| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
YOD1 sustains NOD2-mediated protective signaling in colitis by stabilizing RIPK2
PMID: 39333628
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a disorder causing chronic inflammation in the gastrointestinal tract, and its pathophysiological mechanisms are …
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerb…
PMID: 39248363
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
Amlexanox (ALX) is a small-molecule drug for the treatment of inflammatory, autoimmune, metabolic, and tumor diseases. At present, there are no studi…
β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 tr…
PMID: 39246845
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Intestinal barrier defect is an essential inflammatory bowel disease (IBD) pathogenesis. Mitochondrial dysfunction results in energy defi…
Navigating the transition: a multidisciplinary approach to inflammatory bowel d…
PMID: 39192007
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
PURPOSE: A multidisciplinary approach to Inflammatory Bowel Disease (IBD) has recently demonstrated a positive impact in pediatric patients, reducing…
Integration of Gut Mycobiota and Oxidative Stress to Decipher the Roles of C-Ty…
PMID: 39115960
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are two subtypes of inflammatory bowel disease (IBD) with rapidly increased incidence wo…
The role of arousal in maintaining the relationship between insomnia and gastro…
PMID: 39091658
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The relationship between gastrointestinal (GI) conditions and sleep disturbance has been well established. With a higher-than-average prevalence of s…
ARE WE READY FOR MULTIPLE SWITCHES BETWEEN REFERENCE PRODUCTS AND BIOSIMILARS?
PMID: 39046007
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel diseases (IBD) currently impose an immense social and economic burden on society in terms of both direct and indirect healthcare c…
Global research trends on the relationship between IBD and CRC: a bibliometric …
PMID: 38867343
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
OBJECTIVE: This study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and …
Target Trial Emulation: Improving the Quality of Observational Studies in Infla…
PMID: 38862178
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The past decade has seen a substantial increase in the number of randomized controlled trials (RCTs) conducted in inflammatory bowel disease (IBD). R…
Synthesis and biological evaluation of chrysin derivatives containing α-lipoic …
PMID: 38860236
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
This study introduces newly discovered chrysin derivatives that show potential as candidate molecules for treating inflammatory bowel disease (IBD). …
MiR-146a alleviates inflammatory bowel disease in mice through systematic regul…
PMID: 38799464
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic disease involving multiple genes, and the current available targeted drugs for IBD only d…
Synthetic Biomimetic Liposomes Harness Efferocytosis Machinery for Highly Effic…
PMID: 38790144
Year: 2024
Relationship Type:
Correlation Studies
Score: 5.3
Macrophages play pivotal roles in the regulation of inflammatory responses and tissue repair, making them a prime target for inflammation alleviation…
Probiotics Armed with In Situ Mineralized Nanocatalysts and Targeted Biocoating…
PMID: 38787330
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
While oral probiotics show promise in treating inflammatory bowel disease, the primary challenge lies in sustaining their activity and retention with…
Research progress in the treatment of inflammatory bowel disease with natural p…
PMID: 38738935
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) comprises a group of highly prevalent and chronic inflammatory intestinal tract diseases caused by multiple factors.…
Remote Between Visit Monitoring in Inflammatory Bowel Disease Care: A Qualitati…
PMID: 38736840
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: We recently showed that CAPTURE-inflammatory bowel disease (IBD)-a care coordination intervention comprised of routine remote monitorin…
Very-early-onset Inflammatory Bowel Disease in an Infant with a Partial RIPK1 D…
PMID: 38676845
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The monogenic causes of very-early-onset inflammatory bowel disease (VEO-IBD) have been defined by genetic studies, which were usually related to pri…
Early Growth Response Protein 1 Exacerbates Murine Inflammatory Bowel Disease b…
PMID: 38672136
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is an inflammatory condition affecting the colon and small intestine, with Crohn's disease and ulcerative colitis be…
"Decoding inflammation: glycoprotein a repetition predominant, microRNA-142-3-p…
PMID: 38598005
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal (GI) condition comprising Crohn's disease (CD) and ulcerative colitis (UC)…
Hippuric acid alleviates dextran sulfate sodium-induced colitis via suppressing…
PMID: 38579536
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with metabolic disorder and gut dysbiosis. Decreased abundance of hippu…
Inflammatory bowel disease activity threatens ankylosing spondylitis: implicati…
PMID: 38482005
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) share common traits of chronic recurrent inflammation affecting both the…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||