| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Protein Kinase CK2 Maintains Reciprocal Balance Between Th17 and Treg Cells in …
PMID: 34904630
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: T helper 17 and regulatory T cells balance have crucial effects on the development of ulcerative colitis (UC). Currently, how to break th…
TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Coliti…
PMID: 34894222
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer in the United States, and inflammatory bowel disease patients have an increa…
The antiinflammatory and antifibrotic effect of olive phenols and Lactiplantiba…
PMID: 34813981
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
OBJECTIVES: After a chronic intestinal injury, several intestinal cells switch their phenotype to activated myofibroblasts, which in turn release an …
Serum trough levels of infliximab are not associated with peripheral arthralgia…
PMID: 34764142
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Infliximab is an efficacious therapy for inflammatory bowel disease and may play a role in management of some extraintestinal manifestati…
E.coli Nissle increases transcription of flagella assembly and formate hydrogen…
PMID: 34751631
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Escherichia coli Nissle (EcN), a probiotic bacterium, has been employed in treating inflammatory bowel disease, but the nature of its therapeutic eff…
A Comprehensive Analysis of the Colonic Flora Diversity, Short Chain Fatty Acid…
PMID: 34745096
Year: 2021
Relationship Type:
Correlation Studies
Score: 5.3
IF1 is a mitochondrial protein involved in the regulation of ATP synthase activity. The role of IF1 remains to be established in inflammatory bowel …
A competitive ligand-binding assay to detect neutralizing antibodies to a bispe…
PMID: 34743610
Year: 2021
Relationship Type:
Correlation Studies
Score: 5.3
Background: Monitoring appearance of neutralizing antibodies (NAbs) to multidomain large molecule drugs is a challenging task. Materials & methods: H…
Tnfaip6 Secreted by Bone Marrow-Derived Mesenchymal Stem Cells Attenuates TNBS-…
PMID: 34707499
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Infliximab is approved for treatment of various chronic inflammatory diseases including inflammatory bowel disease (IBD). However, high variability …
Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enri…
PMID: 34658866
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
The present study aimed to determine if metformin exerts anti-inflammatory and mucus-protective effects via the gut microbiota. Metformin has extensi…
The Multiple Faces of Integrin-ECM Interactions in Inflammatory Bowel Disease
PMID: 34638778
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
The pathogenesis of inflammatory bowel disease (IBD) might be related to the local inflammatory damage and the dysbacteriosis of intestinal flora. P…
Dipeptidyl peptidase-4 inhibitor-induced autoimmune diseases: Current evidence
PMID: 34630898
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Dipeptidyl peptidase-4 inhibitors (DPP-4i) have an important place in the management of type 2 diabetes. The DPP-4 enzyme is ubiquitously distributed…
Drivers of transcriptional variance in human intestinal epithelial organoids
PMID: 34612061
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the human intestinal epi…
Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute C…
PMID: 34612661
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Akkermansia muciniphila has been proved to play a crucial role in the progression of colitis, but its underlying mechanism remains inconclusive. In t…
The Therapeutic Efficacy of Adipose Tissue-Derived Mesenchymal Stem Cell Condit…
PMID: 34604183
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Infantile-onset inflammatory bowel diseases (IO-IBD) is a heterogeneous subgroup of IBD spectrum characterized by age of onset less than 2 years old…
Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Dis…
PMID: 34565718
Year: 2021
Relationship Type:
Target Validation
Score: 5.3
Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. Though the pat…
Identification of causal metabolites related to multiple autoimmune diseases
PMID: 34523675
Year: 2022
Relationship Type:
Target Validation
Score: 5.3
Observational studies provide evidence that metabolites may be involved in the development of autoimmune diseases (ADs), but whether it is causal is …
Safety of biologic treatments in solid organ transplant recipients: A systemati…
PMID: 34507811
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: The development of biological treatments has transformed the management of a broad spectrum of autoimmune/inflammatory diseases. However,…
Treatment approaches to patients with multiple sclerosis and coexisting autoimm…
PMID: 34457039
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
The past decades have yielded major therapeutic advances in many autoimmune conditions - such as multiple sclerosis (MS) - and thus ushered in a new …
Systematic review with meta-analysis: effect of inflammatory bowel disease ther…
PMID: 34453860
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Comment in Am J Gastroenterol. 2021 Oct 1;116(10):2029-2031. Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aim…
Akkermansia muciniphila Exerts Strain-Specific Effects on DSS-Induced Ulcerativ…
PMID: 34422681
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Akkermansia muciniphila is a commensal bacterium of the gut mucus layer. Although both in vitro and in vivo data have shown that A. muciniphila strai…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||