| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Gryllus bimaculatus Extract Protects against Lipopolysaccharide-Derived Inflamm…
PMID: 34680642
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Erratum in Front Bioeng Biotechnol. 2022 Sep 23;10:1038443. Adipose derived mesenchymal stem cells (AD-MSCs) have shown therapeutic potential i…
APE1/Ref-1 - One Target with Multiple Indications: Emerging Aspects and New Dir…
PMID: 34557865
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
In the realm of DNA repair, base excision repair (BER) protein, APE1/Ref-1 (Apurinic/Apyrimidinic Endonuclease 1/Redox Effector - 1, also called APE1…
Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan me…
PMID: 34532729
Year: 2021
Relationship Type:
Target Validation
Score: 5.8
Dietary interventions, including dietary ingredients, nutrients and probiotics, exert anti-inflammatory effects in ulcerative colitis (UC). Our previ…
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Th…
PMID: 34521801
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
Targeting oxidative stress and inflammation by novel dietary compounds of natural origin convincingly appears to be one of the most important therap…
Expression of CD49f defines subsets of human regulatory T cells with divergent …
PMID: 34504692
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing wor…
[Mechanism of Sanhuang Decoction in alleviating dextran sulfate sodium induced …
PMID: 34472268
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
This study explored the mechanism of Sanhuang Decoction(SHD) in treating dextran sulfate sodium(DSS)-induced ulcerative colitis(UC) in mice with Cand…
The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-ind…
PMID: 34462571
Year: 2022
Relationship Type:
Clinical Research
Score: 5.8
Receptor interacting protein kinase 1 (RIPK1) is a cytosolic multidomain protein that controls cell life and death. While RIPK1 promotes cell death t…
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biom…
PMID: 34414506
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND & AIMS: An immune component of inflammatory bowel disease is up-regulated tumor necrosis factor-like ligand 1A (TL1A). Anti-TL1A antibodi…
An NF-κB-responsive long noncoding RNA, PINT, regulates TNF-α gene transcriptio…
PMID: 34405442
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Long noncoding RNAs (lncRNAs) are central regulators of the inflammatory response and play an important role in inflammatory diseases. PINT has been …
Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irrita…
PMID: 34238154
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Lipidomics is an emerging and promising omic that analyzes different lipid molecules in a biological sample. It is considered as a branch of metabolo…
Integrated Transcriptome Profiling Revealed That Elevated Long Non-Coding RNA-A…
PMID: 34220794
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE: Systemic lupus erythematosus (SLE) is a serious autoimmune disease. Its molecular pathogenesis, especially the long non-coding RNA (lncRNA) …
Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical t…
PMID: 34162924
Year: Unknown
Relationship Type:
Target Validation
Score: 5.8
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II d…
Tilapia head glycolipids protect mice against dextran sulfate sodium-induced co…
PMID: 34162163
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a rare cholangiopathy of unknown aetiopathogenesis. The aim of this study was to evaluate…
Potential targets and the action mechanism of food-derived dipeptides on coliti…
PMID: 34037039
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Food-derived peptides can ameliorate colitis but their pharmaceutical targets and action mechanism of ameliorating colitis remain unclear. Here, we a…
Identification of Crucial Genes and Related Transcription Factors in Ulcerative…
PMID: 33941565
Year: 2021
Relationship Type:
Target Validation
Score: 5.8
OBJECTIVE: Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease. To date, the pathogenesis of UC has not been…
Compound Sophorae Decoction: treating ulcerative colitis by affecting multiple …
PMID: 33875167
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic refractory non-specific intestinal inflammatory disease that is difficult to be cured. The discovery of new ulce…
Sustained long-term benefits of patient support program participation in immune…
PMID: 33843252
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Patient support programs (PSPs) improve medication-taking behavior in the first 12 months of treatment for patients with immune-mediated …
CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions
PMID: 33777580
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
CD26/Dipeptidyl peptidase IV (DPPIV) is a cell surface glycoprotein with numerous roles including glucose metabolism, immunomodulation, and tumorigen…
[Progress on relationship between IL-23/IL-17 axis and inflammatory bowel disea…
PMID: 33766235
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
Chronic inflammatory damage of intestinal mucosa is an important characteristic of inflammatory bowel disease (IBD). Studies have shown that the inte…
Tribulus terrestris L. Extract Protects against Lipopolysaccharide-Induced Infl…
PMID: 33628304
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammation response is a regulated cellular process and excessive inflammation has been recognized in numerous diseases, such as cardiovascular dis…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||