| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Development of Very-Early-Onset Inflammatory Bowel Disease After Multiple Early…
PMID: 36819429
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
The use of antibiotics has increased drastically over the last few decades. Many antibiotics can target the commensal microbiota and promote gut dysb…
Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal in…
PMID: 36795486
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
As a hallmark of inflammatory bowel disease (IBD), elevated intestinal epithelial cell (IEC) death compromises the gut barrier, activating the inflam…
Integrated multiple microarray studies by robust rank aggregation to identify i…
PMID: 36792688
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
Crohn's disease (CD) is a complex autoimmune disorder presumed to be driven by complex interactions of genetic, immune, microbial and even environmen…
Establishment of a gut-on-a-chip device with controllable oxygen gradients to s…
PMID: 36779280
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and treatment of inflammatory bowel disease (IBD), but the progres…
Disturbance of lipid metabolism in germ-free mice transplanted with gut microbi…
PMID: 36735734
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Hepatobiliary abnormality and metabolic disorders are frequently observed complications in patients with inflammatory bowel diseases (IBD). Given tha…
The landscape of immune dysregulation in Crohn's disease revealed through singl…
PMID: 36720220
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex in…
Geniposide promotes splenic Treg differentiation to alleviate colonic inflammat…
PMID: 36694912
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Geniposide has been proven to have a therapeutic effect on ulcerative colitis (UC) in animals, but its potential mechanism in UC remains to be clarif…
Yiyi Fuzi Baijiang Powder Alleviates Dextran Sulfate Sodium-Induced Ulcerative …
PMID: 36691639
Year: 2023
Relationship Type:
Target Validation
Score: 5.3
Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the intestine, which is prone to recurrence and difficult to cure. Yiyi Fuz…
[Developments in Research on the Relationship Between Porphyromonas gingivalis …
PMID: 36647638
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Porphyromonas gingivalis ( P. gingivalis) is a common periodontal pathogen. Recently, there has been increasing evidence suggesting that P. gingivali…
Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu S…
PMID: 36634382
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS…
Stable colonization of Akkermansia muciniphila educates host intestinal microec…
PMID: 36599931
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Gut microbial preparations are widely used in treating intestinal diseases but show mixed success. In this study, we found that the therapeutic effic…
RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing f…
PMID: 36466854
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
PURPOSE: Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of necroptosis and inflammatory responses. We prese…
Pine Pollen Polysaccharides' and Sulfated Polysaccharides' Effects on UC Mice t…
PMID: 36431783
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The purpose of this study is to explore the effects of pine pollen polysaccharides and sulfated polysaccharides on mice with ulcerative colitis and w…
Study on the preparation of EGCG-γ-Cyclodextrin inclusion complex and its drug-…
PMID: 36423710
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
In this study, gamma-cyclodextrins (gamma-CD) and epigallocatechin-3-gallate (EGCG) were designed to form an inclusion complex (EGCG-gamma-IC) for ul…
Morroniside alleviates lipopolysaccharide-induced inflammatory and oxidative st…
PMID: 36335451
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: To investigate the effects of morroniside on inflammatory and oxidative stress in lipopolysaccharide (LPS)-induced inflammatory bowel dise…
Lipidomics reveals significant alterations associated with exclusive enteral nu…
PMID: 36330386
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Crohn's disease (CD), a type of inflammatory bowel disease, is a chronic idiopathic disorder of the gastrointestinal tract with an increa…
Brexpiprazole prevents colitis-induced depressive-like behavior through myelina…
PMID: 36273507
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Patients with inflammatory bowel disease (IBD) have higher rates of psychiatric pathology including depression. The dextran sulfate sodium (DSS)-trea…
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in i…
PMID: 36270778
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is stil…
Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP/NLRP3 pathway …
PMID: 36251276
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) is a disorder of the bowel that is characterized by a chronic inflammatory response. The traditional Chinese herbal medicine …
Gut-Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Developm…
PMID: 36232813
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Chronic inflammatory bowel disorders (IBD) are idiopathic diseases associated with altered intestinal permeability, which in turn causes an exaggerat…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||