| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The Relationship Between Ferroptosis and Diseases
PMID: 36225859
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Ferroptosis is an iron-dependent mode of cell death. It can occur through two major pathways, exogenous (or transporter-dependent) and endogenous (or…
Human gut microbiota in health and disease: Unveiling the relationship
PMID: 36225386
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The human gut possesses millions of microbes that define a complex microbial community. The gut microbiota has been characterized as a vital organ fo…
Classical prescription Huanglian Decoction relieves ulcerative colitis via main…
PMID: 36209702
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) has affected an increasing number of people globally, with still limited clinical success. Huanglian Decoction (H…
Crohn's disease induced by ocrelizumab in a patient with multiple sclerosis
PMID: 36177822
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Drug-induced inflammatory bowel disease (IBD) is a clinical entity on the rise due to the frequent use of immunomodulatory therapy. Here we report th…
How sphingolipids affect T cells in the resolution of inflammation
PMID: 36176439
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The concept of proper resolution of inflammation rather than counteracting it, gained a lot of attention in the past few years. Re-assembly of tissue…
Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigate…
PMID: 36169577
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Proinflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-alpha) are critical mediators of inflammatory bowel disease pathogenesis, and are …
Novel lipid emulsion for total parenteral nutrition based on 18-carbon n-3 fatt…
PMID: 36166844
Year: 2022
Relationship Type:
Correlation Studies
Score: 5.3
BACKGROUND: While lipid emulsions in modern formulations for total parenteral nutrition (TPN) provide essential fatty acids and dense calories, they …
Considerations when starting patients on multiple biologics and small molecules
PMID: 36165042
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) is complex disease that poses significant economic, and psychological burden on patients. Despite…
Effects of human induced pluripotent stem cell-derived intestinal organoids on …
PMID: 36161099
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
INTRODUCTION: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by repeated remissions and relapses. Immunosuppressive drugs hav…
Increased susceptibility to pneumonia due to tumour necrosis factor inhibition …
PMID: 36159650
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Immunomodulators such as tumour necrosis factor (TNF) inhibitors are used to treat autoimmune conditions by reducing the magnitude of the innate immu…
High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome …
PMID: 36157545
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Obesity is associated with an increased risk of developing Crohn's disease (CD), higher disease activity, and comparatively worse clinica…
Chlorogenic Acid and Quercetin in a Diet with Fermentable Fiber Influence Multi…
PMID: 36145086
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis (UC) patients often avoid foods containing fermentable fibers as some can promote symptoms during active disease. Pectin has been …
Transcriptome Evidence Reveals Mitochondrial Unfolded Protein Response Particip…
PMID: 36137967
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Overexposure to manganese (Mn) can lead to neurodegenerative damage, resulting in manganism with similar syndromes to Parkinson's disease…
Comprehensive analysis of microbiome, metabolome and transcriptome revealed the…
PMID: 36115453
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
This study aimed to investigate the protective effect of Moringa oleifera polysaccharide (MOP) on ulcerative colitis (UC) and explore its mechanism t…
Recent findings in Akkermansia muciniphila-regulated metabolism and its role in…
PMID: 36113229
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The mammalian gastrointestinal tract is colonized with a majority of gut microbes, affecting host metabolism and homeostasis. Gut microbiota plays a …
Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon f…
PMID: 36076306
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic relapsing-remitting inflammatory diseases of the gastrointestinal tract that are typically …
A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse ch…
PMID: 36071055
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaici…
Protective mechanisms of Zanthoxylum bungeanum essential oil on DSS-induced ulc…
PMID: 36069282
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The ameliorative effects on ulcerative colitis (UC) as well as the related mechanisms of the essential oil derived from the edible herb Zanthoxylum b…
Anemoside B4 protects against chronic relapsing colitis in mice by modulating i…
PMID: 36037770
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Anemoside B4 (AB4) is reported to prevent acute colitis when given via intraperitoneal injection by two recent studies. However, whether …
GAS6 From CD200+ Adipose-Derived Stem Cells Mitigates Colonic Inflammation in a…
PMID: 36006655
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND AIMS: Stem cell therapy is a promising cell-based treatment modality for inflammatory bowel diseases [IBD], but its application is lim…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||