| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Characterization and prevalence of spondyloarthritis and peripheral arthritis a…
PMID: 29026327
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Comment in Pediatr Res. 2020 Apr;87(5):805-806. BACKGROUND: Aberrant immune responses play a key role in the pathogenesis of inflammatory bowel…
Suppression of chronic inflammation with engineered nanomaterials delivering nu…
PMID: 28870118
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
As a prototypical pro-inflammatory transcription factor, constitutive activation of NF-kappaB signaling pathway has been reported in several chronic …
Maintenance of macrophage transcriptional programs and intestinal homeostasis b…
PMID: 28783698
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Epigenetic "readers" that recognize defined posttranslational modifications on histones have become desirable therapeutic targets for cancer and infl…
Lipid Oxidation Products in the Pathogenesis of Inflammation-related Gut Diseas…
PMID: 28625152
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: A defective mucosal barrier function is the principal cause of the uncontrolled onset and progression of a number of human inflammatory g…
Administration of geniposide ameliorates dextran sulfate sodium-induced colitis…
PMID: 28595080
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, not only affects millions of patients worldwide, but also increases the risk of co…
Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting fo…
PMID: 28413980
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple scl…
First insight into structure-activity relationships of selective meprin β inhib…
PMID: 28408220
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.8
The astacin proteases meprin alpha and beta are emerging drug targets for treatment of disorders such as kidney failure, fibrosis or inflammatory bow…
Microbiota regulate intestinal epithelial gene expression by suppressing the tr…
PMID: 28385711
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Microbiota influence diverse aspects of intestinal physiology and disease in part by controlling tissue-specific transcription of host genes. However…
IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NF…
PMID: 28327619
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Regulatory and effector T helper (Th) cells are abundant at mucosal surfaces, especially in the intestine, where they control the critical balance be…
Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing i…
PMID: 28260798
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Geniposide is an iridoid glycosides purified from the fruit of Gardenia jasminoides Ellis, which is known to have antiinflammatory, anti-oxidative an…
MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SH…
PMID: 28246471
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
AIM: To explore the mechanism by which microRNA-155 (miR-155) regulates the pathogenesis of experimental colitis. METHODS: A luciferase assay was per…
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized N…
PMID: 28143741
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.8
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysi…
Multiple processes drive genetic structure of humpback whale (Megaptera novaean…
PMID: 27914203
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Estrogen receptor beta (ERβ) has been shown to play a therapeutic role in inflammatory bowel disease (IBD). However, the mechanism underlying how ER…
The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflamma…
PMID: 27806992
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.8
Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insi…
Estimates of the actual relationship between half-sibs in a pig population
PMID: 27670252
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.8
Integrins are a large family of heterodimeric cell adhesion molecules that are key regulators in multiple biological functions. They orchestrate cel…
A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconsti…
PMID: 27491073
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset of di…
Negative Screening Does Not Rule Out the Risk of Tuberculosis in Patients with …
PMID: 27402916
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.8
Lymphatic failure is a histopathological feature of inflammatory bowel disease (IBD). Recent studies show that interaction between platelets and pod…
IL-10/microRNA-155/SHIP-1 signaling pathway is crucial for commensal bacteria i…
PMID: 27395764
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Interleukin 10 (IL-10) microRNA-155 (miR-155)/Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP-1) signaling pathway plays an important…
Deficiency in Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1: A Nov…
PMID: 27253662
Year: 2017
Relationship Type:
Target Validation
Score: 5.8
OBJECTIVE: Early-onset inflammatory bowel diseases can result from a wide spectrum of rare mendelian disorders. Early molecular diagnosis is crucial …
Systemic delivery of IL-27 by an adeno-associated viral vector inhibits T cell-…
PMID: 27106672
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
IL-27 is a heterodimeric cytokine that is composed of two subunits, i.e., EBV-induced gene 3 and IL-27p28 (also known as IL-30). Although the role of…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||