| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Inulin Protects Caco-2 Cells Against Lipopolysaccharide-Induced Epithelial Barr…
PMID: 40129999
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, triggers inflammatory responses in intestinal epithelial cells…
Reduction of colitis in mice by chemically programmed supramolecular nanoassemb…
PMID: 40128782
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a relapsing disorder characterized by uncontrolled chronic inflammation of the gastrointestinal tract, posing a s…
Reducing severity of inflammatory bowel disease through colonization of Lactipl…
PMID: 40114208
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have show…
Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment …
PMID: 40112040
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
NLRP3 inflammasome is critical in innate immunity and inflammatory responses. A series of novel sulfonylurea-based NLRP3 inflammasome inhibitors was …
Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspec…
PMID: 40102869
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Classical prescriptions of Chinese medicine represent the crystallized wisdom of millennia of clinical practice, enduring as cornerstones of therapeu…
Preventive effect of quinoa polysaccharides on lipopolysaccharide-induced infla…
PMID: 40068754
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammation significantly influences the development of gastrointestinal (GI) diseases such as inflammatory bowel diseases (IBD)and ulcerative colit…
Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription…
PMID: 40067743
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The transcription factor STAT4 has been implicated in the pathogenesis of autoimmune diseases, including inflammatory bowel disease, multiple scleros…
Reducing diagnostic delays of extraintestinal manifestations in inflammatory bo…
PMID: 40041240
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heter…
Synbiotic yacon juice fermented by Lactiplantibacillus plantarum QS7T attenuate…
PMID: 40035703
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease associated with abnormal immune responses to commensal bacteria. The study investig…
Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- …
PMID: 40034858
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal epithelium regeneration and homeostasis must be tightly regulated. Alteration of epithelial homeostasis is a major contributing factor to …
Genetic determinants of inflammatory cytokines and their causal relationship wi…
PMID: 40025158
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
This study utilized two-sample MR to investigate causality between genetically predicted inflammatory markers and the risk of IDB. This research leve…
Melatonin Modulates ZAP70 and CD40 Transcripts via Histone Modifications in Can…
PMID: 40005847
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Melatonin (MLT), produced by the pineal gland and other tissues, is known for its anti-inflammatory effects, particularly in regulating inflammatory …
Dihydroartemisinin attenuates acetic acid-induced ulcerative colitis in rats: S…
PMID: 39978210
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by the overproduction of reactive oxygen species (ROS) and the rel…
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibr…
PMID: 39970497
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal fibrosis is often observed in inflammatory bowel disease (IBD) and seriously affects intestinal health. Our previous study identified that…
The role of Akkermansia muciniphila in maintaining health: a bibliometric study
PMID: 39967592
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Akkermansia muciniphila, as a probiotic, is negatively linked to IBD, obesity, and T2DM. The aim of this study was to comprehensively ass…
Advances in modeling periodontal host-microbe interactions: insights from organ…
PMID: 39963082
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is driven by an imbalanced interaction between th…
Chemotaxis-driven hybrid liposomes recover intestinal homeostasis for targeted …
PMID: 39961435
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is closely linked to the dysregulation of intestinal homeostasis, accompanied by intestinal epithelial barrier destr…
Inhibitory Effects of Lysophospholipids on Survival and Interleukin-8 Secretion…
PMID: 39956589
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Lysophpsphospholipids (LPLs) are lipid mediators involved in various physiological functions. In daily diets, people consume large amounts of various…
Implications of nociceptor receptors and immune modulation: emerging therapeuti…
PMID: 39955696
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Chronic painful autoimmune disorders such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) induce signific…
Blood transcriptomics identifies FEZ1 as a potential biomarker for inflammatory…
PMID: 39894009
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
INTRODUCTION: While the global burden of inflammatory bowel diseases (IBD) is increasing, the identification of novel therapeutic targets and biomark…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||