| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Multiple Sclerosis: A Primary Care Perspective
PMID: 35977131
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system and the most common cause of nontraumatic neurologic disability in …
[Perimyocarditis as a complication of a multiple drug therapy in the treatment …
PMID: 35970187
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
HISTORY AND CLINICAL FINDINGS: A 19-year-old patient presented as an inpatient with an acute flare-up of ulcerative colitis for about six weeks and s…
Oral delivery of IL-22 mRNA-loaded lipid nanoparticles targeting the injured in…
PMID: 35953326
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Oral mRNA delivery is a promising yet understudied approach for treating inflammatory bowel disease (IBD). Inspired by the colon-targeting ability of…
Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysac…
PMID: 35946046
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The pathophysiology of inflammatory bowel diseases (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene …
Diagnostic and Management Considerations for the IPAA With Crohn's Disease-Like…
PMID: 35867686
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Patients with ulcerative colitis often develop medically refractory colonic inflammation or colorectal neoplasia, and approximately 10% t…
The role of LRRK2 in the periphery: link with Parkinson's disease and inflammat…
PMID: 35781002
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Parkinson's disease (PD) is currently considered a multisystemic disorder rather than a pure brain disease, in line with the multiple hit hypothesis …
Viphyllin™, a standardized extract from black pepper seeds, mitigates intestina…
PMID: 35766031
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel diseases (IBD) are the common health concern in populations across the world. Clinical evidence suggests that IBD, characterized b…
Exploration of the Common Gene Characteristics and Molecular Mechanism of Parki…
PMID: 35741659
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
Parkinson's disease (PD) is the second most common neurodegenerative disorder, and the mechanism of its occurrence is still not fully elucidated. Acc…
Medical and Surgical Implications of Mesenteric Adipose Tissue in Crohn's Disea…
PMID: 35731568
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.3
Mesenteric adipose tissue (MAT) has gained substantial attention as an active player in Crohn's disease (CD), but its clinical significance is poorly…
Label-Free Characterization and Quantification of Mucosal Inflammation in Commo…
PMID: 35699622
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Clinical challenges in inflammatory bowel diseases require microscopic in vivo evaluation of inflammation. Here, label-free imaging holds…
E74 Like ETS Transcription Factor 3 is a Negative Regulator of Pathogenic Lamin…
PMID: 35696273
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Interleukin-17A (IL-17A)-expressing T cells, including T helper 17 (Th17) and T helper 17.1 (Th17.1) cells, play a significant role in inflammatory b…
Overview of Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine a…
PMID: 35677821
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a disorder, which involves the gastrointestinal (GI) tract consisting Crohn's disease (CD) and ulcerative colitis…
Holism of Chinese herbal medicine prescriptions for inflammatory bowel disease:…
PMID: 35665678
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease that causes a heavy burden and lacks effective treatments.…
Could Mucosal TNF Transcript as a Biomarker Candidate Help Optimize Anti-TNF Bi…
PMID: 35663996
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
Anti-tumor necrosis factor (TNF) biological therapy has generally been accepted as a standard therapeutic option in inflammatory bowel disease (IBD) …
Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis …
PMID: 35557948
Year: 2022
Relationship Type:
Correlation Studies
Score: 5.3
Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because…
The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Cro…
PMID: 35554517
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIMS: Crohn's disease [CD] is associated with complex microbe-host interactions, involving changes in microbial communities, and gut b…
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis …
PMID: 35503250
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associat…
α-Bisabolol Mitigates Colon Inflammation by Stimulating Colon PPAR-γ Transcript…
PMID: 35465355
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The incidence and prevalence of inflammatory bowel disease (IBD, Crohn's disease, and ulcerative colitis) are increasing worldwide. The etiology of I…
Lipids in Liver Failure Syndromes: A Focus on Eicosanoids, Specialized Pro-Reso…
PMID: 35432367
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Lipids are organic compounds insoluble in water with a variety of metabolic and non-metabolic functions. They not only represent an efficient energy …
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity i…
PMID: 35344430
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
SignificanceSTAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokine…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||