| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Common functional alterations identified in blood transcriptome of autoimmune c…
PMID: 31076612
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is caused by a dysregulated immune response against normal components of the intestinal microflora combined with de…
A multiplex liquid chromatography tandem mass spectrometry method for the quant…
PMID: 31047150
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.8
The use of therapeutic monoclonal antibodies (mAbs) is steadily increasing. Previous studies have reported the clinical interest of mAb therapeutic-d…
Transcriptional factor ATF3 protects against colitis by regulating follicular h…
PMID: 30862736
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Disruption of mucosal immunity plays a critical role in the pathogenesis of inflammatory bowel disease, yet its mechanism remains not fully elucidate…
Ulcerative colitis-specific delivery of keratinocyte growth factor by neutrophi…
PMID: 30807805
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Keratinocyte growth factor (KGF) was effective to treat ulcerative colitis. However, its poor stability and unspecific distribution toward inflamed b…
Evaluation of IL-12A, IL-12B, IL-23A and IL-27 mRNA expression level genes in p…
PMID: 30774807
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
AIM: Aim of this study was to compare the gene expression of Interleukin 12 members in two phase of IBD. BACKGROUND: Inflammatory bowel disease (IBD)…
Multidisciplinary approach to prostatitis
PMID: 30655633
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They…
Early injection of human adipose tissue-derived mesenchymal stem cell after inf…
PMID: 30635774
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel diseases (IBDs) are sometimes refractory to current therapy or associated with severe adverse events during immunosuppressive ther…
Inflammatory response and its relation to sphingolipid metabolism proteins: Cha…
PMID: 30635081
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
Lysosome is the organelle responsible for breaking down macromolecules to maintain homeostasis and to fight infection. The disruption of normal lysos…
Crohn's Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host A…
PMID: 30634511
Year: 2019
Relationship Type:
Clinical Research
Score: 5.8
The intestinal mucosa of Crohn's disease (CD) patients is abnormally colonized with adherent-invasive Escherichia coli (AIEC) that are able to adhere…
Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered…
PMID: 30515402
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND AND AIMS: CD6 is a crucial regulator of T cell activation and is implicated in the pathogenesis of multiple autoimmune diseases. ALCAM is…
CTLA-4 regulates T follicular regulatory cell differentiation and participates …
PMID: 30301533
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory diseases (ID) are incurable, progressive diseases. Literature evidence cites increasing incidence of these diseases worldwide. When tre…
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell…
PMID: 30254132
Year: Unknown
Relationship Type:
Target Validation
Score: 5.8
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is…
Opioid receptors in the GI tract: targets for treatment of both diarrhea and co…
PMID: 30189347
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute a…
Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectiv…
PMID: 30171835
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
The gut microbiota plays a fundamental role on the education and function of the host immune system. Immunological dysregulation is the cause of nume…
The intestinal barrier in multiple sclerosis: implications for pathophysiology …
PMID: 29860380
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
Biological barriers are essential for the maintenance of homeostasis in health and disease. Breakdown of the intestinal barrier is an essential aspec…
Sigmoid colon mucosal gene expression supports alterations of neuronal signalin…
PMID: 29565640
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
Peripheral factors likely play a role in at least a subset of irritable bowel syndrome (IBS) patients. Few studies have investigated mucosal gene exp…
Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-ind…
PMID: 29555502
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irrit…
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowe…
PMID: 29540173
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflamma…
Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated ca…
PMID: 29464031
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Colorectal cancer (CRC) is the third diagnosed cancer and the second leading cause of cancer-related deaths in the United States. Colorectal cancer i…
Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD…
PMID: 29273328
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
T helper cell subsets play a critical role in providing protection against offending pathogens by secreting specific cytokines. However, unrestraine…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||