| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Piperine Improves DSS-Induced Colitis in Mice via Inhibition of Inflammation an…
PMID: 40456559
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a global health concern with limited therapeutic options. Previous studies have demonstrated that piperine exhibi…
Adiponectin and gastric fundus: A potential target for gut-brain axis dysfuncti…
PMID: 40452002
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Adiponectin (ADPN) is a pleiotropic hormone produced by adipose tissue involved in the control of body weight, energy expenditure, and feeding behavi…
Oral Lipid Nanoparticles for Improving the Efficiency of Drug Delivery Systems …
PMID: 40430840
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent, recurrent, and relapsing inflammation of the mucosal lay…
YTHDF1 activates FBW7 transcription by regulating m(6)A-dependent FOXO1 to faci…
PMID: 40384634
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The prevalence of inflammatory bowel disease (IBD) has increased recently and lacks curative treatments. The involvement of the N6-methyladenosine (m…
Structure-function relationship of the brown seaweed Undaria pinnatifida lamina…
PMID: 40383584
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis is a chronic inflammatory condition of the intestine characterized by mucosal damage and a compromised epithelial barrier. This st…
Targeting symbionts by apolipoprotein L proteins modulates gut immunity
PMID: 40369072
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
The mammalian gut harbours trillions of commensal bacteria that interact with their hosts through various bioactive molecules(1,2). However, the mutu…
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex …
PMID: 40311595
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Citrinin (CTN) is a mycotoxin that is difficult to eliminate and easy to ingest. Chronic exposure to CTN can lead to inflammatory bowel d…
Vitamin D enhances the therapeutic effect of TNF-α antibodies through lipid met…
PMID: 40285831
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The inhibitory effects of the tumor necrosis factor-alpha (TNF-alpha) antibody infliximab (IFX) on colitis are well established. Since IFX dosing is …
Evidence for a Modulatory Effect of a 12-Week Pomegranate Juice Intervention on…
PMID: 40255128
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
This study aimed at investigating the effects of pomegranate juice (POMJ) consumption on inflammatory biomarkers and gene expression in patients with…
Dietary emulsifier Polysorbate 80-induced lipotoxicity promotes intestinal sene…
PMID: 40253120
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal senescence, often characterized by increased oxidative stress, is linked to gastrointestinal disorders such as inflammatory bowel disease …
Orally-deliverable liposome-microgel complexes dynamically remodel intestinal e…
PMID: 40233710
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Probiotics emerges as a promising option for ulcerative colitis (UC) treatment, but its application remains challenging due to insufficient colon-tar…
Modulation of FOXO3a Nuclear Localization by Linagliptin (BI-1356) reveals a ne…
PMID: 40221059
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Globally, the incidence and prevalence rates of ulcerative colitis (UC) show a rising pattern. The limited efficacy and significant adverse effects a…
Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirecti…
PMID: 40217472
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Plasma lipid homeostasis is pivotal in maintaining intestinal health. Inflammatory bowel disease (IBD), encompassing ulcerative colitis (…
Novel Enteric Microsphere of Beclomethasone Dipropionate With Colon Delivery an…
PMID: 40202075
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The present study aimed to develop a novel colon-targeting microsphere of beclomethasone dipropionate (cMS/BDP) with enhanced pharmacological effect …
Using metabolomics to investigate the relationship between the metabolomic prof…
PMID: 40190827
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
Individuals with inflammatory bowel disease (IBD) are at a higher risk of developing mental disorders, such as anxiety and depression. The imbalance …
Genomic prediction with kinship-based multiple kernel learning produces hypothe…
PMID: 40181452
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Genomic prediction encompasses the techniques used in agricultural technology to predict the genetic merit of individuals towards valuabl…
Development of Akkermansia Muciniphila Membrane-Coated Mesoporous Silica Nanopa…
PMID: 40181608
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
While convenient for patient compliance, the efficacy of oral treatments for inflammatory bowel disease (IBD) is often compromised by the dynamic and…
Relationship of visfatin with obesity and osteoporosis in patients with inflamm…
PMID: 40170859
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is an increasingly prevalent condition in developed countries. Alongside the growing number of patients,…
C1Q(+) TPP1(+) macrophages promote colon cancer progression through SETD8-drive…
PMID: 40165182
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional ina…
Highly multiplex molecular inversion probe panel in Plasmodium falciparum targe…
PMID: 40162260
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: The use of next-generation sequencing technologies (NGS) to study parasite populations and their response and evolution to intervention…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||