| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Lipid peroxidation and antioxidant status in kidney and liver of rats treated w…
PMID: 19071188
Year: 2009
Relationship Type:
Therapeutic Applications
Score: 5.8
A variety of targets for therapeutic intervention are based upon advances in understanding of the immunopathogenesis of Crohn's disease. Crohn's dis…
Evaluation of a multiplex flow cytometric immunoassay to detect PR3- and MPO-AN…
PMID: 18499121
Year: 2008
Relationship Type:
Mechanism Investigation
Score: 5.8
Although the precise aetiology of inflammatory bowel disease (IBD) remains unclear, recent discoveries have led to an improved understanding of dise…
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dip…
PMID: 17161345
Year: 2006
Relationship Type:
Mechanism Investigation
Score: 5.8
A diagnosis of intestinal lymphoma is currently made on the basis of clinical and morphologic criteria. This can prove problematic for many reasons …
Relationship between Crohn's disease, infection with Mycobacterium avium subspe…
PMID: 17131479
Year: 2006
Relationship Type:
Mechanism Investigation
Score: 5.8
Most people do not develop inflammatory bowel disease (IBD) in spite of the density of the commensal flora. In the past few years, several areas of …
Engineered osteochondral grafts using biphasic composite solid free-form fabric…
PMID: 15588398
Year: 2004
Relationship Type:
Therapeutic Applications
Score: 5.8
For targeting local and systemic inflammatory processes in inflammatory bowel disease (IBD) therapeutic agents of first choice (e.g. aminosalicylate…
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in infla…
PMID: 38583725
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.5
Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the intestinal mucosa, including ulcerative colitis (UC) and…
Increased expression of yes-associated protein/YAP and transcriptional coactiva…
PMID: 34186485
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.5
BACKGROUND: Intestinal obstruction caused by intestinal fibrosis is a common and serious complication of Crohn's disease (CD). Intestinal fibroblasts…
N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: An abundant…
PMID: 31730793
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.5
N-Acetylaspartylglutamate (NAAG) is the third most prevalent neurotransmitter in the mammalian nervous system, yet its therapeutic potential is only …
Human cord blood-derived platelet lysate enhances the therapeutic activity of a…
PMID: 26353774
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.5
BACKGROUND: Omega-3 PUFAs are known to have anti-inflammatory properties, and different mechanisms are involved. GPR120 is a G-protein coupled recep…
Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Incre…
PMID: 40666845
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel diseases (IBD) affect over 6 million people globally and current treatments achieve only 10-20% rates of durable disease remission…
Post Hoc Analysis of Anxiety and Behavioral Changes in Japanese Patients With I…
PMID: 40666190
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
AIMS: The Japan COVID-19 Survey and the Questionnaire for Inflammatory Bowel Disease (J-DESIRE) identified multiple factors associated with anxiety r…
Eggerthella lenta Produces a Cryptic Pro-inflammatory Lipid
PMID: 40650585
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Eggerthella lenta is both one of the most studied and least understood members of the human gut microbiome. Most of the interest in this Gram-positiv…
Biomarker discovery for non-invasive diagnosis of inflammatory bowel disease us…
PMID: 40621466
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
INTRODUCTION: Colonoscopy remains the gold standard for diagnosing inflammatory bowel disease (IBD) even though it is an invasive and costly procedur…
Identification of neutrophil extracellular trap-related biomarkers in ulcerativ…
PMID: 40620701
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: The incidence of ulcerative colitis (UC) is rapidly increasing worldwide, but existing therapeutics are limited. Neutrophil extracellular…
Causal relationship between inflammatory factors and inflammatory bowel disease…
PMID: 40587702
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
Due to the limitations of traditional observational studies, investigating the association between inflammatory factors and inflammatory bowel diseas…
Highly multiplexed molecular inversion probe panel in Plasmodium falciparum tar…
PMID: 40574802
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: The use of next-generation sequencing technologies (NGS) to study parasite populations and their response and evolution to intervention…
Distinct Retrotransposon Transcriptome in Pediatric Crohn's Disease
PMID: 40568672
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Crohn's disease (CD) is an autoimmune condition with inflammation of the gastrointestinal tract. The etiology of CD is complex w…
Integrated Single-Cell Transcriptome Analysis Reveals Novel Insights into the R…
PMID: 40564117
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Background/Objectives: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic g…
Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in…
PMID: 40549261
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
The intricate relationship between vitamin D and metabolic homeostasis has garnered substantial attention recently. The presence of the vitamin D rec…
How lived experiences of illness trajectories, burdens of treatment, and social…
PMID: 40548558
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The workload service users and caregivers take on, and their capacity to do this work, when they engage with and participate in different…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||