| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Integrative transcriptomic and metabonomic profiling analyses reveal the molecu…
PMID: 33535180
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
This study aimed to investigate the therapeutic mechanism of Huankuile suspension (HKL), a typical traditional Chinese medicine, on ulcerative coliti…
Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes…
PMID: 33503442
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE: Uveitis is a heterogeneous collection of diseases. We tested the hypothesis that despite the diversity of uveitides, there could be common m…
Mechanism of endocytic regulation of intestinal tight junction remodeling durin…
PMID: 33484473
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal epithelial cells are tightly bound by tight junction proteins (TJP) which are dynamic and sensitive to environmental stress. However, the …
RAFFI: Accurate and fast familial relationship inference in large scale biobank…
PMID: 33476339
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.8
Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) and choline. ATX has been implicat…
Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight M…
PMID: 33356298
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A …
Differences in amino acid and lipid metabolism distinguish Crohn's from idiopat…
PMID: 33337668
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
INTRODUCTION: Few studies have investigated perianal fistula etiopathogenesis, and although the cryptoglandular theory is widely accepted in idiopath…
4-O-methylascochlorin attenuates inflammatory responses induced by lipopolysacc…
PMID: 33316741
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammation is implicated in various diseases, such as inflammatory bowel disease and cancer. Ascochlorin (ASC) and its derivatives have been shown …
iPSC-derived hepatocytes generated from NASH donors provide a valuable platform…
PMID: 33268331
Year: Unknown
Relationship Type:
Target Validation
Score: 5.8
Non-alcoholic fatty liver disease (NAFLD) affects 30-40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholi…
Statin use and new-onset of inflammatory bowel disease: A systematic review and…
PMID: 33245900
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Erratum in Curr Med Sci. 2020 Dec;40(6):1204. Although the exact etiology of inflammatory bowel disease (IBD) remains unclear, exaggerated immu…
Heat shock transcription factor 2 reduces the secretion of IL-1β by inhibiting …
PMID: 33181254
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is a chronic inflammatory disease with unknown aetiology. As a pro-inflammatory cytokine, interleukin-1beta (IL-1beta) plays …
Knee Joint Swelling at Presentation: A Case of Pediatric Crohn Disease With a T…
PMID: 33177168
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Crohn disease (CD) is a chronic inflammatory disease, and its incidence in children is rising. Despite extensive reports and investigations, the path…
Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut…
PMID: 32722246
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
The management of visceral pain is a major clinical problem in patients affected by gastrointestinal disorders. The poor knowledge about pain chronic…
Network-based characterization of disease-disease relationships in terms of dru…
PMID: 32657408
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
MOTIVATION: Disease states are distinguished from each other in terms of differing clinical phenotypes, but characteristic molecular features are oft…
Role of bioactive sphingolipids in physiology and pathology
PMID: 32579188
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.8
Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases, namely the organic aliphatic amino alcohol sphingosine (Sph), t…
Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal…
PMID: 32538201
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Background: Mucosal healing(MH) is a treatment goal in ulcerative colitis (UC). Our previous studies showed heat shock transcription factor 2 (HSF2) …
A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and mod…
PMID: 32457323
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.8
Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine, involved in Alzheimer's disease pathogenesis. Anti-TNF-alpha therapeutic appr…
Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocyt…
PMID: 32365195
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: The aim of this study was to investigate the metabolic profile of mesenteric adipocytes and the correlations between key metabol…
Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and …
PMID: 32335157
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.8
The anti-inflammatory drug candidate, 6-shogaol, has demonstrated excellent efficacies in various in vitro studies. However, its rapid metabolism aft…
Transcriptional Signatures That Define Ulcerative Colitis in Remission
PMID: 32322884
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of u…
A network pharmacology study on the Tripteryguim wilfordii Hook for treatment o…
PMID: 32293395
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: To explore the mechanism of action of Tripterygium wilfordii Hook (TWH) in the treatment of Crohn's disease (CD) by network pharmacology.…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||