleviation of the dextran sulfate s…
Advances in Lipid-Based Codelivery Systems for Cancer and Inflammatory Diseases
PMID: 36453542
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Combination therapy targeting multiple therapeutic targets is a favorable strategy to achieve better therapeutic outcomes in cancer and inflammatory …
A shared tissue transcriptome signature and pathways in psoriasis and ulcerativ…
PMID: 36396672
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Despite multiple efficacious therapies in common between psoriasis (PS) and Ulcerative Colitis (UC), mechanisms underlying their common pathophysiolo…
A novel gut-restricted RIPK1 inhibitor, SZ-15, ameliorates DSS-induced ulcerati…
PMID: 36368417
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
As a key mediator of cell death and inflammation, receptor-interacting protein kinase 1 (RIPK1) responds to a broad set of inflammatory and pro-death…
Pioglitazone Attenuates the Effects of Peripheral Inflammation in a Human In Vi…
PMID: 36361571
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Biological mediators secreted during peripheral chronic inflammation reach the bloodstream and may damage the blood-brain barrier (BBB), triggering c…
Auricularia polytricha and Flammulina velutipes reduce liver injury in DSS-indu…
PMID: 36272692
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Auricularia polytricha and Flammulina velutipes are two dietary mushrooms mostly consumed in China and known for their traditional use on gastric ulc…
G9a Modulates Lipid Metabolism in CD4 T Cells to Regulate Intestinal Inflammati…
PMID: 36272457
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND & AIMS: Although T-cell intrinsic expression of G9a has been associated with murine intestinal inflammation, mechanistic insight into the …
Lipocalin 2 activates the NLRP3 inflammasome via LPS‑induced NF‑κB signaling an…
PMID: 36263611
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Lipocalin 2 (LCN2) is highly expressed in several infectious and inflammatory disorders. However, the expression level and underlying mechanism of LC…
Lactobacillus rhamnosus CY12 Enhances Intestinal Barrier Function by Regulating…
PMID: 36232464
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
The intestinal barrier is vital for preventing inflammatory bowel disease (IBD). The objectives of this study were to assess whether the Lactobacillu…
IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in …
PMID: 36186987
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Cardiac dysfunction is one of the most common complications of sepsis and is associated with the adverse outcomes and high mortality of s…
Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulc…
PMID: 36144733
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Various potential effect of drugs on alleviating diseases by regulating intestinal microbiome as well as the pharmaceutical excipients on…
Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice
PMID: 36142324
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
There are significant sex differences in colorectal cancer (CRC), including in incidence, onset, and molecular characteristics. Further, while inflam…
Relationship of NLRP3 inflammasome with periodontal, endodontic and related sys…
PMID: 36107371
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an inflammasome associated with oral and general health. There is a bidirectional relatio…
The therapeutic effects of cycloastragenol in ulcerative colitis by modulating …
PMID: 36029292
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Patients with ulcerative colitis (UC) experience diarrhoea, hematochezia and abdominal pain. UC is a well-known health challenge affecting 200-250 pe…
Electroacupuncture Reduces Anxiety Associated With Inflammatory Bowel Disease B…
PMID: 35873560
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
The therapeutic effects of electroacupuncture (EA) on the comorbidity of visceral pain and anxiety in patients with inflammatory bowel disease (IBD) …
HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP
PMID: 35872700
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVE: Ulcerative colitis (UC) is closely related to immune response, in which Treg cells (Tregs) suppress the autoimmune response of effector T …
MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Canc…
PMID: 35809803
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND & AIMS: MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but its role in tumorigen…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||