| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The relationship between extreme inter-individual variation in macrophage gene …
PMID: 38421405
Year: 2024
Relationship Type:
Correlation Studies
Score: 5.3
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor recept…
Outcomes in Adult Inflammatory Bowel Disease Clinical Trials: Assessment of Sim…
PMID: 38408273
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIMS: Most paediatric inflammatory bowel disease [IBD] studies are performed after medications are approved in adults, and the majorit…
The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative …
PMID: 38366839
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
AIMS: Patients with mutations in ATP8B1 develop progressive familial intrahepatic cholestasis type 1 [PFIC1], a severe liver disease that requires li…
Transcription factor EB modulates the homeostasis of reactive oxygen species in…
PMID: 38342419
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
Transcription factor EB (TFEB), a master lysosomal biogenesis and autophagy regulator, is crucial for cellular homeostasis, and its abnormality is re…
Activation of mucosal insulin receptor exacerbates intestinal inflammation by p…
PMID: 38243324
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity ar…
Lipid-lowering drugs and inflammatory bowel disease's risk: a drug-target Mende…
PMID: 38191425
Year: 2024
Relationship Type:
Correlation Studies
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with lipid-lowering drugs in observational studies. Drug-target Mendelian randomizat…
Genetic correlation, shared loci, but no causality between bipolar disorder and…
PMID: 38154582
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: The comorbidity between bipolar disorder (BD) and inflammatory bowel disease (IBD) has been widely reported in observational stu…
Hippo pathway in intestinal diseases: focusing on ferroptosis
PMID: 38130953
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past…
Creeping fat exhibits distinct Inflammation-specific adipogenic preadipocytes i…
PMID: 38111581
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Creeping fat (CrF) is an extraintestinal manifestation observed in patients with Crohn's disease (CD). It is characterized by the accumulation of mes…
Colon-Targeted Oral Delivery of Hydroxyethyl Starch-Curcumin Microcapsules Load…
PMID: 38111343
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.3
Combination therapy through colon-targeted oral delivery of multiple drugs presents a promising approach for effectively treating ulcerative colitis …
Cytokine induced inflammatory bowel disease model using organ-on-a-chip technol…
PMID: 38091316
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Over 2 million people in North America suffer from inflammatory bowel disease (IBD), a chronic and idiopathic inflammatory condition. While previous …
The Anti-Inflammatory Effects of Adipose Tissue Mesenchymal Stem Cell Exosomes …
PMID: 38069197
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a group of chronic, relapsing inflammatory disorders that affect the gastrointestinal tract, with the primary sub…
Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the G…
PMID: 38064669
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aim…
Cortical structural changes of morphometric similarity network in early-onset s…
PMID: 38049797
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring the association …
The transcription factor ELF4 alleviates inflammatory bowel disease by activati…
PMID: 38022496
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder affecting millions worldwide. Due to the complexity of its pathoge…
Exploring the oral-gut linkage: Interrelationship between oral and systemic dis…
PMID: 38007003
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.3
The oral cavity harbors a diverse microbiota that plays a significant role in maintaining homeostasis. Disruption of this balance can lead to various…
Inactivation of Group 1B Phospholipase A(2) Enhances Disease Recovery and Reduc…
PMID: 38003345
Year: 2023
Relationship Type:
Correlation Studies
Score: 5.3
Phospholipase A(2) (PLA(2)) enzymes influence inflammatory bowel disease in both positive and negative manners depending on the type of PLA(2) that i…
[The mechanism by which hsa_circRNA_103124 highly expressed in peripheral blood…
PMID: 37981775
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Objective: To investigate the role and related mechanism of the highly expressed circular RNA molecule 103124 (hsa_circRNA_103124) in macrophage diff…
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPH…
PMID: 37976930
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Triphenyl phosphate (TPHP), one widely used organophosphate flame retardant, has attracted accumulating attention due to its high detection rate in h…
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell deve…
PMID: 37965338
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||