| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Information Needs and Concerns of Patients with Inflammatory Bowel Disease: Wha…
PMID: 26939069
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Long noncoding RNAs (lncRNAs) were recently found to be key regulators of biological functions and associated with human diseases. Thus …
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox …
PMID: 26928964
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: Guanosine triphosphate cyclohydrolase [GCH1] governs the production of the enzyme cofactor tetrahydrobiopterin [BH4] which is es…
Emergence of liposome as targeted magic bullet for inflammatory disorders: curr…
PMID: 26758815
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory diseases are considered to be highly dreadful ones responsible for higher mortality in the developed countries. This includes cancer, ps…
Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in…
PMID: 26732309
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical…
Adipose-Derived Mesenchymal Stem Cells Ameliorate Ulcerative Colitis Through mi…
PMID: 26237452
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Mesenchymal stem cells (MSCs) were reported to accelerate the curing of ulcerative colitis (UC). Altered expression of microRNAs (miRNAs) has recentl…
Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-α, Are Associated Wit…
PMID: 26130999
Year: 2015
Relationship Type:
Therapeutic Applications
Score: 5.8
Vitamin D, beyond its classical roles in the regulation of calcium and phosphorus homeostasis and bone metabolism, has been implicated in multiple …
Prevalence, significance and predictive value of antiphospholipid antibodies in…
PMID: 26078573
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has phy…
Omega-3 fatty acids, lipid rafts, and T cell signaling
PMID: 26001374
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
n-3 polyunsaturated fatty acids (PUFA) have been shown in many clinical studies to attenuate inflammatory responses. Although inflammatory responses …
Abundant genetic overlap between blood lipids and immune-mediated diseases indi…
PMID: 25853426
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well un…
Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and …
PMID: 25683300
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune homeostasis and cytokine secretion. Multiple loci are associated…
Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ …
PMID: 25648899
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
PURPOSE: Inflammatory conditions like inflammatory bowel diseases (IBD) are characterized by increased immune cell infiltration. The chemokine ligan…
IL-17A alone weakly affects the transcriptome of intestinal epithelial cells bu…
PMID: 25105947
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: In contrast to anti-TNF-alpha antibodies, anti-IL-17A antibodies lacked clinical efficacy in a trial with patients suffering from Crohn's…
Cigarette smoking and gastrointestinal diseases: the causal relationship and un…
PMID: 24859303
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
Cigarette smoking is an important risk factor for gastrointestinal (GI) disorders, including peptic ulcers, inflammatory bowel diseases, such as Croh…
Structure-activity relationship study, target identification, and pharmacologic…
PMID: 24767819
Year: 2014
Relationship Type:
Target Validation
Score: 5.8
Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammato…
Intervention effects of QRZSLXF, a Chinese medicinal herb recipe, on the DOR-β-…
PMID: 24637189
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
ETHNOPHARMACOLOGICAL RELEVANCE: Qingre Zaoshi Liangxue Fang (QRZSLXF) is a Chinese medicinal herb recipe that is commonly prescribed for the treatmen…
The relationship between coping, health competence and patient participation am…
PMID: 24230968
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 5.8
Clinical development of drugs for CNS disorders can be a challenging and risky endeavor. In this article we look at the steps required to move a pre…
Altered colonic mucosal Polyunsaturated Fatty Acid (PUFA) derived lipid mediato…
PMID: 24204637
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.8
OBJECTIVES: Ulcerative colitis (UC) is a relapsing inflammatory disorder of unconfirmed aetiology, variable severity and clinical course, characteris…
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is …
PMID: 24166976
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
IL-17 is a proinflammatory cytokine produced by activated Th17 cells and other immune cells. IL-17-producing Th17 cells are major contributors to chr…
Application of liposomes in drug development--focus on gastroenterological targ…
PMID: 23630417
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.8
Over the past decade, liposomes became a focal point in developing drug delivery systems. New liposomes, with novel lipid molecules or conjugates, an…
Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immu…
PMID: 23574330
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||