| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The Bcr-Abl inhibitor GNF-7 inhibits necroptosis and ameliorates acute kidney i…
PMID: 32247850
Year: 2020
Relationship Type:
Target Validation
Score: 5.8
Necroptosis is a form of programmed, caspase-independent cell death that is involved in various pathologic disorders such as ischemia/reperfusion inj…
Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through …
PMID: 32239008
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Tea consumption has been found to be associated with low incidence of inflammatory bowel disease in Asian countries. However, there is very limited k…
Tissue alarmins and adaptive cytokine induce dynamic and distinct transcription…
PMID: 32033836
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
The respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNbeta), and IL-21 produced by T cells on the reprogramming of cy…
Lower peripouch fat area is related with increased frequency of pouch prolapse …
PMID: 32020266
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Alterations to epithelial tight junctions can compromise the ability of the epithelium to act as a barrier between luminal contents and …
The relationship between the symptom of fatigue and the functioning of patients…
PMID: 31988670
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
IBD treatment is undergoing a transformation with an expanding repertoire of drugs targeting different aspects of the immune response. Three novel c…
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inf…
PMID: 31961824
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Although Western diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), the correspondin…
Heat-shock transcription factor 2 promotes sodium butyrate-induced autophagy by…
PMID: 31923427
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Butyrate-induced autophagy and anti-inflammatory effects of IECs plays an important role in UC. HSP has been proved to be associated with autophagy. …
Prohibitin 1 interacts with signal transducer and activator of transcription 3 …
PMID: 31899195
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
T-helper 17 (Th17) cells are involved in the occurrence and development of several inflammation-associated diseases. Interleukin (IL)-17, the main cy…
Application and Mechanisms of Triptolide in the Treatment of Inflammatory Disea…
PMID: 31866868
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive effects have been emerging as important sources of drugs for t…
Piperine, a functional food alkaloid, exhibits inhibitory potential against TNB…
PMID: 31835924
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Inflammatory bowel disease is a chronic immunoinflammatory disease of the gastrointestinal tract. Piperine, an alkaloid, has been reporte…
Characterization of Prevalence and Health Consequences of Uniparental Disomy in…
PMID: 31607426
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, can…
Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear …
PMID: 31541232
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
The toxic effects of excess dietary iron within the colonic lumen are well documented, particularly in the context of Inflammatory Bowel Disease (IB…
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
PMID: 31427374
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Receptor-interacting serine threonine kinase 1 (RIPK1) is a widely expressed kinase that is essential for limiting inflammation in both mice and huma…
Prescription-based prevalence of biological therapy in patients with psoriasis,…
PMID: 31327630
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE OF REVIEW: Endoscopic ultrasound (EUS) is routinely utilized for evaluation of disorders of the lower gastrointestinal tract. In this review…
"Good Fences Make Good Neighbors": How does the Human Gut Microchip Unravel Mec…
PMID: 31198078
Year: 2020
Relationship Type:
Target Validation
Score: 5.8
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-…
Integrative Analysis of Transcriptomic and Proteomic Profiling in Inflammatory …
PMID: 31173627
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are intestinal chronic inflammatory conditions characterized by altered epithelial barri…
Adipocytes orchestrate the formation of tertiary lymphoid organs in the creepin…
PMID: 31171476
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.8
The most preferable mode of drugs administration is via the oral route but physiological barriers such as pH, enzymatic degradation etc. limit the a…
USP16-mediated deubiquitination of calcineurin A controls peripheral T cell mai…
PMID: 31135381
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Calcineurin acts as a calcium-activated phosphatase that dephosphorylates various substrates, including members of the nuclear factor of activated T …
Dietary Ziziphus jujuba Fruit Attenuates Colitis-Associated Tumorigenesis: A Pi…
PMID: 31135224
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.8
Dendritic cells (DCs) are pivotal in regulating tolerogenic as well as immunogenic responses against microorganisms by directing both the innate and…
RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Loc…
PMID: 31103627
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Comment in Cell Mol Gastroenterol Hepatol. 2019;7(2):409-410. BACKGROUND & AIMS: Crohn's disease is an inflammatory bowel disease that affects …
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||