| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Fecal calprotectin levels used as a noninvasive method for screening for chroni…
PMID: 34406311
Year: 2021
Relationship Type:
Target Validation
Score: 5.3
Janus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its…
Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang deco…
PMID: 34376226
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with an incompletely understood pathogenesis. Lo…
The Microbiome as a Potential Target for Therapeutic Manipulation in Pancreatic…
PMID: 34359684
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and is projected to be the second most common cause of cancer-related death…
Telfairia occidentalis mitigates dextran sodium sulfate-induced ulcerative coli…
PMID: 34331468
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate …
DNA-based detection of Mycobacterium avium subsp. paratuberculosis in domestic …
PMID: 34250373
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel diseases (IBD) are prevalent and debilitating diseases; their clinical remedy is desperately unmet. Mesenchymal stem cells (MSCs)…
QbD-Enabled Systematic Development of Ileo-Colonic Targeted Novel Mucoadhesive …
PMID: 34238189
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Flurbiprofen (FLBP), used in the treatment of ulcerative colitis, has a short biological half-life. Frequent intake of FLBP may lead to s…
Selective brain cooling achieves peripheral organs protection in hemorrhagic sh…
PMID: 34220319
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Background: Although whole-body cooling has been reported to improve the ischemic/reperfusion injury in hemorrhagic shock (HS) resuscitation, it is l…
The novel piperazino-enaminone JOAB-40 reduced colitis severity in mice via inh…
PMID: 34198045
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders with increasing incidence and prevalence worldwide. Here, we investigated thym…
MiR-223 promotes pyroptosis of enteritis cells through activating NF-κB signall…
PMID: 34151668
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: Inflammatory bowel diseases (IBDs) are chronic relapsing remitting diseases which potentially result in hospitalisation, requiring long-t…
Thalidomide Attenuates Colitis and Is Associated with the Suppression of M1 Mac…
PMID: 34085173
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The TNF-alpha inhibitor thalidomide is reported to be effective for indu…
The Impact of Dietary Sphingolipids on Intestinal Microbiota and Gastrointestin…
PMID: 34054805
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
The large surfaces of gastrointestinal (GI) organs are well adapted to their diverse tasks of selective nutritional uptake and defense against the ex…
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein K…
PMID: 34009553
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Intestinal fibrosis is a common complication of Crohn's disease (CD). Adiponectin reportedly exerts anti-inflammatory effects in various …
An Overview of the Efficacy and Safety of Ozanimod for the Treatment of Relapsi…
PMID: 34007159
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Multiple sclerosis (MS) is a complex disease of the central nervous system that can cause permanent disability in young adults. A large armamentarium…
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases
PMID: 33935757
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
The rapid development of metagenomics, metabolomics, and metatranscriptomics provides novel insights into the intestinal microbiota factors linked t…
Multidisciplinary management of perianal Crohn's disease
PMID: 33899777
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
PURPOSE OF REVIEW: Multiple new medications with novel mechanisms of action are now available to treat Crohn's disease (CD). However, they have varyi…
Participation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammatio…
PMID: 33897470
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) patients have different faecal microbiota profiles compared to healthy controls.…
Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases…
PMID: 33872605
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Carboxylesterase 2 (CES2/Ces2) proteins exert established roles in (pro)drug metabolism. Recently, human and murine CES2/Ces2c have been discovered a…
Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated …
PMID: 33862275
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND & AIMS: Proper resolution of inflammation is essential to maintaining homeostasis, which is important as a dysregulated inflammatory respo…
Visfatin Regulates Inflammatory Mediators in Mouse Intestinal Mucosa Through To…
PMID: 33856572
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Visfatin is a multifunctional protein involved in inflammatory immune stress. The aim of current study was to explore the role of visfatin in lipopol…
Adipose-derived mesenchymal stem cell-secreted exosome alleviates dextran sulfa…
PMID: 33728664
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal epithelial barrier damage caused by intestinal epithelial cells (IECs) dysfunction plays a crucial role in the pathogenesis and developme…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||