| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Enhanced Cytotoxic Activity of 6-Mercaptopurine-Loaded Solid Lipid Nanoparticle…
PMID: 37417972
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
6-Mercaptopurine (6-MCP) is an antiproliferative purine analog used in acute lymphoblastic leukemia, non-Hodgkin lymphoma, and inflammatory bowel dis…
Constitutively active autophagy in macrophages dampens inflammation through met…
PMID: 37392388
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Autophagy is an essential cellular process that is deeply integrated with innate immune signaling; however, studies that examine the impact of autoph…
Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum po…
PMID: 37349311
Year: 2023
Relationship Type:
Correlation Studies
Score: 5.3
Zanzibar has made significant progress toward malaria elimination, but recent stagnation requires novel approaches. We developed a highly multiplexed…
Ulcerative colitis alleviation of colon-specific delivered rhamnolipid/fulleren…
PMID: 37310404
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
As a typical inflammatory bowel disease (IBD), ulcerative colitis (UC) has become prevalent worldwide in recent years. Though several materials have …
Bile salts and proinflammatory cytokines inhibit MCT1-mediated cellular uptake …
PMID: 37290498
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Butyrate (BT) is important in the prevention and inhibition of colorectal cancer (CRC). Inflammatory bowel disease, a risk factor for CRC, is associa…
Akkermansia muciniphila and its membrane protein ameliorates intestinal inflamm…
PMID: 37287024
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia mucinip…
Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflam…
PMID: 37240434
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Several studies in recent years have demonstrated that gut microbiota-host interactions play an important role in human health and disease, including…
Insights into Q-markers and molecular mechanism of Sanguisorba saponins in trea…
PMID: 37207387
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Sanguisorba saponin extract (SSE) is the main active part of Sanguisorba officinalis with various pharmacological activities such as anti…
Follicular Dendritic Cell Sarcoma in a Patient With Adolescent-Onset Crohn's Di…
PMID: 37168632
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Children and adolescents with inflammatory bowel disease are often treated with immunomodulators (thiopurines, methotrexate) and biologics (anti-TNF,…
The single-cell transcriptional landscape of innate and adaptive lymphocytes in…
PMID: 37160121
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells; however, their common and unique transcriptional signatures in p…
Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling…
PMID: 37127609
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse an…
Spermidine protects intestinal mucosal barrier function in mice colitis via the…
PMID: 37104918
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Aryl hydrocarbon receptor (AhR) activation promotes intestinal barrier repair and enhances the gut mucosal barrier function in inflammato…
Early-Life Gut Microbiota Governs Susceptibility to Colitis via Microbial-Deriv…
PMID: 37040489
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to increases in the aerobic bacteria population a…
Functional Analysis of Monkeypox and Interrelationship between Monkeypox and CO…
PMID: 37006463
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The outbreak of monkeypox may be considered a novel and urgent threat after the coronavirus disease (COVID-19). No wide-ranging studies have been con…
Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues
PMID: 36986536
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of H…
Relationship Between Serum Ustekinumab Trough Concentration and Clinical and Bi…
PMID: 36952135
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND AND OBJECTIVES: The role of therapeutic drug monitoring for ustekinumab in the treatment of Crohn's disease has not been defined. This stu…
Collinsella aerofaciens Produces a pH-Responsive Lipid Immunogen
PMID: 36952265
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Some members of the human gut microbiota profoundly influence their host's physiology, health, and therapeutic responses, but the responsible molecul…
Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS-Induced …
PMID: 36920644
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases (IBD) than in the general populatio…
Effects of Medium- and Long-Chain Structured Triacylglycerol on the Therapeutic…
PMID: 36847830
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Due to intestinal malabsorption and poor water solubility, vitamin D (VitD) deficiency in ulcerative colitis (UC) continues to increase. Medium- and …
Protective Effect of Lactiplantibacillus plantarum subsp. plantarum SC-5 on Dex…
PMID: 36832972
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a specific immune-associated intestinal disease. At present, the conventional treatment for patients is not ideal…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||