| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Inflammatory Bowel Disease: A Nationwide Study of Hip Fracture and Mortality Ri…
PMID: 32170313
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
Conventional systemic and biologic agents are the mainstay of inflammatory bowel disease (IBD) management; however, many of these agents are associa…
Disaster victim identification by kinship analysis: the Lampedusa October 3rd, …
PMID: 31707115
Year: 2020
Relationship Type:
Target Validation
Score: 6.8
Inflammatory bowel disease (IBD) is mostly responsible for the development of colitis-associated colon cancer. Of the several signaling pathways inv…
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activ…
PMID: 31547873
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn's di…
Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-depend…
PMID: 31152156
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds of immunological diseases including colitis. However, there are …
Advanced oxidation protein products induce G1 phase arrest in intestinal epithe…
PMID: 31014575
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
Intestinal epithelial cell (IEC) cycle arrest has recently been found to be involved in the pathogenesis of Crohn's disease (CD). However, the mechan…
Glucocorticoid-Induced Leucine Zipper: A Novel Anti-inflammatory Molecule
PMID: 30971930
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
Glucocorticoids (GCs) are the most commonly used drugs for treatment of autoimmune and inflammatory diseases. Their efficacy is due to their ability …
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Pr…
PMID: 30718226
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiolog…
Prostaglandin E(2) secreted from feline adipose tissue-derived mesenchymal stem…
PMID: 30453939
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.8
Ulcerative colitis (UC) is a prevalent form of inflammatory bowel disease (IBD) whose pathogenic mechanisms remain unclear. Elucidating these mechan…
Effect of the proinflammatory cytokine TNF-α on intestinal riboflavin uptake: i…
PMID: 30156861
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disea…
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, a…
PMID: 30026316
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.8
RIPK1 (receptor-interacting serine/threonine kinase 1) is a master regulator of signaling pathways leading to inflammation and cell death and is of m…
Parathyroid Hormone-Like Hormone Induces Epithelial-to-Mesenchymal Transition o…
PMID: 29577935
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.8
Epithelial-to-mesenchymal transition (EMT) is a key contributor to fibroblast activation in fibrosis of multiple organs, including the intestine. Par…
Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis…
PMID: 27925497
Year: 2017
Relationship Type:
Target Validation
Score: 6.8
CONTEXT AND OBJECTIVE: Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer age…
Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in t…
PMID: 27208127
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.8
Intestinal homeostasis mechanisms must protect the host intestinal tissue from endogenous lipopolysaccharides (LPSs) produced by the intestinal micro…
Th17 Pathway As a Target for Multipotent Stromal Cell Therapy in Dogs: Implicat…
PMID: 26872054
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.8
Detrimental Th17 driven inflammatory and autoimmune disease such as Crohn's disease, graft versus host disease and multiple sclerosis remain a signif…
Idiopathic Non-Cirrhotic Intrahepatic Portal Hypertension (NCIPH)-Newer Insight…
PMID: 25755567
Year: 2014
Relationship Type:
Therapeutic Applications
Score: 6.8
The transient receptor potential vanilloid-4 (TRPV4) belongs to a family of ion channels and can be activated by warm temperature, hypotonicity, cel…
[Effect of qingchang huash recipe on NF-kappaB/Tolls pathway in ulcerative coli…
PMID: 24273977
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 6.8
OBJECTIVE: To observe the effect of Qingchang Huashi Recipe (QHR) on the activation and expressions of nuclear factor kappaB (NF-kappaB), Toll-like r…
Transcriptional modulation of pattern recognition receptors in acute colitis in…
PMID: 23851050
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: In the setting of inflammatory bowel disease, inflammation is associated with a simultaneous increase in angiogenesis; moreover, elevate…
In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper metha…
PMID: 22182430
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 6.8
ETHNOPHARMACOLOGICAL RELEVANCE: Polygonum hydropiper L. (Polygonaceae) has been traditionally used to treat various inflammatory diseases such as rhe…
A functional role for interleukin-21 in promoting the synthesis of the T-cell c…
PMID: 17241869
Year: 2007
Relationship Type:
Mechanism Investigation
Score: 6.8
Inflammatory bowel disease (IBD) affects more than 1 million Americans with more than 30,000 new cases diagnosed each year. IBD increases patient mo…
Clustering patients according to health perceptions: relationships to psychosoc…
PMID: 15046970
Year: 2004
Relationship Type:
Mechanism Investigation
Score: 6.8
Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NF-kappaB, which is involved in the production of cytok…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||