| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Lysophosphatidylcholine-induced aberrant adipogenesis in mesenchymal stem cells…
PMID: 39888411
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIM: Creeping fat (CF) in Crohn's disease (CD) is characterized by hyperplastic mesenteric adipose tissue (MAT) encasing fibrotic inte…
Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model o…
PMID: 39866908
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Multiple sclerosis (MS) affects 2.8 million people worldwide. Although the cause is unknown, various risk factors might be involved. MS involves the …
Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), for the Preventi…
PMID: 39862395
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Fecal microbiota, live-jslm (RBL; REBYOTA(R)), is the first single-dose, broad consortia, microbiota-based live biotherapeutic approved b…
Elevated Fecal Lipocalin-2 Levels During Early Life Are Associated with Materna…
PMID: 39856480
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Fecal lipocalin-2 (LCN2) is a biomarker of neutrophil activation, which is elevated in patients with inflammatory bowel disease (IBD); ho…
Pulchinenoside B4 alleviates DSS-induced colitis by inhibiting CD1d-dependent N…
PMID: 39854876
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) represents a significant challenge to global health, underscoring the importance of developing novel alternative anti-colitis…
The combination of Clostridium butyricum and Akkermansia muciniphila mitigates …
PMID: 39840995
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as Clostridium butyricum …
OMIP-110: A 37-Color Spectral Flow Cytometric Panel to Assess Transcription Fac…
PMID: 39838760
Year: 2025
Relationship Type:
Clinical Research
Score: 5.3
We have developed a 37-color spectral flow cytometry panel to assess the phenotypical differentiation of innate and adaptive immune lymphoid subsets …
Immune dysregulation in bipolar disorder
PMID: 39818340
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Bipolar disorder is a debilitating mood disorder associated with a high risk of suicide and characterized by immune dysregulation. In thi…
The Multifaceted Impact of Bioactive Lipids on Gut Health and Disease
PMID: 39769399
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Bioactive lipids have a multifaceted role in health and disease and are recognized to play an important part in gut immunity and disease conditions s…
Outcomes of Hematopoietic Stem Cell Transplantation in 5 Patients with Autosoma…
PMID: 39762600
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Receptor Interacting Serine/Threonine Kinase 1 (RIPK1) is widely expressed and integral to inflammatory and cell death responses. Autosomal recessive…
Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via…
PMID: 39725008
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal ob…
Association of Gut Microbiome and Dipeptidyl Peptidase 4 in Immune-Mediated Inf…
PMID: 39684563
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Immune-mediated inflammatory diseases (IMIDs) are characterized by dysregulated immune responses and chronic tissue inflammation. In the setting of i…
Transcriptional Responses of Lacticaseibacillus rhamnosus to TNFα, IL-6, IL-8, …
PMID: 39596886
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The interaction between gut microbiota and the host immune system is a complex and understudied field, with cytokines like TNFalpha, IL-6, IL-8, and …
Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic E…
PMID: 39591041
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
A novel lipid nanoparticle (nLNP), formulated with three essential lipids to mimic ginger-derived exosomal particles, shows strong potential for deli…
Extracts ofHylotelephiumerythrostictum (miq.) H. Ohba ameliorate intestinal inj…
PMID: 39543569
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The intestinal epithelial barrier is the first line of defense against pathogens and noxious substances entering the body from the outsid…
Leveraging Organ-on-Chip Models to Investigate Host-Microbiota Dynamics and Tar…
PMID: 39491534
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
Inflammatory bowel disease (IBD) is an idiopathic gastrointestinal disease with drastically increasing incidence rates. Due to its multifactorial eti…
Glucocorticoid-Induced Leucine Zipper Protein and Yeast-Extracted Compound Alle…
PMID: 39456254
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel diseases (IBD) have a complex, poorly understood pathogenesis and lack long-lasting effective treatments. Recent research suggests…
Establishment of an ulcerative colitis model using colon organoids derived from…
PMID: 39435148
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The etiology of inflammatory bowel disease (IBD) is complex, with much room for a greater understanding and development of improved therapies. Theref…
Pregnancy zone protein, a potential research target in multiple diseases
PMID: 39433266
Year: 2025
Relationship Type:
Correlation Studies
Score: 5.3
Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the alpha-macroglobulin (alphaM) protein family. PZP is secr…
Cone-Beam Computed Tomography (CBCT)-Based Online Adaptive Radiation Therapy (o…
PMID: 39385924
Year: 2024
Relationship Type:
Target Validation
Score: 5.3
This case report addresses the complex management of a patient with concurrent prostate cancer, inflammatory bowel disease (IBD), and bilateral total…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||