| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent …
PMID: 35342362
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Improving the long-term prognosis of ulcerative colitis (UC) requires sustained deep mucosal colonic healing with histologic remission, making the st…
Adipose-derived mesenchymal stem cells may reduce intestinal epithelial damage …
PMID: 35315792
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis is a chronic, non-specific inflammatory disease that affects mainly the colonic mucosa and submucosa. The pathogenesis of ulcerati…
Parental autoimmune and autoinflammatory disorders as multiple risk factors for…
PMID: 35304436
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Epidemiological studies have raised concerns about the risk of neurodevelopmental disorders (NDD) in children of patients with autoimmune or inflamma…
Efficacy of Wumei Baijiang prescription on regulatory T cells / helper T cells …
PMID: 35294120
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: To observe the therapeutic effect of Wumei Baijiang prescription empirical prescription of Lu Zhizheng, on experimental ulcerative colitis…
Research Progress on the Relationship Between Inflammation and Colorectal Cancer
PMID: 35261946
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Colorectal cancer is one of the common malignant tumors. Relevant epidemiology and a large number of experimental studies have proved that chronic in…
Utilizing Sphingomyelinase Sensitizing Liposomes in Imaging Intestinal Inflamma…
PMID: 35203622
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, resulting in severe symptoms. At the moment,…
Analysing miRNA-Target Gene Networks in Inflammatory Bowel Disease and Other Co…
PMID: 35205414
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Patients with inflammatory bowel disease (IBD) are known to have perturbations in microRNA (miRNA) levels as well as altered miRNA regulation. Althou…
The Dynamics of Nucleotide Variants in the Progression from Low-Intermediate My…
PMID: 35205782
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Multiple myeloma (MM), or Kahler's disease, is an incurable plasma cell (PC) cancer in the bone marrow (BM). This malignancy is preceded by one or mo…
Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Diseas…
PMID: 35185343
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Studies of the mucosal transcriptomic landscape have given new insight into the pathogenesis of inflammatory bowel disease (IBD). Recentl…
[Effects of astragaloside Ⅳ on inflammatory response and percentage of peripher…
PMID: 35178991
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
This study aimed to investigate the anti-inflammatory effect of astragaloside Ⅳ in mice with ulcerative colitis(UC) and its effect on the percentage …
A β-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects agai…
PMID: 35133390
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is associated with the microbial composition of the gut and its metabolites. Akkermansia muciniphila is a probiotic …
Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens
PMID: 35129341
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
The human immune system detects potentially pathogenic microbes with receptors that respond to microbial metabolites. While the overall immune signal…
IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis b…
PMID: 35119210
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease and colorectal cancer are associated with dysregulation of cytokine networks. However, it is challenging to target cytokin…
Host transcriptome signatures in human faecal-washes predict histological remis…
PMID: 35046090
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: Colonoscopy is the gold standard for evaluation of inflammation in inflammatory bowel diseases (IBDs), yet entails cumbersome preparation…
Evaluation of the relationship between the spleen volume and the disease activi…
PMID: 35029912
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is caused by the activation of an abnormal immune response in the intestinal mucosa; the spleen is involved in the m…
Rational Design of Ratiometric Near-Infrared Aza-BODIPY-Based Fluorescent Probe…
PMID: 35019425
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Precise in vivo tracking of hydrogen peroxide is still challenging due to its dynamic complexity and intrinsic background interference. Herein, we de…
Relationship Between Patient Sex and Serum Tumor Necrosis Factor Antagonist Dru…
PMID: 35004778
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Species of Podocarpus are used traditionally in their native areas for the treatment of fevers, asthma, coughs, cholera, chest pain, arthritis, rheu…
MIMOSA2: a metabolic network-based tool for inferring mechanism-supported relat…
PMID: 34999748
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
MOTIVATION: Recent technological developments have facilitated an expansion of microbiome-metabolome studies, in which samples are assayed using both…
Targeting Mechano-Transcription Process as Therapeutic Intervention in Gastroin…
PMID: 34992543
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Mechano-transcription is a process whereby mechanical stress alters gene expression. The gastrointestinal (GI) tract is composed of a series of hollo…
Metagenomic Analysis of the Pediatric-Onset Multiple Sclerosis Gut Microbiome
PMID: 34937787
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND AND OBJECTIVES: Little is known of the functional potential of the gut microbiome in pediatric-onset multiple sclerosis (MS). We performed…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||