| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
A Real-World Prospective Cohort Study of Patients With Newly Diagnosed Crohn's …
PMID: 37941598
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Real-world data on outcomes of patients with newly diagnosed Crohn's disease (ndCD) is limited. We aimed to assess the achievement of cor…
Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism t…
PMID: 37868958
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though the pathogenesis of IBD remains …
Oral delivery of pectin-chitosan hydrogels entrapping macrophage-targeted curcu…
PMID: 37839497
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
The oral delivery of anti-inflammatory drugs has been a promising strategy for enhancing the clinical efficacy of ulcerative colitis (UC) treatment s…
UPLC-QTOF-MS-based lipidomic study of wedelolactone in acute colitis mice induc…
PMID: 37809775
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease is a relapsing inflammatory disease seriously endanger human health. Wedelolactone (WED) is a major active ingredient from…
Prevention of Colitis-Associated Cancer via Oral Administration of M13-Loaded L…
PMID: 37765299
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease, is known to increase the risk of colitis-associated can…
Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ul…
PMID: 37762536
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) is a chronic, incurable condition characterized by mucosal inflammation and intestinal epithelial cell (IEC) dama…
Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel …
PMID: 37736163
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial bar…
Electroacupuncture alleviates ulcerative colitis by targeting CXCL1: evidence f…
PMID: 37727787
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: We aimed to use transcriptomics, bioinformatics analysis, and core gene validation to identify the core gene and potential mechanisms for…
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a P…
PMID: 37726590
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
A severe form of autoimmune-mediated inflammatory bowel disease (IBD) is termed as ulcerative colitis (UC) which ultimately results in significant mu…
Biosensing Intestinal Alkaline Phosphatase by Pregnancy Test Strips Based on Ta…
PMID: 37668549
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
With an increasing incidence worldwide, inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting the gastrointestinal tract, whic…
PER2/P65-driven glycogen synthase 1 transcription in macrophages modulates gut …
PMID: 37660913
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Rectal prolapse in serious inflammatory bowel disease is caused by abnormal reactions of the intestinal mucosal immune system. The circadian clock ha…
Baseline Peripheral Blood Mononuclear Cell Transcriptomics Before Ustekinumab T…
PMID: 37655708
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin (IL)-12 and IL-23, is used for Crohn's disease (CD), and the docum…
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15…
PMID: 37603745
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Glucocorticoids (GC) are potent anti-inflammatory agents, broadly used to treat acute and chronic inflammatory diseases, e.g., critically ill COVID-1…
Mirikizumab-Induced Transcriptome Changes in Ulcerative Colitis Patient Biopsie…
PMID: 37594044
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: Mirikizumab, an anti-interleukin-23p19 monoclonal antibody, demonstrated efficacy in phase 2 and 3 randomized clinical trials of patien…
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the …
PMID: 37580108
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
OBJECTIVES: Interleukin (IL) 17s cytokines are key drivers of inflammation that are functionally dysregulated in several human immune-mediated inflam…
Whipple's Disease; An Overlooked Diagnosis
PMID: 37546505
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Whipple disease is a rare multisystem inflammatory disease. Because fewer than 1000 reported cases have been described, clinical experience with this…
Variation in access and prescription of vedolizumab and ustekinumab in paediatr…
PMID: 37541682
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Therapeutic options for paediatric inflammatory bowel disease (IBD) are limited, especially for younger children. Unlike in adults, vedol…
Efficacy and safety of oral beclomethasone dipropionate and budesonide MMX vers…
PMID: 37538919
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Low bioavailability steroids, including beclomethasone dipropionate (BDP) and budesonide MMX, have been developed to ensure colonic targe…
Smad7 in the hippocampus contributes to memory impairment in aged mice after an…
PMID: 37507781
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common neurological complication following anesthesia and surgery. Increasing evidence ha…
Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of I…
PMID: 37449942
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal metabolism-related diseases, such as constipation, inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer, could be a…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||