| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by induci…
PMID: 35793125
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
CONTEXT: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of gastrointestinal tract, which can develop into colorectal cancer. Trip…
TLR4 regulates RORγt(+) regulatory T-cell responses and susceptibility to colon…
PMID: 35761415
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as obse…
Adipose-Derived Mesenchymal Stem Cells Reprogram M1 Macrophage Metabolism via P…
PMID: 35757749
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic inflammatory bowel disease worldwide. Infiltration of pro-inflammatory macrophages (M1 macrophages) contributes …
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein…
PMID: 35709396
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.8
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Her…
Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Cro…
PMID: 35707871
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVES: Crohn's disease (CD) mesenteric adipose tissue (MAT) inflammation affects enteritis through the interaction between the mesentery and int…
CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor B…
PMID: 35705732
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Ulcerative colitis (UC) features chronic, non-infectious inflammation of the colon. Insulin-like growth factor binding protein 5 (IGFBP5)…
Transcription factor-driven regulation of ILC1 and ILC3
PMID: 35618586
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic and disease settings, such as inflammatory bowel disease (IBD…
Circular RNA_0001187 participates in the regulation of ulcerative colitis devel…
PMID: 35609334
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Circular RNA (circRNA) had been confirmed to participate in ulcerative colitis (UC) development. Circular RNA_0001187 (Circ_0001187) had been found t…
Adipose tissue-derived mesenchymal stem cells' acellular product extracellular …
PMID: 35522572
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
The breakdown of gastrointestinal tract immune homeostasis leads to Crohn's disease (CD). Mesenchymal stem cells (MSCs) have demonstrated clinical ef…
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhib…
PMID: 35439002
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Targeting sphingosine kinase 1 (SphK1) has become a novel strategy for the treatment of inflammatory bowel disease and cancer via the SphK1/S1P signa…
Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chi…
PMID: 35415304
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
All-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, …
Tripartite motif family proteins in inflammatory bowel disease: Mechanisms and …
PMID: 35373402
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease that poses a heavy burden to the global healthcare syst…
Factors Associated With Social Participation in Persons Living With Inflammator…
PMID: 35368323
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease affecting the gastrointestinal tract. IBD is characterized by courses of rela…
Molecular Manipulations and Intestinal Stem Cell-Derived Organoids in Inflammat…
PMID: 35365825
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
The pathogenesis of inflammatory bowel diseases (IBD) involves genetic predisposition, environmental factors, and a broadly dysregulated intestinal i…
[Effect of Sishen Pills and its split prescriptions on Tfr/Tfh9/Tfh17 cells in …
PMID: 35343158
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
This study aims to investigate the regulatory effect of Sishen Pills(SSP) and its split prescriptions Ershen Pills(EP) and Wuweizi Powder(WP) on T fo…
Somatosensory assessments in patients with inflammatory bowel disease: a cross-…
PMID: 35170531
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Pain affects the majority of patients with inflammatory bowel disease (IBD), where pain experiences may be influenced by multiple patient…
Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inf…
PMID: 35134154
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: Regulation of macrophage polarization is a promising strategy for treating inflammatory bowel disease [IBD]. Tollip is an import…
Transcriptional regulation of chemokine network by biologic monotherapy in ileu…
PMID: 35078095
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Crohn's disease (CD) exacerbation is marked by an intense cellular trafficking. We set out to determine the specific impact of biologic t…
Detailed Transcriptional Landscape of Peripheral Blood Points to Increased Neut…
PMID: 35022690
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: Inflammatory bowel disease [IBD] is a chronic relapsing disorder of the gastrointestinal tract, which generally manifests as Cro…
Trifolium pratense ethanolic extract alters the gut microbiota composition and …
PMID: 34983484
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Trifolium pratense (red clover) ethanolic extract (TPEE) has been used as a popular over-the-counter remedy for the management of menopau…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||