| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Microarray analyses of peripheral whole blood cells from ulcerative colitis pat…
PMID: 23403617
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Complementary DNA microarray technology allows the simultaneous analysis of the expression of hundreds to thousands of genes. We applied this techniq…
Review article: Description and management of fatigue in inflammatory bowel dis…
PMID: 23311461
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel diseases (IBDs) are complex multifactorial immunological disorders characterized by dysregulated immune reactivity in the intesti…
Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond
PMID: 23275943
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterati…
Drug delivery by polymeric micelles: an in vitro and in vivo study to deliver l…
PMID: 23219878
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Colitis is the term used for chronic inflammatory bowel diseases at substantially increased risk of developing a form of colorectal cancer (CRC) know…
Defective tumor necrosis factor release from Crohn's disease macrophages in res…
PMID: 22434667
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Recent work provides evidence of a failure of acute inflammation in Crohn's disease (CD), and suggests that the primary defect operates a…
In silico analysis of T-bet activity in peripheral blood mononuclear cells in p…
PMID: 22430437
Year: 2009
Relationship Type:
Therapeutic Applications
Score: 5.8
OBJECTIVE: Lactic acid bacteria (LAB) can improve disturbances of indigenous microflora as well as inflammatory bowel diseases (IBD) such as ulcerat…
Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid
PMID: 22423982
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: The cellular and molecular mechanisms of inflammatory bowel disease are not fully understood; however, data indicate that uncontrolled ch…
1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression …
PMID: 22410118
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.8
OBJECTIVE: Substantial number of women with inflammatory bowel disease (IBD) conceives while on anti-TNF-α therapy. The aim was to assess the safety…
Butyrate enhancement of inteleukin-1β production via activation of oxidative st…
PMID: 22247602
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
In inflammatory bowel diseases, interleukin-1beta production is accelerated. Butyrate, a short chain fatty acid, plays an important role in inflammat…
Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide …
PMID: 21956143
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Intestinal myofibroblasts contribute to immune regulation in adults with inflammatory bowel disease but have not been characterised in ne…
Adipocytokines: The pied pipers
PMID: 21808585
Year: 2010
Relationship Type:
Therapeutic Applications
Score: 5.8
Even though there have been major advances in therapy, atherosclerosis and coronary artery disease retain their lead as one of the major causes of mo…
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inf…
PMID: 21804564
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.8
Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial ce…
Epigenetics: principles and practice
PMID: 21734376
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.8
Epigenetics is defined as heritable changes in gene expression that are, unlike mutations, not attributable to alterations in the sequence of DNA. Th…
Ramiprilate inhibits functional matrix metalloproteinase activity in Crohn's di…
PMID: 21535409
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.8
Increased expression of matrix metalloproteinase (MMP)-2, -3 and -9 has been demonstrated in Crohn's disease fistulas, but it is unknown whether thes…
Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in…
PMID: 21334981
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.8
The impact of anti-TNF therapy on systemic immune responses in patients has not been clearly defined. Here, we examined Th1/Th2/Th17 cytokine express…
Lipid based therapy for ulcerative colitis-modulation of intestinal mucus membr…
PMID: 21152327
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.8
Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recen…
The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription F…
PMID: 21119888
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.8
Sonic hedgehog (Shh) signaling is critically important for embryogenesis and other cellular processes in which GLI transcription factors mediate the …
Increased numbers of immature plasma cells in peripheral blood specifically ove…
PMID: 21087446
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.8
Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)…
Dipeptidyl peptidase expression during experimental colitis in mice
PMID: 20186930
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVE: Inflammatory bowel disease (IBD) is characterized by recurrent and severe gastrointestinal inflammation. Activation of inflammatory cells…
Effects of tumor necrosis factor alpha inhibition with infliximab on lipid leve…
PMID: 19279474
Year: 2009
Relationship Type:
Therapeutic Applications
Score: 5.8
Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several inflammatory conditions. However, it is unclear whether this intera…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||